Advances in protein chemistry and structural biology / edited by Rossen Donev.

Format:

Book

Contributor:

Donev, Rossen.

Series:

Advances in protein chemistry and structural biology ; v. 84.

Advances in protein chemistry and structural biology, 1876-1623 ; v. 84

Language:

English

Subjects (All):

Proteins.

Physical Description:

1 online resource (215 p.)

Edition:

1st ed.

Place of Publication:

Oxford : Academic Press, 2011.

Language Note:

English

Summary:

Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology serial has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics. This volume features articles on Protein Aggregation. <b

Contents:

Front Cover; Advances in Protein Chemistry and Structural Biology; Copyright; Contents; Nucleic acid-mediated protein aggregation and assembly; I. Introduction; II. Nucleic Acid-Mediated Aggregation of Amyloid Proteins; III. Nucleic Acid Sequestration to Pathological Tissues; IV. Self-Assembly of Protein Nanostructures in the Presence of Nucleic Acids; V. Summary; Acknowledgments; References; Aggregation, stability, and formulation of human antibody therapeutics; I. Introduction; II. Expression of Human Monoclonal Antibodies and Antibody Fragments

III. Methods for Analyzing Solubility, Aggregation and Stability of Monoclonal AntibodiesIV. Addressing Aggregation and Increasing Stability of Monoclonal Antibodies; References; Lysozyme; I. Introduction; II. Amyloid and Amyloidosis; III. Human Lysozyme; IV. Aggregation of Hen Lysozyme In Vitro; V. Recovery and Purification of Lysozyme from Inclusion Bodies; VI. Inhibition of Lysozyme Aggregation; VII. Future Perspectives; References; Protein aggregation in a membrane environment; I. Introduction; II. The Role of Electrostatics in Membrane-Mediated Protein Aggregation

III. Hydrophobic Effect as Driving Force for Protein AggregationIV. Hydrogen-Bonding as Determinant of Protein Aggregation Propensity; V. Experimental Techniques Used to Study Protein Aggregation; VI. Concluding Remarks; Acknowledgments; References; Contactins...; I. Introduction; II. Genetic Implication of CNTN4, CNTN5, and CNTN6 in Neurodevelopment; III. Expression of Contactins During Brain Development; IV. Phenotypes in Contactin Null-Mutants; V. Structural Architecture of Contactins; VI. Protein-Protein Interactions Mediated by Contactins; VII. Final Remarks; Acknowledgments; References

Author IndexSubject Index

Notes:

Description based upon print version of record.

Includes bibliographical references and indexes.

ISBN:

1-283-24639-2

9786613246394

0-12-386484-4

OCLC:

775872049