Progress in medicinal chemistry. Volume 45 / edited by F.D. King and G. Lawton.

Format:

Book

Contributor:

King, Frank D.

Lawton, G. (Geoff)

Series:

Progress in medicinal chemistry ; 45

Language:

English

Subjects (All):

Pharmacology.

Pharmaceutical chemistry.

Physical Description:

1 online resource (233 p.)

Other Title:

Medicinal chemistry

Place of Publication:

Amsterdam : North-Holland Pub. Co. ; New York : American Elsevier Pub. Co., 2007.

Language Note:

English

Summary:

The success of any drug discovery project relies upon the quality of the lead that initiates the lead optimization process. What defines a 'quality lead', where these 'quality leads' come from and how one discovers them has been the subject of intense debate within the pharmaceutical industry, relies upon defining those properties that historically have led to successful drug discovery. This volume addresses these questions and specifically discusses diabetes, obesity and tuberculosis.*Presents the latest research in the field of drug discovery *Publishes on an annual basis to brin

Contents:

Cover; Progress in Medicinal Chemistry 45; Copyright Page; Contents; Preface; List of Contributors; Chapter 1. Hit and Lead Identification: Efficient Practices for Drug Discovery; Introduction; Hit and Lead Identification Practices; Lead Identification as Reported for Specific Targets; Conclusion; References; Chapter 2. DPPIV Inhibition: Promising Therapy for the Treatment of Type 2 Diabetes; Introduction; Medicinal Chemistry and Preclinical Studies; Clinical Data for Oral DPPIV Inhibitors; Conclusions; Authors Note; References

Chapter 3. Recent Progress Toward Nonpeptide Ligands for the Melanocortin-4 ReceptorIntroduction; Cyclohexylpiperidines as Potent MC4R Agonists; Cyclohexylpiperazines and Phenylpiperidines; Phenylpiperazines as MC4R Agonists; Other Classes of MC4R Agonists; Compounds Mimicking a-MSH and its Peptide Analogues; From Agonists to Antagonists; Small Molecule MC4R Antagonists from Initial Screen Hits; Other Nonpeptide MC4R Ligands; Interaction of the MC4R with Ligands; Medicinal Chemistry; Conclusion; References; Chapter 4. Tuberculosis Chemotherapy: Recent Developments and Future Perspectives

IntroductionTB Drug Development Pipeline; Potential New Drug Targets; Concluding Comments; Acknowledgments; References; Subject Index; Author Index (Vols. 1- 45); Subject Index (Vols. 1- 45)

Notes:

Description based upon print version of record.

Includes bibliographies and index.

ISBN:

9786610962655

9781280962653

1280962658

9780080471310

0080471315

OCLC:

476040821