Advances in immunology. Volume 95 / edited by Frederick W. Alt.

Format:

• Book

Contributor:

• Alt, Frederick W.

Series:

• Advances in immunology ; 95.
• Advances in immunology ; 95

Language:

English

Subjects (All):

• Immunology.
• Microbiology.

Physical Description:

1 online resource (291 p.)

Place of Publication:

New York : Academic Press, 2007.

Language Note:

English

Summary:

Advances in Immunology, a long established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

Contents:

• Cover; Contents; Contributors; Chapter 1: Fate Decisions Regulating Bone Marrow and Peripheral B Lymphocyte Development; 1. Introduction; 2. B Lymphocyte Development in the Bone Marrow; 2.1. Stages of B lymphopoiesis; 2.2. Specification versus commitment during B lymphopoiesis; 2.3. Developmental checkpoints during B lymphopoiesis; 2.4. Selection for functional BCR complexes; 2.5. The hematopoietic microenvironment; 2.6. Permissive versus deterministic models of B lymphopoiesis; 2.7. Maintenance of early B lineage fate; 2.8. Perturbations affecting primary B lymphopoiesis
• 3. Development of Immature B Cells in the Bone Marrow and Periphery4. BCR-Dependent Signaling and Fate Decisions by Bone Marrow and Peripheral Immature B Lymphocytes; 4.1. Biochemistry of BCR-induced fate decisions during negative selection; 4.2. Alternative BCR-induced fate decisions; 5. BCR Signaling During the Transitional to Mature B-lymphocyte Transition; 5.1. Igalpha/beta and ITAMs; 5.2. B-cell linker protein; 5.3. Bruton's tyrosine kinase; 5.4. Involvement of other BCR-signaling proteins; 6. Peripheral B Lymphocyte Survival: Synergy Between BCR and BAFF-R Signaling
• 7. Development of FO and MZ Mature B Lymphocytes8. Concluding Remarks; Acknowledgments; References; Chapter 2: Tolerance and Autoimmunity: Lessons at the Bedside of Primary Immunodeficiencies; 1. Introduction; 2. PIDs Systematically Associated with Clinical AI; 2.1. Immunodysregulation, polyendocrinopathy, enteropathy X-linked syndrome (IPEX); 2.2. Autoimmune polyendocrinopathy, candidiasis, and ectodermal dystrophy (APECED); 2.3. Omenn syndrome (OS); 2.4. Autoimmune lymphoproliferative syndrome (ALPS); 2.5. Complement deficiencies; 3. PIDs Strongly Associated with Clinical AI
• 3.1. Selective IgA deficiency3.2. Common variable immunodeficiency; 3.3. Agammaglobulinemia; 3.4. Hyper-IgM syndrome; 3.5. Wiskott-Aldrich Syndrome; 3.6. NF-kappaB essential modulator defects; 4. PIDs that Are Mildly Associated with Clinical AI; 5. PIDs that Are Not Associated with AID; 6. Concluding Remarks; Addendum in proof; References; Chapter 3: B-Cell Self-Tolerance in Humans; 1. Antibody Diversity; 2. Antibodies and Self-Tolerance; 2.1. B-cell development and self-tolerance in the bone marrow; 2.2. Transitional B cells and peripheral selection of naive cells
• 2.3. Defective early B-cell tolerance checkpoints and autoimmunity2.4. Molecular defects associated with altered self-tolerance in autoimmunity; 3. Marginal Zone B Cells; 3.1. Mouse marginal zone B cells; 3.2. The human MZ and circulating IgM+ CD27+ B cells; 4. B-Cell Memory; 4.1. Germinal centers; 4.2. Activation and selection of autoreactive B cells; 4.3. Autoreactivity and B-cell memory; 5. Concluding Remarks; References; Chapter 4: Manipulation of Regulatory T-Cell Number and Function with CD28-Specific Monoclonal Antibodies; 1. Aims of this Review
• 2. Positive and Negative Regulation of T-Cell Responses by the CD28/CTLA-4 System

Notes:

• Description based upon print version of record.
• Includes bibliography and index.

ISBN:

• 9786611059408
• 9781281059406
• 1281059404
• 9780080553702
• 0080553702

OCLC:

476113003