Integrating the neurobiology of schizophrenia / edited by Anissa Abi-Dargham, Olivier Guillin.

Format:

• Book

Contributor:

• Abi-Dargham, Anissa.
• Guillin, Olivier.

Series:

• International review of neurobiology ; v. 78.
• International review of neurobiology ; v. 78

Language:

English

Subjects (All):

• Schizophrenia--Physiological aspects.
• Schizophrenia--Chemotherapy.

Physical Description:

1 online resource (476 p.)

Place of Publication:

Amsterdam ; London : Elsevier, c2007.

Language Note:

English

Summary:

This book examines the role that dopamine plays in schizophrenia, examining its role in not only the symptoms of the disease but also in its treatment. It also reviews all neurotransmitters that have been implicated in schizophrenia, exploring the genetic data, clinical data implicating the transmitter, and the preclinical data exploring how a transmitter may interact with dopamine and contribute to the dopaminergic phenotype observed in the illness. This book will serve as an educational tool for instructors, a guide for clinicians, and be of interest to researchers. It is a good reference f

Contents:

• Front Cover; Integrating the Neurobiology of Schizophrenia; Copyright Page; Contents; Contributors; Preface; References; Chapter 1: Neurobiology of Dopamine in Schizophrenia; I. Introduction; II. Dopaminergic System in the Brain; A. Dopaminergic Projections; B. Dopaminergic Receptors; III. Evidence Supporting Alterations of DA Systems in Schizophrenia; A. Pharmacological Evidence; B. Postmortem Studies; C. Imaging Studies; IV. Conclusions; References; Chapter 2: The Dopamine System and the Pathophysiology of Schizophrenia: A Basic Science Perspective; I. Introduction
• II. Neuroanatomy of DA SystemsIII. DA Neuron Activity and Release; IV. Cellular Actions of DA; V. Roles of DA on Cognitive and Affective Functions; VI. Development and Maturation of the DA System; VII. DA Deficits in Schizophrenia; VIII. Conclusions; References; Chapter 3: Glutamate and Schizophrenia: Phencyclidine, N-Methyl-D-Aspartate Receptors, and Dopamine-Glutamate Interactions; I. Introduction; II. Glutamatergic Physiology; A. Glutamate-Dopamine Comparisons; B. Glutamate Receptors; C. NMDA Receptors; D. AMPA/Kainate Receptors; E. Metabotropic Receptors
• III. Glutamatergic Models of SchizophreniaA. Symptom Patterns Following NMDA Antagonist Administration; B. Cognitive Deficits Following NMDA Antagonist Treatment; C. In Vivo Findings in Schizophrenia Based on Dopamine Receptor Occupancy; D. Postmortem Findings; IV. Clinical Studies with NMDA Agonists; A. NMDA Receptor Glycine-Site Agonists; B. Glycine Transport Inhibitors; C. Other Ionotropic Targets; D. Metabotropic Receptors; E. Group I Receptors; F. Group II Metabotropic Agonists; V. Potential Causes of Glutamatergic Dysfunction in Schizophrenia; A. Dopamine-Glutamate Interactions
• B. Linkage-Association Studies in SchizophreniaC. Environmental and Neurochemical Factors; VI. Future Research and Treatment Implications; Acknowledgments; References; Chapter 4: Deciphering the Disease Process of Schizophrenia: the.Contribution of Cortical Gaba Neurons; I. Working Memory Impairments: A Core Feature of Schizophrenia; II. Working Memory Impairments and Altered GABA Neurotransmission in the DLPFC; III. Potential Pathogenetic Mechanisms for Cell Type-Specific Alterations in GABA Neurons; A. Reduced Excitatory Drive via NMDA Receptors; B. Reduced Neurotrophin Signaling
• IV. Connecting Alterations in PV-Positive Neurons to Working Memory Impairments: Decreased Gamma Band Synchrony in SchizophreniaV. Treatment Implications; Acknowledgments; References; Chapter 5: Alterations of Serotonin Transmission in Schizophrenia; I. Introduction; II. Alteration of 5-HT Receptors in Schizophrenia; A. 5-HT Transporters; B. 5-HT1A Receptors; III. Pharmacological Manipulation of 5-HT Transmission in Schizophrenia; A. 5-HT Precursors; B. 5-HT Depleting Agents; C. 5-HT2 Receptors; C. 5-HT2A Agonism: LSD and ""Model"" Psychosis; D. Other Receptors
• D. 5-HT2A Antagonism, Clozapine, and Atypicality

Notes:

• Description based upon print version of record.
• Includes bibliographical references and index.

ISBN:

• 9786611003623
• 9781281003621
• 128100362X
• 9780080475080
• 0080475086

OCLC:

469445254