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Immunopathogenesis of type 1 diabetes mellitus / edited by Emil R. Unanue, Hugh O. McDevitt.
- Format:
- Book
- Series:
- Advances in immunology ; v. 100.
- Advances in immunology ; 100
- Language:
- English
- Subjects (All):
- Diabetes--Immunological aspects.
- Diabetes.
- Diabetes--Pathogenesis.
- Physical Description:
- 1 online resource (206 p.)
- Place of Publication:
- Amsterdam ; Boston : Academic, 2008.
- Language Note:
- English
- Summary:
- Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. This thematic volume focuses on the immunopathogenesis of type 1 diabetes mellitus. Edited and authored by the foremost scientists in this field, it provides up-to-date information and directions for future research.
- Contents:
- Front Cover; Advances in Immunology; Copyright Page; Contents; Contributors; Chapter 1: Autoimmune Diabetes Mellitus-Much Progress, but Many Challenges; 1. Models of Type 1 DM; 4. The Genetics of Type 1 Diabetes; References; Chapter 2: CD3 Antibodies as Unique Tools to Restore Self-Tolerance in Established Autoimmunity: Their Mode of Action and Clinical Application in Type 1 Diabetes; 3. The Clinical Results in T1D: More than 25 Years of Effort; 4. Why is the Effect of CD3-Antibody Based Therapy Antigen Specific and Long Lasting?; Chapter 3: GAD65 Autoimmunity-Clinical Studies
- 1. IntroductionChapter 4: CD8+ T Cells in Type 1 Diabetes; 3. Autoreactive CD8+ T Cells in T1D; 5. The Relative Contribution of the beta-Cell-Specific CD8+ Response to T1D; 7. Recruitment of Diabetogenic CD8+ T Cells to Islets; 9. Induction of Immunologic Tolerance in Diabetogenic CD8+ T Cells; Acknowledgments; References; Chapter 5: Dysrulation of T Cell Peripheral Tolerance in Type 1 Diabetes; 3. Dysregulation of Central T Cell Tolerance in T1D; 4. Dysregulation of Peripheral T Cell Tolerance in T1D; 5. Summary; Chapter 6: Gene-Gene Interactions in the NOD Mouse Model of Type 1 Diabetes
- 4. Functional Studies with NOD Congenic Mice: The Combination of Protective Alleles at Idd3 and Idd5 Prevent DiabetAcknowledgments; References; Subject Index; Contents of Recent Volumes; Color Plates
- Notes:
- Description based upon print version of record.
- Includes bibliographical references and index.
- ISBN:
- 9786612287039
- 9781282287037
- 1282287036
- 9780080921730
- 0080921736
- OCLC:
- 476255358
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