Proteins in eukaryotic transcription / edited by Ronald C. Conaway, Joan Weliky Conaway.

Format:

Book

Contributor:

Conaway, Ronald C.

Conaway, Joan Weliky.

Series:

Advances in protein chemistry ; v. 67.

Advances in protein chemistry ; v. 67

Language:

English

Subjects (All):

Genetic transcription--Regulation.

Genetic transcription.

Eukaryotic cells.

RNA polymerases.

Transcription factors.

Histones.

Physical Description:

1 online resource (276 p.)

Place of Publication:

Amsterdam ; Boston : Elsevier Academic Press, c2004.

Language Note:

English

Summary:

Protein Transcription is a key element of cellular and organ regulation. This volume covers structure and function of all major elements associated with transcription.*Mechanism of RNA polymerase I Transcription*Structure and function of RNA Polymerase II*Structure and function of the TFIID complex*Functional properties of Chromatin Remodeling Enzymes*Posttranslational modification

Contents:

Cover; Proteins in Eukaryotic Transcription; Copyright Page; CONTENTS; PREFACE; Chapter 1. Structure and Function of RNA Polymerase II; I. Perspective; II. Structure of RNA Polymerase II; III. Function of RNA Polymerase II; IV. Comparison with Other Polymerases; V. Conclusions; References; Chapter 2. The Mediator Complex; I. Summary; II. Saccharomyces cerevisiae Mediator; III. Mediator Complexes in Higher Eukaryotes; IV. Mechanism of Transcriptional Activation; V. Concluding Remarks; References; Chapter 3. Structure and Function of the TFIID Complex; I. TFIID and Transcription Initiation

II. TFIID Components and StructureIII. TFIID Functions; IV. The Requirement for TFIID In Vivo; V. Regulation of TFIID; VI. The TFIID-Chromatin Connection; VII. Future Questions; References; Chapter 4.Tetratricopeptide Repeats of TFC4 and a Limiting Step in the Assembly of the Initiation Factor TFIIIB; I. Introduction; II. Brf1-TFIIIC: A Limiting Interaction in Preinitiation Complex Assembly; III. Brf1-Tfc4 Interactions; IV. Bdp1-Tfc4 Interactions; V. Ligand Binding by TPR Arrays in Tfc4; VI. Ordered Binding of TFIIIB Subunits to TFIIIC-DNA and Dynamic Interactions with Tfc4

VII. Tfc4 and Other Pol III FactorsVIII. Conclusion; References; Chapter 5. Mechanism of RNA Polymerase I Transcription; I. Introduction; II. Ribosomal DNA Gene Structure; III. Species-Specificity of Ribosomal RNA Transcription; IV. Factors Involved in Ribosomal RNA Transcription; V. Assembly of an RNA Polymerase I Initiation Complex in Vertebrates; VI. Factors Required for RNA Polymerase I Transcription in Yeast; VII. Regulatory Mechanisms; VIII. Chromatin and RNA Polymerase I Transcription; IX. Conclusions; Acknowledgments; References

Chapter 6. Functional Properties of ATP-Dependent Chromatin Remodeling EnzymesI. Introduction; II. History of Nucleosome-Remodeling Complexes; III. Requirements for Nucleosome-Remodeling Enzymes; IV. Mechanisms of ATP-Dependent Chromatin Remodeling; V. Initiation of ATP-Dependent Chromatin Remodeling; VI. Conclusions; Acknowledgments; References; Chapter 7. Histone Acetyltransferase Proteins Contribute to Transcriptional Processes at Multiple Levels; I. Introduction; II. HATs and HAT Complexes: New Insights into HAT Regulation and Effects on Transcription

III. HAT Complexes Functionally Interact with Chromatin- Remodeling Complexes and Influence TranscriptionIV. HAT Proteins Function in Regulating Transcriptional Elongation; V. The Histone Code: Insights into Epigenetic Regulation of Transcription; VI. HATs: New Insight into Transcription and DNA Repair; VII. Conclusion and Perspectives; Acknowledgments; References; Chapter 8. Posttranslational Modifications of Histones by Methylation; I. Introduction; II. Lysine Methyltransferases; III. Arginine Methyltransferases; IV. Epilogue; References; Author Index; Subject Index

Notes:

Description based upon print version of record.

Includes bibliographical references and indexes.

ISBN:

1-281-02072-9

9786611020729

0-08-052241-6

OCLC:

469607933