The pharmacology of neurogenesis and neuroenhancement / edited by Donald S. Dwyer.

Format:

Book

Contributor:

Dwyer, Donald S.

Series:

International review of neurobiology ; v. 77

Language:

English

Subjects (All):

Brain chemistry.

Neurobiology.

Pharmacology, Experimental.

Physical Description:

1 online resource (344 p.)

Place of Publication:

San Diego, CA : Academic Press, c2007.

Language Note:

English

Summary:

Currently, few drugs are available for the effective treatment of neurodegenerative diseases and neurodevelopmental disorders. Recent advances in neuroscience research offer hope that future strategies for treating these brain disorders will include neurogenesis and neuroenhancement as therapeutic endpoints. This volume reviews cutting-edge findings related to the pharmacological aspects of neurogenesis and neuroprotection. A broad range of topics are covered from basic lab bench research to drug discovery efforts and important clinical issues. This collection of reviews is a perfect way t

Contents:

Front Cover; The Pharmacology of Neurogenesis and Neuroenhancement; Copyright Page; Table of Contents; Contributors; Preface; Chapter 1: Regenerating the Brain; I. Introduction; II. Neurodegenerative Diseases: Therapeutic Targets for Neurogenesis; III. Building Brains: Evolution and Development; IV. Endogenous and Exogenous Sources of New Neurons; V. Endogenous Adult Neurogenesis; VI. Injury-Induced Neurogenesis; VII. Neurogenesis in Stroke; VIII. Neurogenesis in AD; IX. Neurogenesis in HD; X. Neurogenesis in PD; XI. Neurogenesis in Motor Neuron Disease

XII. Convergent and Divergent Features of Injury-Induced NeurogenesisXIII. Unanswered Questions; Acknowledgments; References; Chapter 2: Serotonin and Brain: Evolution, Neuroplasticity, and Homeostasis; I. Introduction; II. Evolution: From Unicellular to Humans; III. Holistic Brain Function Starts at Development; IV. Homeostasis of Brain; V. Clinical Implications of Loss of Homeostasis; References; Chapter 3: Therapeutic Approaches to Promoting Axonal Regeneration in the Adult Mammalian Spinal Cord; I. Introduction; II. Growth-Inhibiting Properties of the Glial Scar

III. Inhibition of Axonal Regeneration by CNS MyelinIV. Cell-Based Strategies to Promote Regeneration; V. Future Directions; References; Chapter 4: Evidence for Neuroprotective Effects of Antipsychotic Drugs: Implications for the Pathophysiology and Treatment of Schizophrenia; I. Introduction; II. Altered Levels of NTs and Their Receptors by Antipsychotic Drugs; III. The Regulation of Neurogenesis by Antipsychotic Drugs; IV. Neuroprotective Effects of Antipsychotic Drugs; Acknowledgments; References

Chapter 5: Neurogenesis and Neuroenhancement in the Pathophysiology and Treatment of Bipolar DisorderI. Introduction; II. Clinical Evidence for a Role of Neuroplasticity in BPD; III. Preclinical In Vivo and In Vitro Studies; IV. Conclusions; References; Chapter 6: Neuroreplacement, Growth Factor, and Small Molecule Neurotrophic Approaches for Treating Parkinson's Disease; I. Introduction; II. Etiology of PD; III. Current Treatment for PD; IV. Rodent Models of PD Used to Evaluate Putative Neuroprotective Therapies; V. Approaches to Brain Repair in PD; VI. Summary and Conclusions

AcknowledgmentsReferences; Chapter 7: Using Caenorhabditis elegans Models of Neurodegenerative Disease to Identify Neuroprotective Strategies; I. Introduction; II. C. elegans Models of Neurodegenerative Disorders; III. Identifying Candidate Modifier Genes of Neurodegeneration; IV. Molecular Inhibitors of Neurodegeneration; V. Neuroprotective Strategies; VI. Utility of HTS for Drugs in Worms; VII. Conclusions; References; Chapter 8: Neuroprotection and Enhancement of Neurite Outgrowth With Small Molecular Weight Compounds From Screens of Chemical Libraries; I. Introduction

II. Brain Deficit Disorders: The Challenges

Notes:

Description based upon print version of record.

Includes bibliographies and index.

ISBN:

9786610751655

9781280751653

1280751657

9780080469188

0080469183

OCLC:

476037328