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Quinones and quinone enzymes. Part B / edited by Helmut Sies, Lester Packer.
- Format:
- Book
- Series:
- Methods in enzymology ; v. 382.
- Methods in enzymology ; v. 382
- Language:
- English
- Subjects (All):
- Quinone.
- Enzymes--Analysis.
- Enzymes.
- Physical Description:
- 1 online resource (611 p.)
- Place of Publication:
- San Diego, CA : Elsevier Academic Press, c2004.
- Language Note:
- English
- Summary:
- Quinones are members of a class of aromatic compounds with two oxygen atoms bonded to the ring as carbonyl groups. This volume covers more clinical aspects of quinines, such as anticancer properties, as well as their role in nutrition and in age-related diseases.*Mitochondrial Ubiquinone and Reductases*Anticancer Quinones and Quinone Oxido-Reductases*Quininone Reductases: Chemoprevention, Nutrition*Quinones and Age-Related Diseases
- Contents:
- Cover; Table of Contents; Contributors to Volume 382; Preface; Volumes in Series; Section I: Mitochondrial Ubiquinone and Reductases; Chapter 1. Mitochondrial Quinone Reductases: Complex I; Chapter 2. Q-cycle Bypass Reactions at the Qo Site of the Cytochrome bc1 (and Related) Complexes; Chapter 3. Targeting Coenzyme Q Derivatives to Mitochondria; Chapter 4. The Mitochondrial Interplay of Ubiquinol and Nitric Oxide in Endotoxemia; Chapter 5. Mitochondrial Respiratory Chain Dysfunction Caused by Coenzyme Q Deficiency; Chapter 6. Coenzyme Q Cytoprotective Mechanisms
- Chapter 7. Dietary Coenzyme Q10 and Mitochondrial StatusSection II: Anticancer Quinones and Quinone Oxidoreductases; Chapter 8. NAD(P)H: Quinone Oxidoreductase 1 (NQO1, DT-Diaphorase), Functions and Pharmacogenetics; Chapter 9. Structure and Mechanism of NAD[P]H: Quinone Acceptor Oxidoreductases (NQO); Chapter 10. Diaziridinylbenzoquinones; Chapter 11. Quinone Reductase-Mediated Nitro-Reduction: Clinical Applications; Chapter 12. Bioactivation and Resistance to Mitomycin C; Chapter 13. NAD(P)H:Quinone Oxidoreductase 1 Expression, Hydrogen Peroxide Levels, and Growth Phase in HeLa Cells
- Chapter 14. The ''Prochaska'' Microtiter Plate Bioassay for Inducers of NQO1Chapter 15. Structure-Activity Relationships in Two-Electron Reduction of Quinones; Chapter 16. p53-Dependent Apoptosis and NAD(P)H:Quinone Oxidoreductase 1; Chapter 17. The Role of Endogenous Catechol Quinones in the Initiation of Cancer and Neurodegenerative Diseases; Chapter 18. Induction of NQO1 in Cancer Cells; Section III: Quinone Reductases: Chemoprevention and Nutrition
- Chapter 19. Role of Nicotinamide Quinone Oxidoreductase 1 (NQO1) in Protection Against Toxicity of Electrophiles and Reactive Oxygen IntermediatesChapter 20. Activation and Detoxification of Naphthoquinones by NAD(P)H:Quinone Oxidoreductase; Chapter 21. Induction of Quinone Reductase as a Primary Screen for Natural Product Anticarcinogens; Chapter 22. Chemoprevention by 1,2-Dithiole-3-Thiones Through Induction of NQO1 and Other Phase 2 Enzymes; Chapter 23. Chemical Structures of Inducers of Nicotinamide Quinone Oxidoreductase 1 (NQO1)
- Chapter 24. Induction of Phase II Enzymes by Aliphatic Sulfides Derived from Garlic and Onions: An OverviewChapter 25. Upregulation of Quinone Reductase by Glucosinolate Hydrolysis Products from Dietary Broccoli; Section IV: Quinones and Age-Related Diseases; Chapter 26. Therapeutic Effects of Coenzyme Q10 in Neurodegenerative Diseases; Chapter 27. Neuroprotective Actions of Coenzyme Q10 in Parkinson's Disease; Author Index; Subject Index
- Notes:
- Description based upon print version of record.
- Includes bibliographical references and indexes.
- ISBN:
- 9786611011499
- 9781281011497
- 1281011495
- 9780080497204
- 0080497209
- OCLC:
- 808616237
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