Advances in cancer research. Volume 91 / edited by George F. Vande Woude, George Klein.

Format:

Book

Contributor:

Vande Woude, George F.

Klein, George.

Series:

Advances in cancer research ; 91

Language:

English

Subjects (All):

Cancer--Research.

Cancer.

Oncology--Research.

Oncology.

Physical Description:

1 online resource (219 p.)

Place of Publication:

Amsterdam : Academic Press, 2004.

Language Note:

English

Summary:

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics including

Contents:

Front Cover; Advances in Cancer Reasearch; Copyright Page; Contents; Contributors to Volume 91; Chapter 1. Imatinib as a Paradigm of Targeted Therapies; I. Introduction; II. Identification of the BCR-ABL Tyrosine Kinase as a Therapeutic Target; III. Development of an ABL-Specific Tyrosine Kinase Inhibitor; IV. Clinical Trials in CML; V. Mechanisms of Relapse; VI. Structural Basis of ABL Inhibition by Imatinib; VII. Activity of Imatinib in Other Indications; VIII. Lessons Learned from the Clinical Trials of Imatinib; IX. Translating the Success of Imatinib to Other Malignancies; References

Chapter 2. Prostate Cancer and the Met Hepatocyte Growth Factor ReceptorI. Hepatocyte Growth Factor/Scatter Factor-Met and Stromal-Epithelial Interactions in the Prostate; II. Met in Localized Prostate Cancer; III. Met in Prostate Cancer Metastasis; IV. Therapeutic Implications of Met Expression in Prostate Cancer; References; Chapter 3. Keratinocyte Growth Factor/Fibroblast Growth Factor 7, a Homeostatic Factor with Therapeutic Potential for Epithelial Protection and Repair; I. Introduction; II. Molecular Biology of KGF; III. Cellular and Molecular Responses to KGF; IV. Signal Transduction

V. Transgenic and Knockout ModelsVI. Regenerative and Protective Effects; VII. Clinical Trials. Amelioration of Severe Oral Mucositis; VIII. Concluding Remarks; References; Chapter 4. Histone Deacetylase Inhibitors; I. Chromatin Structure; II. Histone Deacetylases and Histone Acetyltransferases; III. Histone Deacetylases/Histone Acetyltransferases and Human Cancers; IV. Histone Deacetylase Inhibitors; V. Activity of Histone Deacetylase Inhibitors; VI. Clinical Trials with Histone Deacetylase Inhibitors; VII. Conclusions and Perspectives; References

Chapter 5. Raf-1 Kinase Inhibitor Protein. Structure, Function, Regulation of Cell Signaling, and Pivotal Role in ApoptosisI. Introduction. The Phosphatidylethanolamine-Binding Protein Family; II. Raf-1 Kinase Inhibitor Protein; III.Sigficance of rkip in Cancer; IV. Concluding Remarks; References; Index

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9786611010232

9781281010230

1281010235

9780080493473

0080493475

OCLC:

476067352