Basic biology and clinical impact of immunosenescence / volume editor, Graham Pawelec.

Format:

Book

Contributor:

Pawelec, G. (Graham)

Series:

Advances in cell aging and gerontology ; v. 13.

Advances in cell aging and gerontology, 1566-3124 ; v. 13

Language:

English

Subjects (All):

Immune system--Aging.

Immune system.

Physical Description:

1 online resource (323 p.)

Place of Publication:

Amsterdam ; Boston : Elsevier, 2003.

Language Note:

English

Summary:

Ageing is of perennial interest as a universal feature in all human societies. The genetic background and biochemical bases of ageing processes are currently being revealed in unprecedented detail. It is emerging that one of the main hurdles to be overcome in achieving a long and healthy lifespan is the maintenance of a properly functioning immune system. The main cause of death in people who have achieved ""successful ageing"" (which mostly means not having succumbed to cancer or cardiovascular disease) is infectious disease, caused by immunosenescence. This book contains chapters by many of

Contents:

Cover; Table of Contents; Preface; Chapter 1. The OCTO and NONA Immune Longitudinal Studies: A Review of 11 years Studies of Swedish very old humans; Chapter 2. Immune Measures which Predict 9-Year Survival in an Elderly Population Sample; Chapter 3. Immunological and Immunogenetic Markers of Successful and Unsuccessful Ageing; Chapter 4. Developmental Aspects of the Thymus in Aging; Chapter 5. Effective Immunity During Late Life; A Possible Role for the Thymus; Chapter 6. Alterations in Signal Transduction in T Lymphocytes and Neutrophils with Ageing

Chapter 7. CD28 Downregulation and Expression of NK-Associated Receptors on T Cells in Aging and Situations of Chronic Activation of the Immune SystemChapter 8. Characterisation of NK Cells in the Elderly; Chapter 9. T Cell Ageing and Immune Surveillance; Chapter 10. A Road to Ruins: An Insight Into Immunosenescence; Chapter 11. Genetic Damage and Ageing T Cells; Chapter 12. Role of DNA-dependent Protein Kinase (DNA-PK), A Protein with Multiple Intracellular Functions, in Cells of the Ageing Immune System

Chapter 13. Linker Histone H1o Gene Expression During Ageing and After the Effect of Histone Deacetylase Inhibitors in Human Diploid Fibroblasts and T LymphocytesChapter 14. Zinc and the Immune System of Elderly; Chapter 15. Altered Zinc Binding by Metallothioneins in Immune-Neuroendocrine Senescence: A Vicious Circle Between Metallothioneins and Chaperones?; Chapter 16. T Cell Exhaustion and Aging: Is Replicative Senescence Relevant?; Chapter 17. Cultured T cell Clones as Models for Immunosenescence; Contributor Addresses

Notes:

Description based upon print version of record.

Includes bibliographical references.

ISBN:

1-281-02737-5

9786611027377

0-08-054648-X

OCLC:

703870837