Advances in cancer research. Volume 83 / edited by George F. Vande Woude, George Klein.

Format:

Book

Contributor:

Vande Woude, George F.

Klein, George.

Language:

English

Subjects (All):

Cancer--Research.

Cancer.

Tumors--Research.

Tumors.

Physical Description:

1 online resource (273 p.)

Place of Publication:

San Diego : Academic Press, 2001.

Language Note:

English

Summary:

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics, including suppressor and oncogenic roles of TGF-b and its signaling pathways in tumorigenesis, hereditary diffuse gastric disease, the role of heparan sulfate proteoglycans in cell signaling and cancer, V-gene mutations in B-cell-derived human malignancy, MHC antigens and tumor escape from immune surveillance, the role of selection in progressive neoplastic transformation, and the g

Contents:

Front Cover; Advances in Cancer Research; Copyright Page; Contents; Contributors to Volume 83; Chapter 1. Suppressor and Oncogenic Roles of Transforming Growth Factor-ß and Its Signaling Pathways in Tumorigenesis; I. Introduction; II. The Tgf-ß Signaling Pathway; III. Bimodal Action of Tgf-ß in Tumorigenesis; IV. Activities of Tgf-ß Important for Oncogenesis; V. Dysregulated Expression or Activity of Components of Tgf-ß Signaling Pathways in Oncogenesis; VI. Summary; References; Chapter 2. Hereditary Diffuse Gastric Cancer; I. Introduction; II. Hereditary Diffuse Gastric Cancer

III. Mutations in CDH-1IV. The Tumor Spectrum of Hdgc; V. Inactivation of the Second CDH-1 Allele; VI. Molecular Mechanism of Hdgc Susceptibility; VII. Clinical Criteria and Management of Hdgc; VIII. Conclusion; References; Chapter 3. Role of Heparan Sulfate Proteoglycans in Cell Signaling and Cancer; I. Introduction; II. Hspgs and Cancer; III. Fgf Signaling and Hspgs in Drosophila; IV. Dpp Signaling and Hspgs in Drosophila; V. Wg and Hh Signaling and Hspgs in Drosophila; VI. The Role of Glypicans in Wg Signaling; VII. Hspgs Are Involved in Hh Movement; VIII. Conclusion; References

Chapter 4. The Occurrence and Significance of V Gene Mutations in B Cell-Derived Human MalignancyI. Introduction; II. Immunoglobulin Genes in Normal B Cell Development; III. Immunoglobulin Genes in B Cell Tumors; IV. Somatic Mutation in B Cell Tumors; V. Chronic Lymphocytic Leukemia; VI. Follicular Lymphoma; VII. Diffuse Large B Cell Lymphoma; VIII. Plasma Cell Tumors; IX. Conclusion; References; Chapter 5. Mhc Antigens and Tumor Escape from Immune Surveillance; I. Introduction; II. Hla Class I Antigen Expression in Primary Tumors

III. Changes in MHC Class I Antigen Expression during Metastatic ColonizationIV. T Cell Immunoselection of MHC Class I-Negative Tumor Clones; V. Expression of Nonclassical Hla Class I Molecules in Tumors; VI. Tumor Nk Escape Mechanisms; VII. Hla Class I Loss and T Cell-Based Immunotherapy; VIII. Hla Class II Antigens in Tumors; IX. Conclusions; References; Chapter 6. The Role of Selection in Progressive Neoplastic Transformation; I. Introduction; II. Spontaneous Neoplastic Transformation in Cell Culture; III. Selection in Transformation of Established Cell Lines

IV. The Contribution of Apoptosis to Selection in Neoplastic TransformationV. Inhibition of Growth of Transformed Cells by Surrounding Nontransformed Cells; VI. Confounding Effects of Variable Cell Behavior on the Dynamics of Transformation; VII. Summary of the Major Features of Spontaneous Transformation; VIII. Evidence for Selection in Experimental and Human Cancer; IX. Sources of Genetic Variation for Possible Selection in Tumor Development; X. The Nature of Selection in Vivo; XI. Selection in Carcinogenesis by Polycyclic Aromatic Hydrocarbons; XII. Conclusions; References

Chaptrt 7. Atm Genome Stability, Neuronal Development, and Cancer Cross Paths

Notes:

Description based upon print version of record.

ISBN:

9786611020590

9781281020598

1281020591

9780080522289

0080522289

OCLC:

476072952