Advances in cancer research. Volume 84 / edited by George F. Vande Woude, George Klein.

Format:

Book

Contributor:

Vande Woude, George F.

Klein, George.

Series:

Advances in cancer research ; 84

Language:

English

Subjects (All):

Cancer--Research.

Cancer.

Oncology.

Physical Description:

1 online resource (333 p.)

Place of Publication:

San Diego : Academic Press, 2002.

Language Note:

English

Summary:

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics, including gene expression in inherited breast cancer, multiparameter analyses of cell cycle regulation in tumorigenesis, Rho GTPases in transformation and metastasis, the myc oncogene, genetic requirements for the episomal maintenance of oncogenic herpesvirus genomes, treatment of Epstein-Barr virus-associated malignancies with specific T cells, the role of glycogen synthase kinase-

Contents:

Cover; Contents; Contributors to Volume 84; Chapter 1. Gene Expression in Inherited Breast Cancer; I. Introduction; II. Epidemiology of Familial Breast Cancer; III. The BRCA1 and BRCA2 Genes; IV. Tumor Progression and the Role of Estrogen in Breast Cancer Development; V. Characteristics of Hereditary Breast Cancers; VI. Other Causes of Breast Cancer; VII. Gene Expression Analysis; VIII. Concluding Remarks; References; Chapter 2. Multiparameter Analyses of Cell Cycle Regulatory Proteins in Human Breast Cancer: A Key to Definition of Separate Pathways in Tumorigenesis; I. Breast Cancer

II. Cell Cycle AberrationsIII. Deregulation of Some Important G1/S Regulatory Proteins in Breast Cancer; IV. Multiparameter Analyses of G1/S Regulatory Proteins in Breast Cancer; V. Future Perspectives; References; Chapter 3. Rho GTPases in Transformation and Metastasis; I. Introduction; II. Rho GTPases and Transformation; III. Rho GTPases and Metastasis; IV. Conclusions and Future Directions; References; Chapter 4. The myc Oncogene: MarvelouslY Complex; I. Introduction; II. Myc and Cancer; III. Biological Activities of Myc; IV. Functions of Myc as a Regulator of Transcription

V. Identification of Myc-Interacting ProteinsVI. Overall Perspectives; References; Chapter 5. Genetic Requirements for the Episomal Maintenance of Oncogenic Herpesvirus Genomes; I. Introduction; II. Latent Episomal Genomes of Oncogenic Herpesviruses; III. The Role of EBNA-1 and OriP in EBV Episomal Replication; IV. The Role of LANA1 and Terminal Repeats in Episomal Replication of KSHV and HVS; V. Conclusions; References; Chapter 6. Treatment of Epstein-Barr Virus-Associated Malignancies with Specific T Cells; I. Introduction; II. EBV-Associated Lymphoproliferative Disease

III. Hodgkin's DiseaseIV. Nasopharyngeal Carcinoma; V. Burkitt's Lymphoma; VI. EBV-Associated Non-Hodgkin's Lymphoma in HIV Patients; VII. Conclusions; References; Chapter 7. Role of Glycogen Synthase Kinase-3 in Cancer: Regulation by Wnts and Other Signaling Pathways; I. Origins of GSK-3; II. GSK-3 Functions: Clues From Other Species; III. Mammalian Wnt Signaling and Cancer 214; IV. Regulation of GSK-3 by Other Signaling Pathways; V. Other Targets of GSK-3 Involved in Cancer; VI. GSK-3 and Cancer; References

Chapter 8. Chronic Immune Activation and Inflammation in the Pathogenesis of AIDS and CancerI. The Pathogenesis of HIV-1 Infection; II. SIV and Simian AIDS; III. Chronic Immune Activation; IV. Immunological Imbalance in HIV Infection; V. Cancer and the Immune Response; VI. Kaposi's Sarcoma (KS) and HIV Infection as a Paradigm for Inflammatory Cancer Development; VII. The Interrelationship between the Immune Response and Angiogenesis; VIII. Inflammation and Apoptosis; IX. The Biology of Oncogenic Viruses: Impact on the Immune Response, Angiogenesis, and Apoptosis

X. Features of Tumors Lacking an Obvious Premalignant Inflammatory Process

Notes:

Description based upon print version of record.

ISBN:

9786611272609

9781281272607

1281272604

9780080569093

0080569099

OCLC:

476155200