Advances in cancer research. Volume 98 / edited by George F. Vande Woude, George Klein.

Format:

Book

Contributor:

Vande Woude, George F.

Klein, George.

Series:

Advances in cancer research ; 98

Language:

English

Subjects (All):

Cancer--Research.

Cancer.

Oncology.

Physical Description:

1 online resource (279 p.)

Place of Publication:

New York : Academic Press, 2007.

Language Note:

English

Summary:

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. A very special event the Nobel Minisymposium, "Molecular Oncology - From Bench to Bedside,? held at the Karolinska Instituet, in Stockholm, Sweden, was marked the celebration of George and Eva Klein's combined 160th birthday. To honor this occasion, this 2nd of two volumes brings together contributions by their former students, colleagues and collaborators of the past fifty years into a volume of Advances in Cancer Research dedicated to George and Eva.

Contents:

Cover; Contents; Contributors to Volume 98; Foundations in Cancer Research; Chapter 1: Why Do We Not All Die of Cancer at an Early Age?; I. Introduction; II. Immune Surveillance; III. Genetic Surveillance (DNA Repair); IV. Intracellular Surveillance; V. Is There Epigenetic Surveillance?; VI. Intercellular Surveillance; VII. Summary; Acknowledgments; References; Foundations in Cancer Research; Chapter 2: The Early History of Plasma Cell Tumors in Mice, 1954-1976; I. Introduction; II. Plasma Cells Before the 1950s: Discovery, Uncertain Origins; III. Multiple Myeloma; IV. Abnormal Protein

V. New Ideas About the Cellular Basis of Antibody Formation in the 1950sVI. First PCTs in Mice; VII. Lloyd Law's Suggestion; VIII. X5563 and X5647; IX. Specific Induction of PCTs in Mice by Implanting Millipore Diffusion Chambers: Ruth Merwin and Thelma Dunn; X. Mineral Oil and the Hyperimmunization Hypothesis; XI. Discoveries on Antibody Structure Using Human Myeloma Proteins Changed the Course of Immunology, 1961-1965; XII. Enter Mel Cohn; XIII. Pneumococcal Type C Polysaccharide (PnC) and Phosphorylcholine; XIV. Herman Eisen, DNP, and MOPC315; XV. Irrelevant and Relevant Antigens

XVI. The Antidextrans, Antilevans, and AntigalactansXVII. Growing PCTs in Culture and Growth Factors; Acknowledgments; References; Foundations in Cancer Research; Chapter 3: Mouse Mammary Tumor Biology: A Short History; Abbreviations; I. Introduction; II. The Dawning of Experimental Cancer Research; A. The Origins of the Laboratory Mouse; B. The First Mouse Mammary Tumors; C. Spontaneous and Transplanted Tumors 1890-1911; III. Mendelian Mouse Genetics: 1909-1920; IV. The Inbred Mouse in Mouse Mammary Tumorigenesis: 1920-1930; V. The Extrachromosomal Factor: 1933-1940

VI. The Milk Agent 1936-1970A. Filterable Agent; B. Electron Microscopy; C. Infectivity Assays; D. The Natural History of Virus Infections; VII. MMTV and the Rise of Tumor Immunology; VIII. Hormones and the Emergence of Endocrinology; IX. The National Cancer Institute and the Birth of Molecular Biology: 1970-1980; A. Schools of Mouse Mammary Tumor Biology; B. The Emergence of Molecular Biology; C. The Search for a Human Breast Cancer Virus; D. MMTV and Molecular Oncology; X. Neoplastic Progression: 1954; XI. Neoplastic Progression: 1959 the HAN; A. The HAN; B. The Test-by-Transplantation

C. Comparative Pathology of PreneoplasiaD. Tumor Clonality; E. Developmental Biology and Neoplastic Progression: Mammary Stem Cells; XII. Genetically Engineered Mice: 1984-2006; A. Genetically Engineered Mice; B. Comparative Pathology of Breast Cancer; C. ""Validation"" of Mouse Models; D. Biotechnology and the Commercialization of Science; XIII. Epilog; Acknowledgments; References; Foundations in Cancer Research; Chapter 4: Ordered Heterogeneity and its Decline in Cancer and Aging; Abbreviations; I. Introduction; II. The Role of Tissue Size in Developmental Biology

III. Behavior of Dissociated Cells and Their Reassociation

Notes:

Description based upon print version of record.

ISBN:

9786611053567

9781281053565

1281053562

9780080488141

0080488145

OCLC:

476056115