Advances in clinical chemistry. Volume 55 / edited by Gregory S. Makowski.

Format:

Book

Contributor:

Makowski, Gregory S.

Series:

Advances in Clinical Chemistry

Advances in clinical chemistry, 0065-2423 ; v. 55

Language:

English

Subjects (All):

Clinical chemistry.

Physical Description:

1 online resource (174 p.)

Place of Publication:

London : Academic Press, an imprint of Elsevier, 2011.

Language Note:

English

Summary:

Volume 55 in the internationally acclaimed Advances in Clinical Chemistry contains chapters submitted from leading experts from academia and clinical laboratory science. Authors are from a diverse field of clinical chemistry disciplines and diagnostics, ranging from basic biochemical exploration to cutting-edge microarray technology. Leading experts from academia and clinical laboratory science Volume emphasizes novel laboratory advances with application to clinical laboratory diagnostics and practical basic science studies

Contents:

Front Cover; Advances inClinicalChemistry; Copyright; Contents; Contributors; Preface; HE4 in ovarian cancer: From Discovery to clinical application; 2. Introduction; 3. CA125; 4. Biomarker Identification: From Genomics to Proteomics; 4.1. Genomics and Functional Genomics; 4.2. Proteomics; 5. Clinical Validation of a Tumor Biomarker; 6. HE4: Discovery to Clinical Application; 7. Conclusions; References; Salivary transcriptome biomarkers in oral squamous cell cancer detection; 2. Introduction; 2.1. Aim of this Review; 2.2. Saliva as a Diagnostic Medium

3. The Salivary Transcriptome: Characterization and Biomarker Discovery3.1. The Discovery of a Salivary Transcriptome; 3.2. Exploring the Salivary Transcriptome; 3.3. RNA Stability in Saliva; 3.4. OSCC Biomarkers; 4. Etiopathology of OSCC: The Field Cancerization Theory; 5. Molecular Alterations in OSCC; 5.1. OSCC Tissue-Specific Markers; 5.2. Cancer Cell Biomarkers Do Not Always Equal Salivary Biomarkers; 6. Biomarkers: Adequate Study Design (PRoBE Design); 7. Outlook, Conclusion, and the Oral Fluid Nanosensor Test; 7.1. Salivary Biomarkers for Different Diseases

7.2. The Translation of Salivary Biomarkers into Clinical Reality: The OFNASET7.3. Conclusion and Outlook; References; Laminin isoform profiles in salivary glands in Sjögren's syndrome; 2. Sjögren's Syndrome; 3. Structure of the Human Labial Salivary Glands; 4. Basement Membrane; 5. Laminins; 6. LM Receptors; 7. Regulation of LMs in Salivary Glands; 8. Conclusion; Acknowledgments; References; Adipokine actions on cartilage homeostasis; 2. Introduction; 3. Relevance of Adipokines in Cartilage Disease; 3.1. Leptin; 3.2. Adiponectin; 3.3. Resistin; 3.4. Visfatin; 3.5. Apelin

4. Measurement of Adipokines4.1. Leptin; 4.2. Adiponectin; 5. Adipokines and Cartilage Homeostasis: Integrated View and Perspectives; References; Chemical biology of homocysteine thiolactone and related metabolites; 2. Introduction; 3. Homocysteine Thiolactone; 3.1. Chemical Synthesis; 3.2. Physicochemical Properties; 3.3. Assays in Biological Fluids; 3.4. Biological Formation and Metabolism; 3.5. Clinical Significance; 4. N-Homocysteinylated Proteins; 4.1. Synthesis In Vitro; 4.2. Functional Consequences; 4.3. Assays in Tissue and Plasma; 4.4. Biological Formation and Metabolism

4.5. Biological Consequences and Clinical Significance5. N-Homocysteinyl-lysine; 5.1. Chemical Synthesis; 5.2. Physicochemical Properties; 5.3. Biological Formation; 5.4. Assay in Plasma; 5.5. Clinical Significance; 6. Conclusions; References; Iron overload in nonalcoholic steatohepatitis; 2. Introduction; 3. Incidence of Iron Overload in NAFLD/NASH; 4. Search for the Mechanism of Iron Overload in NAFLD/NASH; 4.1. Liver as a Key Regulatory Organ for Body Iron Homeostasis; 4.2. Possible Molecular Mechanisms of Iron Overload in NAFLD/NASH; 5. Clinical Impact of Iron Overload in NAFLD/NASH

5.1. Involvement of Iron Overload for Liver Disease Progression in NAFLD/NASH

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-283-27601-1

9786613276018

0-12-387043-7

OCLC:

775872099