Advances in immunology. Volume 96 / edited by Frederick W. Alt.

Format:

Book

Contributor:

Alt, Frederick W.

Series:

Advances in immunology ; 96.

Advances in immunology ; 96

Language:

English

Subjects (All):

Immunology.

Microbiology.

Physical Description:

1 online resource (234 p.)

Place of Publication:

New York, N.Y. : Academic Press, 2007.

Language Note:

English

Summary:

Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

Contents:

Cover; Contents; Contributors; Chapter 1: New Insights into Adaptive Immunity in Chronic Neuroinflammation; 1. Introduction: Multiple Sclerosis Is a Heterogeneous Inflammatory Disease of the Nervous System; 2. Experimental Autoimmune Encephalomyelitis as a Model for MS; 3. Current Knowledge About Induction and Perseveration of Chronic Neuroinflammation; 3.1. General considerations; 3.2. CD4+ T helper cells in chronic neuroinflammation; 3.3. CD8+ T cells in neuroinflammation: A never-ending controversy; 3.4. B cells and antibody-mediated immune responses in chronic neuroinflammation

4. Therapeutic Approaches to Chronic Neuroinflammation4.1. General considerations; 4.2. Current therapeutic concepts; 4.3. New therapeutic concepts; Acknowledgments; References; Chapter 2: Regulation of Interferon-gamma During Innate and Adaptive Immune Responses; 1. Introduction; 2. IFN-gamma-Producing Cells; 2.1. NK cells; 2.2. NKT cells; 2.3. CD8 T cells; 2.4. CD4 T cells play multiple roles in adaptive immunity; 3. Signaling Pathways Controlling IFN-gamma Production by NK Cells; 3.1. NK receptors provide a dynamic rheostat to control NK cell responses

3.2. IL-12 is a potent activator of IFN-gamma production in NK cells3.3. IL-15 and IL-2 regulate NK cell development and contribute to IFN-g production; 3.4. TGF-beta is a negative regulator of IFN-gamma production and NK cell development; 4. Control of IFN-gamma Production by NKT Cells; 5. Signaling Pathways in the Differentiation of CD4 and CD8 T Cells; 5.1. Naive T cells require antigen stimulation for proliferation and effector commitment; 5.2. T cells require cytokine signals for sustained IFN-gamma expression; 5.3. Other factors influencing Th1 lineage commitment

5.4. TGF-beta and IL-6 negatively regulate IFN-gamma production and Th1 development5.5. IFN-gamma production by memory T cells in response to cytokine stimulation; 6. Transcription Factors Downstream of the TCR, Activating NK Receptors, and Cytokine Receptors; 6.1. Factors downstream of the TCR, costimulatory, and activating NK receptors; 6.2. STATs are activated in response to cytokine receptor signaling; 6.3. T-box family members are crucial for IFN-gamma secretion; 7. Epigenetic Processes Govern Plasticity of Cell Fate Choices and Help to Identify Distal Regulatory Elements

8. Transcriptional Regulatory Elements Within the Ifng Gene8.1. Regulatory elements within the Ifng promoter and gene; 8.2. Identification of candidate distal regulatory elements in the Ifng locus; 9. Functional Analysis of Candidate Distal Regulatory Elements in the Ifng Locus; 10. Conclusions and Future Directions; Acknowledgments; References; Chapter 3: The Expansion and Maintenance of Antigen-Selected CD8+ T Cell Clones; 1. Background; 1.1. Introduction; 1.2. Subsets of antigen-selected CD8+ T cells: Central memory, effector memory, and effector cells

1.3. Central memory CD8+ T cells generate new effector CD8+ T cells

Notes:

Description based upon print version of record.

ISBN:

9786611055493

9781281055491

1281055492

9780080554914

0080554911

OCLC:

476129089