Advances in clinical chemistry. Volume 57 / edited by Gregory S. Makowski.

Format:

Book

Contributor:

Makowski, Gregory S.

Series:

Advances in Clinical Chemistry

Advances in clinical chemistry, 0065-2423 ; v. 57

Language:

English

Subjects (All):

Clinical chemistry.

Physical Description:

1 online resource (277 p.)

Place of Publication:

London : Academic Press, 2012.

Language Note:

English

Summary:

Volume 57 in the internationally acclaimed Advances in Clinical Chemistry contains chapters submitted from leading experts from academia and clinical laboratory science. Authors are from a diverse field of clinical chemistry disciplines and diagnostics, ranging from basic biochemical exploration to cutting-edge microarray technology. Written by authors representing the diverse field of clinical chemistry and diagnostics, reviews in Advances in Clinical Chemistry cover a range of cutting-eduge research ranging from basic biochemical exploration to microarray technology.

Contents:

Front Cover; Advances in Clinical Chemistry; Copyright; Contents; Contributors; Preface; Chapter 1: Advances in hemoglobinopathy detection and identification; Abbrevations; 2 Introduction; 3 Clinical Picture of Inherited Hemoglobin Disorders; 4 Overview of Techniques; 4.1 Simple and Conventional Techniques; 4.2 Advanced Instrumental Techniques; 5 Application of Mass Spectrometry in Hemoglobin Analysis; 5.1 Overview of Common Mass Spectrometric Methods in Hb Variant Detection and Characterization; 5.2 ESI-MS; 5.3 MALDI-ToF-MS; 5.4 Drawback of MS Methods; 5.4.1 Limited Mass Resolution

5.4.2 Restrictions in Quantitation5.5 Advanced MS Methods; 5.5.1 High-Resolution MS (FT-MS); 5.5.2 Intact Hb Analysis; 5.6 Mass Spectrometry in Newborn Screening of Hemoglobin Variants; 5.7 Identification of Hb Variants; 5.7.1 Peptide Mass Fingerprinting; 5.7.2 Sequence Analysis by Mass Spectrometry; 5.7.2.1 Tandem Mass Spectrometry (MSMS); 5.7.2.2 Post-Source Decay; 5.7.3 Top-Down Sequencing; 5.8 Minor Hemoglobin Analysis; 6 DNA Analysis of Hb Variants and Thalassemias; 6.1 Polymerase Chain Reaction; 6.2 Reverse Hybridization; 6.3 Multiplex Ligation-Dependent Probe Amplification

6.4 Array-based Whole Genome Scanning Technologies6.5 DNA Sequencing and ""Next-Generation Sequencing""; 7 Concluding Remarks; References; Chapter 2: Biomarkers in Hemodialysis Patients; 2 Introduction; 3 Cardiovascular Biomarkers; 3.1 Brain Natriuretic Peptide; 3.2 Cardiac Troponins; 4 Inflammation Biomarkers, Adhesion Molecules; 5 Asymmetric Dimethylarginine; 6 Conclusion; References; Chapter 3: Cytokines and Cytokine-Specific Therapy in Asthma; Abbrevations; 2 Introduction; 3 Cytokines; 3.1 Cytokines and Their Networks in Asthma; 4 Cytokine-Directed Therapy in Asthma; 4.1 Interleukin-2

4.2 Interleukin-4 and Interleukin-134.3 Interleukin-5; 4.4 Interleukin-9; 4.5 Interleukin-12; 5 TNF-α and Its Role in Severe Asthma; 5.1 Human Studies of Anti-TNF-α Therapy; 6 Interferons; 7 Other Potential Cytokine Targets in Early Development; 7.1 Interleukin-17; 7.2 Interleukin-18; 7.3 Interleukin-33; 7.4 Thymic Stromal Lymphopoietin/OX40; 7.5 Chemokines; 8 Conclusions; Acknowledgments; References; Chapter 4: Somatic Mitochondrial DNA Mutations in Human Cancers; 2 Introduction; 3 Somatic mtDNA Mutations in Human Cancers; 3.1 Point Mutations; 3.2 Deletions; 3.3 Insertions

3.4 Quantitative mtDNA Alterations4 Potential Implications of Somatic mtDNA Mutations in Cancer Development and Progression; 4.1 Clinicopathological Correlation of Somatic mtDNA Mutations with Cancers; 4.1.1 Point Mutations; 4.1.2 MtDNA Content Turnovers; 4.2 Roles of mtDNA Mutations in Conferring Oncogenic and Metastatic Properties; 5 Mitochondrial and Nuclear Intergenomic Cross talk During Cancer Progression; 6 Potential Diagnostic Application of mtDNA Alterations and Therapeutic Strategies for Targeting mtDNA in Cancer...; 6.1 MtDNA Alterations as Novel Cancer Biomarkers

6.2 Therapeutic Strategies for Targeting mtDNA or Modification of mtDNA Mutations in Cancer

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-280-58233-2

9786613612113

0-12-394418-X

OCLC:

796932711