Calcium : a matter of life or death / edited by Joachim Krebs, Marek Michalak.

Format:

Book

Contributor:

Krebs, J. (Joachim), 1940-

Michalak, Marek.

Series:

New comprehensive biochemistry ; v. 41.

New comprehensive biochemistry ; v. 41

Language:

English

Subjects (All):

Calcium--Physiological effect.

Calcium.

Calcium in the body.

Physical Description:

1 online resource (585 p.)

Edition:

1st ed.

Place of Publication:

Amsterdam ; Oxford : Elsevier, 2007.

Language Note:

English

Summary:

Calcium is a versatile carrier of signals regulating many aspects of cellular activity such as fertilization to create a new life and programmed cell death to end it. Calcium homeostasis is strictly controlled by channels, pumps and exchangers functioning as gates for calcium entry and release. Given that calcium is such a versatile messenger the field of calcium signaling is continuously and rapidly expanding. This book reviews the most recent developments in calcium signaling by leading experts in the field. It is a state-of-the-art summary of our present knowledge in this quickly growing

Contents:

Cover; Table of Contents; Preface; Other volumes in the series; List of contributors; Part 1 History and Evolution of Calcium Biochemistry; Chapter 1. The unusual history and unique properties of the calcium signal; 1. Preamble; 2. General principles of Ca2+ signaling; 3. Calcium is both a first and a second messenger; 4. The Ca2+ signal has autoregulatory properties; 5. The ambivalent nature of the Ca2+ signal; 6. Diseases originating from defects of Ca2+ sensor proteins; 6.1. A disease involving gelsolin; 6.2. Annexinopathies; 6.3. Calpainopathies

6.4. Dysfunctions of neuronal Ca2+ sensor proteins6.5. Calcium channelopathies; 6.5.1. The ryanodine receptor; 6.5.2. The plasma membrane voltage-gated Ca2+ channel; 6.6. Ca2+ pump defects; 7. Some final comments; References; Chapter 2. The evolution of the biochemistry of calcium; 1. Introduction; 2. Inorganic chemistry of Ca; 2.1. Model complex ion chemistry; 2.2. Exchange rates; 3. Primitive earth conditions; 4. Procaryote cellular chemistry: concentrations in the cytoplasm; 4.1. The first functions of Ca; 5. The initial single cell eucaryotes; 5.1. Early mineralization [11]

6. Multicellular eucaryotes6.1. Calcium in multicellular eucaryotes; 6.2. The extracellular matrix; 6.3. The extracellular fluids and later the nerves; 6.4. Animals with brains; 7. Minerals in higher organisms [11]; 8. The evolution of cytoplasmic proteins; 8.1. The structures of Ca-binding sites of proteins; 9. Connections to other metal ions; 10. Calcium and mankind; 11. Summary; References; Part 2 Structural and Functional Aspects of Calcium-Binding Proteins; Chapter 3. Calcium-binding proteins and the EF-hand principle; 1. Introduction; 2. Ca2+ ligation; 3. The EF-hand principle

4. Calcium in the extracellular space4.1. The calcium-binding EGF domain; 4.2. The extracellular calcium sensor; 4.3. The luminal calcium sensor stromal interaction molecule; 5. Intracellular calcium-binding proteins; 5.1. EF-hand-containing proteins; 5.1.1. Calcium-buffer proteins; 5.1.1.1. Parvalbumin; 5.1.1.2. Calbindin; 5.1.1.3. Calretinin; 5.1.2. Calcium sensor proteins; 5.1.2.1. Calmodulin; 5.1.2.2. Troponin C; 5.1.2.3. Centrins; 5.1.2.4. Neuronal calcium sensors; 5.1.2.5. S100 proteins; 5.1.2.5.1. Protein structures, metal binding, and interactions with target proteins

5.1.2.5.2. Biological functions5.1.2.5.3. S100 proteins and human diseases; 5.1.2.6. The penta EF-hand family; 5.2. Non-EF hand Ca2+-binding proteins; 5.2.1. Annexins; 5.2.2. C2-domain proteins; 6. Conclusions; References; Chapter 4. Structural aspects of calcium-binding proteins and their interactions with targets; 1. Introduction; 2. Calmodulin; 2.1. CaM structural topology; 2.2. CaM target proteins; 2.3. Conformational plasticity for target recognition by CaM; 2.4. Transcriptional regulation of CaM; 3. Neuronal Ca2+ sensor proteins; 3.1. NCS common structural topology

3.2. NCS target proteins

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-281-03450-9

9786611034504

0-08-055193-9

OCLC:

476102609