Advances in cancer research. Volume 102 / edited by George F. Vande Woude, George Klein.

Format:

Book

Contributor:

Vande Woude, George F.

Klein, George.

Series:

Advances in cancer research ; v. 102

Language:

English

Subjects (All):

Cancer--Research.

Cancer.

Tumors.

Physical Description:

1 online resource (253 p.)

Place of Publication:

Amsterdam ; Boston : Elsevier/AP, c2009.

Language Note:

English

Summary:

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, including tumor dormancy, micro RNA, tumor angiogenesis, cancer in mouse models, liposome based chemo and autoimmunotherapy, signaling in angiogenesis, targeted cancer therapy, and regulatory t-cells.

Contents:

Front Cover; Advances in Cancer Research; Copyright; Contents; Contributors; Chapter 1: Ras Signaling and Therapies; I. Introduction: The Ras Superfamily and Their Regulators; II. The Raf/MAPK Pathway; III. Ras and the PI3K Pathway; V. Ras and Neurofibromatosis; VI. Therapeutic Opportunities; References; Chapter 2: PI3K/PTEN Signaling in Angiogenesis and Tumorigenesis; I. Introduction of PI3K/PTEN Signaling Pathway; II. Angiogenesis Regulated by VEGF, Angiopoietins, and PI3K Activation; III. Genetic Aberrations of PI3K, PTEN, and AKT in Cancer

IV. Roles of PI3K and AKT in Regulating AngiogenesisV. PI3K/PTEN Controls Angiogenesis through Increasing HIF-1 and VEGF Expression; VI. The Downstream Signaling Molecules Mediated by PI3K/PTEN in Regulating Tumor Growth and Angiogenesis; VIII. Concluding Remarks; Chapter 3: Tumor Dormancy and Metastasis; I. Introduction-The Clinical Problem; II. Experimental Studies of Tumor Dormancy; III. Clinical Approaches to Metastasis and Dormancy; IV. Future Implications; References; Chapter 4: Histone Demethylases and Cancer; II. Histone Methylation and Chromatin Structure

III. Histone Methylation and CancerIV. Histone Demethylases as Therapeutic Targets; V. Concluding Remarks; References; Chapter 5: Sirtuins and p53; II. Sirtuins and Disease; III. Sirtuins Levels and Activity in Cancer Cells; VI. Sirtuin Inhibition and p53; Chapter 6: Oxidative Stress and Lymphocyte Persistence: Implications in Immunotherapy; I. Introduction; II. Oxidative Stress; III. Lymphocyte Subsets, Immune Functions, and Persistence; IV. Mechanisms for Differential Susceptibility; V. Redox Regulation and Signaling; VI. Rescue of Lymphocytes from Oxidative Stress-Induced Apoptosis

VII. Future Clinical Developments to Improve Tumor Immunity by Prolonging the Life Span of Effector T Cells and NK CellsVIII. Conclusion; Index; Color Plates

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9786612285547

9781282285545

1282285548

9780080922331

0080922333

OCLC:

303020757