Cofactor Biosynthesis : A Mechanistic Perspective

Format:

Book

Author/Creator:

Litwack, Gerald.

Contributor:

Begley, Tadgh.

Language:

English

Subjects (All):

Coenzymes.

Hormones--Synthesis.

Vitamins--Synthesis.

Local Subjects:

Coenzymes.

Hormones--Synthesis.

Vitamins--Synthesis.

Physical Description:

1 online resource (375 p.)

Place of Publication:

Burlington : Elsevier Science, 2001.

Language Note:

English

Summary:

The longest running serial published by Academic Press continues its well-respected run with Volume 61, a special volume in which a guest editor has come on board and has assembled some well-known contributors who are international authorities in the field. Together they tackle some of the latest topics in the field such as riboflavin and folate biosynthesis, biotin and lipoic acid biosynthesis, nicotinamide adenine dinucleotide biosynthesis, biosynthesis of vitamin B6 and structurally related derivatives, pantothenic acid and coenzyme A biosynthesis, mechanistic biosynthesis of protein

Contents:

Front Cover; Vitamins and Hormones; Copyright Page; Contents; Preface; Chapter 1. Biosynthesis of Riboflavin; I. Introduction; II. An Overview of the Riboflavin Biosynthetic Pathway; III. Riboflavin Is Formed from a Purine Precursor via Diaminopyrimidine Intermediates; IV. GTP Cyclohydrolase II; V. Reductase and Deaminase; VI. An Elusive Phosphatase; VII. 3,4-Dihydroxy-2-butanone 4-Phosphate Synthase; VIII. Lumazine Synthase; IX. Riboflavin Synthase; X. Riboflavin Synthase Paralogs in Bioluminescence; XI. Riboflavin Synthase of Archaebacteria

XII. The Lumazine Synthase/Riboflavin Synthase Complex of BacillaceaeXIII. Flavokinase and FAD Synthetase; XIV. Riboflavin Production by Fermentation; XV. Inhibitors of Riboflavin Biosynthesis; XVI. Biosynthesis of Riboflavin in Plants; XVII. Regulation of Riboflavin Biosynthesis in Bacillus subtilis; XVIII. Biosynthesis of 5-Deaza-7,8-didemethyl-8-hydroxyriboflavin; XIX. Biosynthesis of Molybdopterin; XX. Conclusion; References; Chapter 2. Biosynthesis of Biotin and Lipoic Acid; I. Biosynthesis of Biotin; II. Biosynthesis of Lipoic Acid; III. Conclusion; References

Chapter 3. The Biosynthesis of Nicotinamide Adenine Dinucleotides in BacteriaI. Introduction; II. The NAD(P) Biosynthetic Pathway in Bacteria; III. The Biosynthetic Enzymes; IV. The Enzymes of NAD(P) Recycling and Salvage; V. Regulation of NAD(P) Biosynthesis; VI. NAD(P) Biosynthesis in Eukaryotes; VII. NAD(P) in Human Nutrition; VIII. Summary and Conclusions; References; Chapter 4. Biosynthesis of Vitamin B6 and Structurally Related Derivatives; I. Introduction; II. Biosynthesis of Vitamin B6 in Escherichia coli; III. Biosynthesis of Ginkgotoxin in Ginkgo biloba; IV. Conclusions; References

Chapter 5. The Biosynthesis of Coenzyme A in BacteriaI. Introduction; II. The Coenzyme A Biosynthetic Pathway in Bacteria; III. Regulation of Coenzyme A Biosynthesis in Escherichia coli; IV. Coenzyme A Biosynthesis in Saccharomyces cerevisiae; V. Coenzyme A in Human Nutrition; VI. Summary and Conclusions; References; Chapter 6. Biosynthesis of Menaquinone (Vitamin K2) and Ubiquinone (Coenzyme Q): A Perspective on Enzymatic Mechanisms; I. Introduction; II. Menaquinone Biosynthesis; III. Ubiquinone Biosynthesis; IV. Biosynthesis of the Polyprenyl Side Chain

V. Comparison of Coenzyme Q Biosynthesis in Yeast and Escherichia coliVI. Conclusions; References; Chapter 7. Mechanisms of Biosynthesis of Protein-Derived Redox Cofactors; I. Introduction; II. Biological Significance; III. Discoveries of Protein-Derived Redox Cofactors; IV. Biogenesis of Trihydroxyphenylalanine Quinone; V. Biogenesis of Tryptophan Tryptophylquinone; VI. Biogenesis of Lysine Tyrosyl Quinone; VII. Biogenesis of the Cofactor in Galactose Oxidase; VIII. General Mechanistic Considerations; IX. Conclusion; References; Chapter 8. L-Ascorbic Acid Biosynthesis; I. Introduction

II. The Biosynthetic Pathway of Ascorbate in Mammals

Notes:

Description based upon print version of record.

ISBN:

1-281-02524-0

9786611025243

0-08-054453-3

OCLC:

437182082