DNA arrays in neurobiology / edited by Michael F. Miles.

Format:

Book

Contributor:

Miles, Michael F.

Series:

International review of neurobiology ; v. 60.

International review of neurobiology ; v. 60

Language:

English

Subjects (All):

DNA microarrays.

Neurobiology.

Physical Description:

1 online resource (218 p.)

Place of Publication:

Amsterdam ; Boston : Elsevier Academic Press, c2004.

Language Note:

English

Summary:

DNA array technology is a technique for studying gene expression by comparing samples of different genes. The result is an enormous amount of data that must be carefully analyzed in order for it to be useful and meaningful. This book examines both data analysis and techniques for ensuring optimal experimental conditions. The array approach has applications in a number of model systems, including development, learning and drug abuse. In addition, the technique has applications in a number of neurological disorders such as Alzheimer's disease, schizophrenia, multiple sclerosis, and neurological

Contents:

Cover; Contents; Contributors; Introduction; Chapter 1. Microarray Platforms: Introduction and Application to Neurobiology; I. Introduction; II. Experimental Flow; III. Microarray Design; IV. Slides and Probes; V. Sample Preparation and Labeling; VI. Data Analysis; VII. Data Interpretation; VIII. Confirmation of Microarray Results; IX. Conclusion; X. Online Resources; References; Chapter 2. Experimental Design and Low-Level Analysis of Microarray Data; I. Introduction; II. Design of Experiments; III. Sample Size Considerations; IV. Normalization; V. Expression Summaries for GeneChip Data

VI. Quality AssessmentVII. Detection of Absolute Gene Expression; References; Chapter 3. Brain Gene Expression: Genomics and Genetics; I. Introduction; II. Transcript Abundance as a Complex Trait; III. Genetic Dissection of Transcription Regulation; IV. How Many QTLs Are There? Statistical Control in Two Dimensions; V. Probe Versus Probe Set-Level Phenotypes; VI. Transcription Regulatory Networks; VII. Functional Correlates of Brain Transcriptional Activity; VIII. Conclusions: Building a Model of Brain Function from Multipoint, Multi-tissue Gene Expression, and Phenomic Observation

ReferencesChapter 4. DNA Microarrays and Animal Models of Learning and Memory; I. Introduction; II. DNA Microarray Technology; III. Use of DNA Microarrays for Studying Learning and Memory; IV. Conclusion; References; Chapter 5. Microarray Analysis of Human Nervous System Gene Expression in Neurological Disease; I. Introduction; II. Disease Pathophysiology; III. Microarray-Based Disease Classification; IV. Human Neurological Diseases Studied by Microarray Technology; V. Conclusion; References; Chapter 6. DNA Microarray Analysis of Postmortem Brain Tissue; I. Introduction

II. Challenges in Studies of the Postmortem Human BrainIII. Microarray Analysis of Human Brain Disorders; IV. Where Do We Go from Here?; References; Index; Contents of Recent Volumes

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9786611011949

9781281011947

1281011940

9780080495514

0080495516

OCLC:

469606895