Chloride movements across cellular membranes / volume editor, Michael Pusch.

Format:

Book

Contributor:

Pusch, Michael.

Series:

Advances in molecular and cell biology ; 38.

Advances in molecular and cell biology, 1569-2558 ; v. 38

Language:

English

Subjects (All):

Chloride channels.

Chlorides--Physiological transport.

Chlorides.

Cell membranes.

Physical Description:

1 online resource (389 p.)

Place of Publication:

Amsterdam ; London : Elsevier, 2007.

Language Note:

English

Summary:

All living cells are surrounded by a lipidic membrane that isolates them from the often harsh environment. However, to take up nutrients, to excrete waste, and to communicate among each other, Nature has invented an incredibly diverse set of transmembrane transport proteins. Specialized transporters exist to shuttle electrically charged ions, positive cations like sodium or negative anions like chloride, across the membrane. In the recent years, tremendous progress has been made in the field of chloride transport. The present book presents the state of the art of this rapidly expanding and int

Contents:

Front Cover; Chloride Movements Across Cellular Membranes; Copyright Page; Contents; Contributors; Preface; Chapter 1: Chloride-Transporting Proteins in Mammalian Organisms: An Overview; References; Chapter 2: Physiological Functions of the CLC Chloride Transport Proteins; I. Introduction; II. Physiological Function of CLC-0 and Mammalian CLC Proteins; III. CLC Proteins in Model Organisms; IV. Summary and Outlook; References; Chapter 3: Structure and Function of CLC Chloride Channels and Transporters; I. The Structure of CLC-ec1, A Bacterial CLC Transporter

II. Structural Conservation Among the CLCsIII. Ion Selectivity, Permeation and Binding; IV. A Multi-Ion Pore; V. Channels and Transporters: Where Is the Difference?; VI. Function of the CLC Transporters; VII. Speculative Modeling; VIII. CLC Channel Gating; IX. The Role of the C-Terminal Domain of CLC Channels: Recent Developments; X. Conclusions and Outlook; Acknowledgments; References; Chapter 4: Pharmacology of CLC Chloride Channels and Transporters; I. Introduction; II. The Pharmacology of the Macroscopic Skeletal Muscle Cl- Conductance gCl

III. New Molecules Targeting ClC-1 Identified Using Heterologous ExpressionIV. Mechanism of Block of Muscle Type CLC Channels by Clofibric Acid Derivatives; V. The Binding Site for 9-AC and CPA on ClC-1 and ClC-0 and Use of CPA as a Tool to Explore the Mechanism of Gating of ClC-0; VI. Pharmacology of CLC-K Channels; VII. Other CLC Channels and Other Blockers; VIII. Potential of Having Blockers of ClC-2, ClC-3, ClC-5, ClC-7: Outlook; Acknowledgments; References; Chapter 5: The Physiology and Pharmacology of the CFTR Cl- Channel; I. Introduction; II. The Molecular Physiology of CFTR

III. The Cellular Physiology of CFTRIV. The Role of CFTR in Epithelial Physiology; V. The Pathophysiology of CFTR; VI. The Pharmacology of CFTR; VII. Conclusions; Acknowledgments; References; Chapter 6: Gating of Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel; I. CFTR Overview; II. Regulation of CFTR by Phosphorylation/Dephosphorylation; III. CFTR Is an ATPase; IV. Structural Biology of ABC Transporters; V. Methods Used to Study CFTR Gating; VI. CFTR Gating by ATP; VII. Unsettled Issues and Future Directions; Acknowledgments; References

Chapter 7: Functional Properties of Ca2+-Dependent Cl- Channels and Bestrophins: Do They Correlate?I. Summary; II. Introduction; III. Functional Properties of CaCCs; IV. Molecular Candidates of CaCCs; V. Functional Properties of Bestrophins; VI. Concluding Remarks; Acknowledgments; References; Chapter 8: Cell Volume Homeostasis: The Role of Volume-Sensitive Chloride Channels; I. Introduction; II. Cell Volume Homeostasis; III. Volume-Sensitive Cl- Channels; IV. Concluding Remarks; References; Chapter 9: GABAergic Synaptic Transmission; I. Postsynaptic GABA Responses

II. Molecular Composition and Function of GABAergic/Glycinergic Synapses

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-281-00386-7

9786611003869

0-08-047534-5

OCLC:

476050774