Advances in immunology. Volume 92 / edited by Frederick W. Alt.

Format:

Book

Contributor:

Alt, Frederick.

Series:

Advances in immunology ; 92.

Advances in immunology ; 92

Language:

English

Subjects (All):

Immunology.

Microbiology.

Physical Description:

1 online resource (341 p.)

Place of Publication:

San Diego ; London : Elsevier, 2006.

Language Note:

English

Summary:

Advances in Immunology, a long established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

Contents:

Front Cover; Advances in Immunology; Copyright Page; Contents; Contributors; Chapter 1: Systemic Lupus Erythematosus: Multiple Immunological Phenotypes in a Complex Genetic Disease; Abstract; 1. Introduction; 2. Immunological Alterations in SLE; 3. Genetics of SLE Susceptibility in Humans; 4. Murine Models of SLE; 5. Modeling Disease Development; References; Chapter 2: Avian Models with Spontaneous Autoimmune Diseases; Abstract; 1. Introduction; 2. Chicken Genomics and Its Application to the Genetic Dissection of Autoimmune Disorders; 3. The OS Chicken: Model for Human Hashimoto Disease

4. The UCD-200 Line of Chickens: A Model for Human Systemic Sclerosis5. The SL Chicken Model for Human Autoimmune Vitiligo; 6. Conclusions and Outlook; Acknowledgments; References; Chapter 3: Functional Dynamics of Naturally Occurring Regulatory T Cells in Health and Autoimmunity; Abstract; 1. Introduction; 2. Phenotype of CD4+CD25+ nTreg Cells; 3. Factors Regulating the Expansion and Specificity of nTreg Cells; 4. Innate and Adaptive Inflammatory Signals Dictating the Function of nTreg Cells; 5. Growth Factor-Mediated Control of nTreg Cell Development, Function, and Homeostasis

6. Control of Autoimmune Responses by nTreg Cells7. Summary and Conclusions; Acknowledgments; References; Chapter 4: BTLA and HVEM Cross Talk Regulates Inhibition and Costimulation; Abstract; 1. Overview of BTLA and HVEM Ligand Discovery; 2. Structural Characterization of BTLA Bound to HVEM; 3. Viral Modulators of the HVEM-BTLA Pathway; 4. Expression and Regulation of BTLA, LIGHT, and HVEM on T Cells and APCs; 5. Mechanisms of the CD28 Family Inhibitory Receptors; 6. Consequences of HVEM Ligation; 7. BTLA and HVEM in Models of Disease; 8. Conclusions; References

Chapter 5: The Human T Cell Response to Melanoma AntigensAbstract; 1. Introduction; 2. Melanoma Antigens; 3. Measurement of Antigen-Specific T Cell Responses; 4. Naturally Acquired Tumor Antigen-Specific T Cell Responses; 5. Vaccine-Induced T Cell Responses; 6. Regulation of Tumor Antigen-Specific T Cell Responses; 7. Conclusions; Acknowledgments; References; Chapter 6: Antigen Presentation and the Ubiquitin-Proteasome System in Host-Pathogen Interactions; Abstract; 1. Host-Pathogen Interactions; 2. Manipulation of the Host Response by Pathogens: Some General Considerations

3. Antigen Presentation4. Class I MHC Antigen Presentation; 5. Pathogen Recognition by CD8+ T Cells and NK Cells; 6. Class II MHC Antigen Presentation; 7. Ubiquitin-Proteasome System; 8. The Ubiquitin Conjugation Cascade; 9. Ubiquitin Ligases; 10. Ubiquitin Chains and Ubiquitin-Like Modifiers (Ubls); 11. Deubiquitinating Enzymes; 12. The Proteasome; 13. ER Quality Control and Degradation; 14. ERAD Substrate Recognition; 15. ERAD E3 Ligases; 16. Mammalian ERAD E3s; 17. The Elusive Dislocon; 18. Driving Dislocation and the Ub-Binding Route to the Proteasome; 19. Peptide N-Glycanase

20. Viral Interference with Class I MHC Antigen Presentation

Notes:

Description based upon print version of record.

Includes bibliography and index.

ISBN:

9786610751617

9781280751615

1280751614

9780080469157

0080469159

OCLC:

703854320