Glucose metabolism in the brain / edited by Donard Dwyer.

Format:

Book

Contributor:

Dwyer, Donard.

Series:

International review of neurobiology ; v. 51.

International review of neurobiology ; v. 51

Language:

English

Subjects (All):

Glucose--Metabolism.

Glucose.

Brain--Metabolism.

Brain.

Brain--Physiology.

Diabetes--Pathophysiology.

Diabetes.

Depression, Mental.

Physical Description:

1 online resource (570 p.)

Place of Publication:

Amsterdam ; Boston : Academic Press, c2002.

Language Note:

English

Summary:

Regulation of glucose at the biochemical level affects every area of the brain, and has impact from cellular to behavioral brain function. It plays an important role in diseases such as diabetes, stroke, schizophrenia and drug abuse as well as in normal and dysfunctional memory and cognition. This volume represents a thorough examination of all the major issues that are relevant to glucose metabolism by brain cells in relation to disease, combining basic research and clinical findings in a single, indispensable reference.Key Features* Serves as an essential reference on glucose me

Contents:

Front Cover; International Review of Neurobiology; Copyright Page; Contents; Contributors; Preface; Chapter 1. Energy Metabolism in the Brain; I. Introduction; II. Pathways and Regulation of Glucose Utilization; III. Relation Between Glucose Utilization and Function; IV. In vitro Studies of Stimulatory Mechanisms; V. Concluding Remarks; References.; Chapter 2. The Cerebral Glucose-Fatty Acid Cycle: Evolutionary Roots, Regulation, and (Patho)physiological Importance; I. Introduction.; II. Energy Homeostasis and the Glucose-Fatty Acid Cycle; III. The Evolutionary Roots of the Glucose-FA Cycle

IV. The Regulation of Brain Energy HomeostasisV. (Patho)physiological Importance of the Glucose-FA Cycle; VI. Conclusion; References; Chapter 3. Expression, Regulation, and Functional Role of Glucose Transporters (GLUTs) in Brain; I. Introduction; II. Structure of GLUTs; III. Survey of GLUT Distribution in the Brain; IV. Regulation of Glucose Transport in Brain; V. Conditions Associated with Modulation of GLUT Expression in Brain.; References; Chapter 4. Insulin-Like Growth Factor-1 Promotes Neuronal Glucose Utilization During Brain Development and Repair Processes; I. Introduction

II. The Insulin/IGF SystemIII. IGF/Insulin System Expression in the Brain; IV. IGF-1 and Brain Glucose Utilization; V. Effects of Transgenic IGF-1 Overexpression in Brain; VI. IGF-1 in the Primate Brain; VII. Summary; VIII. Future Directions; References; Chapter 5. CNS Sensing and Regulation of Peripheral Glucose Levels; I. Introduction; II. Where is Glucose Sensed?; III. How is Glucose Sensed?; IV. Why is Glucose Sensed?; V. How is Glucosensing Altered in Disease States?; VI. Summary and Conclusions; References; Chapter 6. Glucose Transporter Protein Syndromes; I. Introduction

II. Review of Glucose Metabolism and TransportIII. Human Diseases Associated with Defects of Glucose Transport; IV. Concluding Remarks; V. Future Directions; References; Chapter 7. Glucose, Stress, and Hippocampal Neuronal Vulnerability; I. Introduction.; II. Streptozotocin Diabetes as a Model of Increased Allostatic/Homeostatic Load; III. Diabetes, Stress, and Neuronal Glucose Homeostasis; IV. Stress, Diabetes, and Hippocampal Neuronal Activity: Behavioral Consequences; V. Future Perspectives; References; Chapter 8. Glucose/Mitochondria in Neurological Conditions; I. Introduction

II. Glucose TransportIII. Glycolysis; IV. The PDHC; V. The Krebs TCA Cycle; VI. Anaplerosis; VII. Disorders of the Electron Transport Chain; VIII. Impaired Mitochondrial Function in Other Disorders; IX. Summary and Conclusions; References; Chapter 9. Energy Utilization in the Ischemic/Reperfused Brain; I. Introduction; II. The Normoxic, Normoglycemic Brain; III. Metabolism in the Ischemic/Reperfused Brain; IV. Hyperglycemia, Diabetes, and Ischemic Injury; V. Insulin's Effects on Ischemic Injury; VI. Conclusions and Future Directions; References

Chapter 10. Diabetes Mellitus and the Central Nervous System

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9786611005313

9781281005311

1281005312

9780080491592

0080491596

OCLC:

476058964