Functional plasticity and genetic variation : insights into the neurobiology of alcoholism / edited by Matthew T. Reilly and David M. Lovinger.

Format:

Book

Contributor:

Reilly, Matthew T.

Lovinger. David M.

Series:

International review of neurobiology ; v. 91.

International review of neurobiology ; v. 91

Language:

English

Subjects (All):

Alcohol--Physiological effect.

Alcohol.

Alcoholism--Genetic aspects.

Alcoholism.

Brain--Effect of drugs on.

Brain.

Physical Description:

1 online resource (437 p.)

Place of Publication:

Amsterdam : Elsevier/Acadmic Press, 2010.

Language Note:

English

Summary:

Functional Plasticity and Genetic Variation

Contents:

Cover; International Review of Neurobiology; Copyright; Contents; Contributors; Preface; The Role of microRNAs in Drug Addiction: A Big Lesson from Tiny Molecules; I. Introduction; II. microRNA; III. microRNA and Alcohol; IV. Future Directions; V. Conclusions; References; The Genetics of Behavioral Alcohol Responses in Drosophila; I. Introduction; II. Ethanol Exposure in Flies; III. Genes and Biochemical Pathways Involved in Alcohol Responses; IV. Neural Circuits Involved in Ethanol Responses; V. Conclusions; References; Neural Plasticity, Human Genetics, and Riskfor Alcohol Dependence

I. IntroductionII. Brain Plasticity; III. The Case for Intermediate Phenotypes or Endophenotypes; IV. Brain Morphology as an Endophenotype for Alcohol Dependence Risk; V. Brain Functional Differences-Familial Risk and Developmental Stage; VI. Brain Structural and Functional Effects and Genetic Variation; VII. Conclusions; References; Using Expression Genetics to Study the Neurobiology of Ethanol and Alcoholism; I. Introduction; II. Genetic and Genomic Approaches in Alcohol Research; III. Genetic Analysis of Gene Expression; IV. Recognizing Biological Function in Genetical Genomics Studies

V. Current Problems and Future SolutionsAcknowledgments; References; Genetic Variation and Brain Gene Expression in Rodent Models of Alcoholism: Implications for Medication Development; I. Alcohol Addiction, Genetic Susceptibility, and Neuroadaptation; II. Animal Models and the Trajectory of Alcohol Addiction; III. Acute Pharmacological Responses to Alcohol; IV. Models of Genetic Susceptibility: Selected Rat Lines and Inbred Mouse Strains; V. Modeling Addiction-Related Neuroadaptations by Long-Term Alcohol Access or Forced Intoxication; VI. Conclusions; References

Identifying Quantitative Trait Loci (QTLs) and Genes (QTGs) for Alcohol-Related Phenotypes in MiceI. Introduction; II. Quantitative Trait Locus Mapping in Mice; III. High-Resolution QTL Mapping; IV. QTG Identification; V. In Vivo QTG Analyses; VI. Epistatic and Environmental Considerations in QTL Mapping; VII. Human Relevance of QTGs Identified in Mice; VIII. General Conclusions; Acknowledgments; References; Glutamate Plasticity in the Drunken Amygdala: The Makingof an Anxious Synapse; I. Introduction; II. Use-Dependent Synaptic Plasticity

III. Lateral/Basolateral Amygdala, Chronic Ethanol, and Glutamatergic Mechanisms Associated with Plasticity InitiationIV. Chronic Alcohol, Withdrawal, and the Expression of Synaptic Plasticity; V. Ethanol-Dependent Plasticity of Additional Amygdala Neurotransmitter Systems; VI. Conclusions and Future Directions; Acknowledgments.; References; Ethanol Action on Dopaminergic Neurons inthe Ventral Tegmental Area: Interaction with Intrinsic Ion Channels and Neurotransmitter Inputs; I. Introduction; II. The Mesolimbic DA System and Alcohol Drinking

III. Intrinsic and Synaptic Mechanisms Controlling DA Neuron Activity

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9786612879326

9781282879324

1282879324

9780123812773

0123812771

OCLC:

694146489