Heart development / edited by Benoit G. Bruneau.

Format:

Book

Contributor:

Bruneau, Benoit G.

Series:

Current topics in developmental biology ; v. 100.

Current topics in developmental biology, 0070-2153 ; v. 100

Language:

English

Subjects (All):

Heart--Growth.

Heart.

Heart--Growth--Molecular aspects.

Physical Description:

1 online resource (425 p.)

Edition:

1st ed.

Place of Publication:

San Diego, Calif. : Academic Press, 2012.

Language Note:

English

Summary:

The developing heart is the first functional organ, and its proper formation and function is essential for life. This volume compiles the exciting new advances that have been made in understanding the regulation of heart development, the genes and pathways involved, and the impact these have in heart disease. A stellar collection of scientists tackles an important facet of heart development, providing a comprehensive set of reviews. Cutting-edge science Authority of contributors Exciting field of research

Contents:

Front Cover; Heart Development; Copyright; Contents; Contributors; Preface; Chapter 1: Life Before Nkx2.5: Cardiovascular Progenitor Cells: Embryonic Origins and Development; 1 Introduction; 2 Early Heart Development: Is It as Simple as Location, Location, Location?; 3 CPCs: The Building Blocks of the Heart; 4 CPC Determination: The Quest for ""Cardiod""; 5 Signaling Pathways and CPC Fate; 6 A Moving Story: Early CPC Migration and Fate; 7 Changing the Program: CPC Relationship to Reprogramming and Transdifferentiation; 8 Conclusions: Future Questions and Possible Applications; Acknowledgments

ReferencesChapter 2: The Second Heart Field; 1 Introduction; 2 The Discovery of the Second Heart Field; 3 Refinement of the Second Heart Field Model; 4 Regulation of Second Heart Field Deployment; 4.1 Intercellular signaling pathways regulating second heart field development; 4.2 Transcriptional control of second heart field development: Toward a second heart field gene regulatory network...; 5 Clinically Relevant Subdomains of the Second Heart Field; 5.1 Future subpulmonary myocardium and conotruncal congenital heart defects; 5.2 The posterior SHF and atrial septal progenitor cells

6 The Second Heart Field in Vertebrate Evolution7 The Second Heart Field as Part of a Cardiocraniofacial Developmental Field; 8 Perspectives; Acknowledgments; References; Chapter 3: An Unauthorized Biography of the Second Heart Field and a Pioneer/Scaffold Model for Cardiac Development; 1 Introduction; 2 Subpharyngeal Cardiac Precursors; 2.1 Using soft words and hard arguments; 2.1.1 Strong; 2.1.2 Light; 3 Models of Cardiac Development; 3.1 Mosaic, regulative or a patterned mosaic?; 3.2 Retrospective fate mapping highlights the intrinsic unity of the cardiac progenitor population

4 A Historical Account of the SHF Concept4.1 Is the SHF a novel cardiac progenitor domain?; 4.2 Is the SHF a cardiac progenitor region defined on the basis of specific gene expression?; 4.3 Is the SHF a progenitor population defined by expression of specific markers?; 5 Evolution of Isl Expression in Cardiac Development; 5.1 Origins of Isl-1-expression in cardiac progenitors: Rewinding, not rewriting, the tape of cardiac evolution...; 5.2 A comparative analysis of Isl expression in vertebrate chambered heart development; 5.2.1 Mice; 5.2.2 Chicken; 5.2.3 Frogs; 5.2.4 Zebrafish; 5.2.5 Lampreys

5.3 A comparative analysis of Isl expression during the ontogenesis of invertebrate circulatory pumps5.3.1 Ascidian tunicates; 5.3.2 The cephalochordate amphioxus; 5.3.3 Drosophila; 5.4 Origins of Isl-1-expression in cardiac progenitors: A synthesis; 6 Subpharyngeal Cardiac Precursors and Segmental Models of Myocardial Cell Regionalization; 6.1 The axial organization of cardiac segments versus subpharyngeal cardiac precursors: Are these contradictory?...; 6.2 The AP organization of cardiac segments is questioned; 6.3 Do cardiac fate maps reveal an AP organization of cardiac segments?

6.4 Are there any roles for cardiac AP segmentation in heart development?

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9786613612687

9781280582905

1280582901

9780123877901

0123877903

OCLC:

793510896