Vitamin E / editor-in-chief, Gerald Litwack.

Format:

Book

Contributor:

Litwack, Gerald.

Series:

Vitamins and hormones ; v. 76.

Vitamins and hormones : advances in research and applications ; v. 76

Language:

English

Subjects (All):

Vitamin E.

Vitamins, Fat-soluble.

Physical Description:

1 online resource (611 p.)

Place of Publication:

Amsterdam ; Boston : Elsevier Academic Press, c2007.

Language Note:

English

Summary:

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molec

Contents:

Front Cover; Vitamin E; Copyright Page; Dedication Page; Contents; Contributors; Preface; Chapter 1: Vitamin E; I. Introduction; II. Vitamin E Structures and Function; III. Absorption, Transport, and Distribution to Tissues; A. Vitamin E Absorption; B. Requirement for Dietary Fat for Absorption; C. Requirement for Chylomicron Synthesis; D. Role of Exchange Proteins; E. Secretion of alpha-Tocopherol by the Liver; IV. The alpha-Tocopherol Transfer Protein; A. Structure and Localization; B. CRAL-TRIO Family; V. Regulation of Vitamin E Metabolism and Excretion; A. What Is CEHC?

B. Metabolism of Vitamin EC. Conjugation of CEHCs; D. Biliary Excretion of alpha-Tocopherol; E. Implications of Altered Xenobiotic Metabolism; VI. Implications for Humans Supplementing with Vitamin E; VII. Conclusion; Acknowledgments; References; Chapter 2: Structure and Function of alpha-Tocopherol Transfer Protein: Implications for Vitamin E Metabolism and AVED; I. Introduction; II. Structure of alpha-TTP; A. Crystallization; B. Overall Fold; C. Ligand Binding by alpha-TTP; D. An Open Conformation of alpha-TTP; III. Mutations Associated with AVED; A. Structural Considerations

B. Biochemical Characterization of AVED-Associated MutantsIV. Summary; References; Chapter 3: The alpha-Tocopherol Transfer Protein; I. Introduction; II. Identification of TTP; III. TTP and Vitamin E Status: Ataxia with Vitamin E Deficiency; IV. TTP and Vitamin E Status: TTP-/- Mice; V. Biochemical Activities of TTP; A. Specific, High-Affinity Binding of RRR-alpha-TOH; B. Facilitation of Ligand Transfer Between Lipid Vesicles; VI. Physiological Activities of TTP; VII. Three-Dimensional Structure of TTP; VIII. Selective Retention of RRR-alpha-TOH and the Evolutionary Origins of TTP

IX. EpilogueReferences; Chapter 4: Molecular Associations of Vitamin E; I. Introduction; II. Physical Properties of Vitamin E; III. Interaction of Vitamin E with Lipids in Monolayers; IV. Interaction of Vitamin E with Phospholipid Bilayer Membranes; V. Distribution and Orientation of Vitamin E in Phospholipid Membranes; VI. Motion of Vitamin E in Lipid Assemblies; VII. Effect of Vitamin E on Phospholipid Phase Behavior; VIII. Effect of Vitamin E on the Structure of Phospholipid Model Membranes; IX. Phase Separation of Vitamin E in Phospholipid Mixtures

X. Effect of Vitamin E on Membrane PermeabilityXI. Effect of Vitamin E on Membrane Stability; XII. Domains Enriched in Vitamin E in Membranes; XIII. Effect of Vitamin E on Membrane Protein Function; XIV. Conclusions; References; I. Introduction; II. Redox Cycling and Arylating Properties of Tocopherol Quinones; A. Redox Cycling; B. Arylation; III. Identification and Analysis of Tocopherols, Quinones, and Adducts; A. Tocopherols and Their Quinones; B. Thiol Nucleophile Adducts; IV. Arylating Tocopherol Quinones and the Unfolded Protein Response; V. Tocopherol Quinones and.Mutagenesis

VI. Specificity of Phenolic Antioxidant Precursors in Tocopherol Biology

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-281-11906-7

9786611119065

0-08-054906-3

OCLC:

808626158