Advances in immunology. Volume 93 / edited by Frederick W. Alt.

Format:

Book

Contributor:

Alt, Frederick W.

Series:

Advances in immunology ; v. 93.

Advances in immunology ; v. 93

Language:

English

Subjects (All):

Immunology.

Microbiology.

Physical Description:

1 online resource (306 p.)

Place of Publication:

New York : Academic Press, 2007.

Language Note:

English

Summary:

Advances in Immunology, a long established and highly respected serial, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

Contents:

Cover; Copyright Page; Contents; Contributors; Chapter 1: Class Switch Recombination: A Comparison Between Mouse and Human; 1. Introduction; 2. Mechanism of CSR; 2.1. Class Switch Recombination ""ABC""; 2.2. V(D)J Recombination and CSR; 2.3. CSR and Somatic Hypermutation; 2.4. Function of AID; 2.5. dU:dG Mismatches Processing and DNA DSB Resolution in CSR; 2.6. Regulation of CSR; 3. Comparison Between Human and Mouse; 3.1. The Constant Region Gene Locus in Human and Mouse; 3.2. Switch Regions in Human and Mouse; 3.3. 3' Enhancers in Human and Mouse; 3.4. AID in Human and Mouse

3.5. Regulation of CSR to IgA in Human and Mouse3.6. Regulation of CSR to IgG Subclasses in Human and Mouse; 3.7. CD40-CD40L Pathway in Human and Mouse; 3.8. BAFF-APRIL-TACI Pathway in Human and Mouse; 3.9. Toll and Toll-Like Receptor in Human and Mouse; 3.10. DNA Repair Factors and CSR; 4. Concluding Remarks; Notes added in proof; Acknowledgments; References; Chapter 2: Anti-IgE Antibodies for the Treatment of IgE-Mediated Allergic Diseases; 1. Introduction; 1.1. The Current Status of the Anti-IgE Development; 1.2. The Main Chemical Features of the Anti-IgE Therapeutic

1.3. IgE-Mediated Allergy Is a Vast Medical Field2. Rationale Leading to the Invention of the Anti-IgE Concept; 2.1. IgE Isotype-Specific Control and IgE Targeting; 2.2. The Unique Set of Anti-IgE-Binding Specificities; 2.3. Structural Basis of the Unique Binding Specificities; 2.4. Prevailing Concepts at the Time of the Invention; 3. Anti-IgE Is Approved for Treating Moderate-to-Severe Asthma; 3.1. ""Allergic Asthma"" Has Been Adopted as a New Clinical Indication; 3.2. Clinical Parameters Determined in the Clinical Studies

3.3. The Clinical Studies Confirm the Roles of IgE in the Pathogenesis of Asthma3.4. Analyses of Good Responders Among Asthma Patients; 4. Studies on Other Allergic Diseases; 4.1. Clinical Applications in Treating Allergic Rhinitis; 4.2. Anti-IgE Studies on Treating Peanut Sensitivity; 4.3. Clinical Application in Latex Sensitivity; 4.4. Allergic Diseases or Conditions for Which Anti-IgE Has Been Tested in Case Studies; 5. The Potential of Using Anti-IgE to Assist Allergen-Based Immunotherapy; 5.1. The Combination of Anti-IgE and SIT; 5.2. Priming Patients with Anti-IgE for Rush Immunotherapy

6. Pivotal Roles of IgE and FcepsivRI in Type I Hypersensitivity6.1. Stages Along IgE-Mediated Allergic Pathway; 6.2. Direct Pharmacological Effects of Anti-IgE; 7. Neutralization of Free IgE; 7.1. Total IgE and the Proportion of Allergen-Specific IgE; 7.2. IgE Concentration versus IgE Occupancy of FcepsivRI; 8. Downregulation of FcepsivRI; 8.1. The Dynamical Relationship Between Free IgE and FcepsivRI; 8.2. Anti-IgE as a Mast ""Cell-Stabilizing"" Agent; 8.3. How Low Should FcepsivRI-IgE Fall for a Mast Cell to Become Insensitive?

9. Potential Beneficial Effects of IgE:Anti-IgE Immune Complexes

Notes:

Description based upon print version of record.

Includes bibliographical references.

ISBN:

9786611003616

9781281003614

1281003611

9780080475073

0080475078

OCLC:

703858022