Activins and inhibins / editor-in-chief, Gerald Litwack.

Format:

Book

Contributor:

Litwack, Gerald.

Series:

Vitamins and hormones ; v. 85.

Vitamins and hormones, 0083-6729 ; v. 85

Language:

English

Subjects (All):

Inhibin.

Activin.

Physical Description:

1 online resource (372 p.)

Place of Publication:

Amsterdam : Elsevier, 2011.

Language Note:

English

Summary:

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologica

Contents:

Front Cover; Vitamins and Hormones: Activins and Inhibins; Copyright; Contents; Contributors; Preface; Chapter 1: Activin Receptor-Like Kinase and the Insulin Gene; I. Introduction; II. TGF-beta Family Receptors: ALK; III. Activin Isoforms A, B, and AB; IV. Nodal; V. Insulin Gene Regulation; VI. Conclusion; Acknowledgments; References; Chapter 2: Crystal Structure of Activin Receptor Type IIB Kinase Domain; I. Introduction; II. Type I Receptor Kinase Domain Structures; III. 3D Structure of ActRIIB; IV. Conclusion; References; Chapter 3: Activin/Nodal Signaling and Pluripotency

I. IntroductionII. Conclusion; References; Chapter 4: Intracrine Signaling Mechanisms of Activin A and TGF-beta; I. Common TGF-beta and Activin A Signaling and Target Genes: Focusing on CTGF/CCN2; II. The Early Response to Cellular Stress: Intracellular Activation of TGF-beta; III. Continuous Low-Level Activation of Activin A/TGF-beta Target Genes; IV. Intracrine Signaling: General Aspects; V. Intracrine Signaling of TGF-beta: The Stimulatory Pathway; VI. Intracrine Signaling of TGF-beta: The Inhibitory Pathway; VII. Intracrine Activin A Signaling; VIII. Conclusion; References

Chapter 5: Negative Regulation of Activin Signal TransductionI. Introduction; II. Extracellular Antagonists; III. Negative Regulation of Activin Receptor Function; IV. Inhibitory Smads; V. Interfering with Smad Function; VI. Negative Regulation of Gene Transcription; VII. Conclusions; Acknowledgments; References; Chapter 6: Antagonism of Activin by Activin Chimeras; I. Introduction; II. The Activin/BMP Receptor System; III. Design of Chimeras; IV. Assessment of Binding and Biological Properties of Chimeras; V. Summary, Conclusions, and Future Directions; Acknowledgments; References

Chapter 7: Activins and Cell MigrationI. Introduction; II. Molecular Mechanism of Activin Signaling Regulated Cell Migration; III. The Role of Activins in the Regulation of Tumor Cell Migration and Metastasis; IV. The Role of Activins in the Modulation of Immune Cell Migration; V. Conclusion and Future Prospective; Acknowledgments; References; Chapter 8: The Synthesis and Secretion of Inhibins; I. Introduction; II. Inhibin Expression and Regulation; III. Expression Profile of Inhibin in Human Tissues; IV. Inhibin Assembly; V. Circulating Inhibin Forms; VI. Concluding Remarks; References

Chapter 9: Multifunctional Roles of Activins in the BrainI. Introduction; II. Expression Pattern of Activin and Activin Receptor in the Brain; III. Activin Receptor and its Regulatory Proteins; IV. Functions of Activins in the CNS; V. Conclusion and Perspectives; Acknowledgments; References; Chapter 10: The Role of Activin/Nodal and Wnt Signaling in Endoderm Formation; I. Introduction; II. TGFbeta Signaling; III. WNT/beta-Catenin Signaling; IV. Applied Biology; V. Conclusions; Acknowledgments; References; Chapter 11: Activin in Glucose Metabolism; I. Introduction

II. Activin Activity in Insulin-Producing and Insulin-Sensitive Tissues

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-283-17130-9

9786613171306

0-12-385962-X

OCLC:

741492891