Computer methods. Part A / edited by Michael L. Johnson, Ludwig Brand.

Format:

Book

Contributor:

Johnson, Michael L., 1947-

Brand, Ludwig.

Series:

Methods in enzymology ; 454.

Methods in enzymology ; 454

Language:

English

Subjects (All):

Biomedical engineering--Computer simulation.

Biomedical engineering.

Enzymology.

Physical Description:

1 online resource (491 p.)

Place of Publication:

Amsterdam ; Boston : Elsevier, 2009.

Language Note:

English

Summary:

The combination of faster, more advanced computers and more quantitatively oriented biomedical researchers has recently yielded new and more precise methods for the analysis of biomedical data. These better analyses have enhanced the conclusions that can be drawn from biomedical data, and they have changed the way that experiments are designed and performed. This volume, along with previous and forthcoming 'Computer Methods' volumes for the Methods in Enzymology serial, aims to inform biomedical researchers about recent applications of modern data analysis and simulation methods as app

Contents:

Front Cover; Computer Methods, Part A; Copyright Page; Contents; Contributors; Preface; Methods in Enzymology; Chapter 1: Phase Response Curves: Elucidating the Dynamics of Coupled Oscillators; 1. Introduction; Appendix I; Appendix II; Chapter 2: Multiple Ion Binding Equilibria, Reaction Kinetics, and Thermodynamics in Dynamic Models of Biochemical Pathways; 2. Biochemical Conventions and Calculations; 3. Application to Physiological Systems; Chapter 3: Analytical Methods for the Retrieval and Interpretation of Continuous Glucose Monitoring Data in Diabetes; 1. Introduction

2. Decomposition of Sensor Errors3. Measures of Average Glycemia and Deviation from Target; 5. Measures and Plots of System Stability; 7. Conclusions; Chapter 4: Analysis of Heterogeneity in Molecular Weight and Shape by Analytical Ultracentrifugation Using Parallel Distributed Computing; 1. Introduction; 3. Job Submission; 5. Conclusions; Acknowledgments; Chapter 5: Discrete Stochastic Simulation Methods for Chemically Reacting Systems; 1. Introduction; 2. The Chemical Master Equation; 3. The Stochastic Simulation Algorithm; 5. Measurement of Simulation Error

Chapter 6: Analyses for Physiological and Behavioral Rhythmicity1. Introduction; 2. Types of Biological Data and their Acquisition; 5. Time/Frequency Analysis and the Wavelet Transform; 7. Strength and Regularity of a Signal; 8. Conclusions; References; Chapter 7: A Computational Approach for the Rational Design of Stable Proteins and Enzymes: Optimization of Surface Charge-Charge Interactions; 1. Introduction; 2. Computational Design of Surface Charge-Charge Interactions; Acknowledgments; References

Chapter 8: Efficient Computation of Confidence Intervals for Bayesian Model Predictions Based on Multidimensional Parameter Space1. Introduction; 2. Height of the Probability Density Function at the Boundary of the Smallest Multidimensional Confidence Region; 3. Approximating a One-Dimensional Slice of the Probability Density Function by Means of Normal Curve Spline Pieces; 6. An Application: Bayesian Forecasting of Cognitive Performance Impairment during Sleep Deprivation

Chapter 9: Analyzing Enzymatic pH Activity Profiles and Protein Titration Curves Using Structure-Based pKa Calculations and Titration Curve Fitting3. Setting up and Running a pKa Calculation; 5. How Reliable are Calculated pKa Values?; 6. Predicting pH Activity Profiles; References; Chapter 10: Least Squares in Calibration: Weights, Nonlinearity, and Other Nuisances; 1. Introduction; 2. Review of Least Squares; 3. Experiment Design Using Vprior - Numerical Illustrations; References; Chapter 11: Evaluation and Comparison of Computational Models; 1. Introduction; 3. Model Comparison Methods

Acknowledgments

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9786612285646

9781282285644

1282285645

9780080923291

0080923291

OCLC:

302408753