Advances in genetics. Volume 73 / edited by Theodore Friedmann, Jay C. Dunlap, Stephen F. Goodwin.

Format:

Book

Contributor:

Friedmann, Theodore.

Dunlap, Jay C.

Goodwin, Stephen F.

Series:

Advances in genetics ; v. 73.

Advances in genetics, 0065-2660 ; v. 73

Language:

English

Subjects (All):

Genetics.

Physical Description:

1 online resource (291 p.)

Edition:

1st ed.

Place of Publication:

Amsterdam : Elsevier, 2011.

Language Note:

English

Summary:

Genes interact with the environment, experience, and biology of the brain to shape an animal's behavior. This latest volume in Advances in Genetics, organized according to the most widely used model organisms, describes the latest genetic discoveries in relation to neural circuit development and activity.Explores the latest topics in neural circuits and behavior research in zebrafish, drosophila, C.elegans, and mouse modelsIncludes methods for testing with ethical, legal, and social implicationsCritically analyzes future prospects

Contents:

Front Cover; Advances in Genetics; Copyright Page; Contents; Contributors; Chapter 1: Drosophila Models of Parkinson's Disease; I. Introduction; II. Drosophila as a Model Organism; III. Dominant Traits; IV. Recessive Traits; V. Function of the PINK1/Parkin Pathway; VI. Convergent Therapeutic Approaches; VII. Conclusions; Acknowledgments; References; Chapter 2: Cell Cycle Regulated Gene Expression in Yeasts; I. Introduction; II. Cell Cycle Gene Expression in Yeasts; III. Regulatory Networks; IV. Conservation of Controls; V. Importance of Cell Cycle Regulated Gene Expression

VI. Unimportance of Cell Cycle Regulated Gene ExpressionVII. Related Areas of Interest and Topics for Further Study; References; Chapter 3: RNA Editing by Mammalian ADARs; I. Introduction; II. Structure and Evolution of the CDA Domain; III. The ADAs That Act on RNA Family; IV. Testis-Expressed Nuclear RNA-Binding Protein; V. RNA Binding by ADARs; VI. Secondary Structures of RNA-Editing Substrates; VII. Transcripts Edited by ADARs; VIII. Searches for Mammalian Transcripts Edited by ADARs; IX. Consequences of Inosine in Transcripts; X. Inosine-Containing RNA Regulates Gene Expression in trans

XI. Editing and RNA InterferenceXII. ADAR and Disease; XIII. ADAR2 Protects Against Neuronal Degeneration Following Ischemic Insult; XIV. ADAR2 as a ""Neuronal Gatekeeper""; XV. ADAR and Alternative Splicing; XVI. Coordination of Editing and Alternative Splicing; XVII. Conclusion; Acknowledgments; References; Chapter 4: Cell Entry of Enveloped Viruses; I. Introduction; II. Architecture and Structure of the Viral Fusion Machinery; III. How Viruses Subvert Different Cell Proteins for Entry?; IV. Basic and Translational Research Exploiting Entry Properties of Viruses; V. Conclusions

AcknowledgmentsReferences; Chapter 5: Molecular Signaling: How Do Axons Die?; I. Introduction; II. Axonal Transport and How to Block It; III. The Essentials of Axon Survival; IV. Take It or Leave It: What Axons Do Not Need to Survive; V. Protein Turnover Fast and Slow; VI. Axonal Protein Synthesis; VII. Anterograde Survival Signaling; VIII. Adhesion Molecules; IX. Life After (Cell) Death: The WldS Phenotype; X. Summary: Axonal Transport and Axon Survival Signaling; Acknowledgments; References

Chapter 6: Restless Genomes: Humansas a Model Organismfor UnderstandingHost-RetrotransposableElement DynamicsI. Introduction; II. The Human Elements; III. Expression and Regulation; IV. Genomic Instability; V. Impact on Human Health; VI. Conclusions; Acknowledgments; References; Index; Color Plates

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-283-17113-9

9786613171139

0-12-380861-8

OCLC:

741492884