Biothermodynamics. Part C / edited by Michael L. Johnson, Jo M. Holt and Gary K. Ackers.

Format:

Book

Contributor:

Johnson, Michael L.

Holt, Jo M.

Ackers, Gary K.

Series:

Methods in enzymology ; v. 488.

Methods in enzymology, 0076-6879 ; v. 488

Biothermodynamics

Language:

English

Subjects (All):

Thermodynamics.

Biochemistry.

Physical Description:

1 online resource (xlv, 354 p., [7] p. of plates) : ill. (some col.).

Edition:

1st ed.

Place of Publication:

Amsterdam : Elsevier, 2011.

Summary:

In the past several years, there has been an explosion in the ability of biologists, molecular biologists and biochemists to collect vast amounts of data on their systems. Biothermodynamics, Part C presents sophisticated methods for estimating the thermodynamic parameters of specific protein-protein, protein-DNA and small molecule interactions. The use of thermodynamics in biological research is used as an "energy book-keeping system." While the structure and function of a molecule is important, it is equally important to know what drives the energy force. These methods look to answer: What are the sources of energy that drive the function? Which of the pathways are of biological significance? As the base of macromolecular structures continues to expand through powerful techniques of molecular biology, such as X-ray crystal data and spectroscopy methods, the importance of tested and reliable methods for answering these questions will continue to expand as well. Elucidates the relationships between structure and energetics and their applications to molecular design, aiding researchers in the design of medically important molecules Provides a "must-have" methods volume that keeps MIE buyers and online subscribers up-to-date with the latest research Offers step-by-step lab instructions, including necessary equipment, from a global research community

Notes:

Includes bibliographical references and indexes.

ISBN:

9786612968884

9781282968882

1282968882

9780123812698

0123812690