Combinatorial chemistry. Part B / edited by Guillermo A. Morales, Barry A. Bunin.

Format:

Book

Contributor:

Morales, Guillermo A.

Bunin, Barry A.

Series:

Methods in enzymology ; v. 369.

Methods in enzymology, 0076-6879 ; v. 369

Language:

English

Subjects (All):

Combinatorial chemistry.

Organic compounds--Synthesis.

Organic compounds.

Physical Description:

1 online resource (607 p.)

Place of Publication:

Boston ; Amsterdam : Elsevier Academic Press, c2003.

Language Note:

English

Summary:

Combinatorial Chemistry encompasses both the design of compounds for specific pharmacological use and the screening of molecules in high throughput automated tests to find active agents with specific functions.*Analytical techniques*Direct sorting split and pool combinatorial synthesis*Linkers and their applications*Microwave assisted synthesis*Oligosaccharide chemistry*Peptide Synthesis and Screening*Polymer assisted approaches*Small molecule and heterocycle synthesis

Contents:

Cover; Table of Contents; Contributors to Volume 369; Preface; Volumes in Series; Section I: Analytical Techniques; Chapter 1. High-Throughput Parallel LC/UV/MS Analysis of Combinatorial Libraries; Chapter 2. Qualitative Colorimetric Tests for Solid Phase Synthesis; Section II: Directed Sorting Split-and-Pool Combinatorial Synthesis; Chapter 3. A Review of Solid-Phase Organic Synthesis on SynPhase' Lanterns and SynPhase' Crowns; Chapter 4. Directed Sorting Approach for the Synthesis of Large Combinatorial Libraries of Discrete Compounds

Chapter 5. Split-Mix Synthesis Using Macroscopic Solid Support UnitsChapter 6. The Encore Technique: A Novel Approach to Directed Split-and-Pool Combinatorial Synthesis; Section III: Linkers and Their Applications; Chapter 7. Multifunctional Linkers as an Efficient Tool for the Synthesis of Diverse Small Molecule Libraries: The Triazene Anchors; Chapter 8. The Development and Application of Tetrafluorophenol-Activated Resins for Rapid Amine Derivatization; Chapter 9. The Traceless Solid-Phase Synthesis of Organic Molecules

Chapter 10. Unnatural Diamino Acid Derivatives as Scaffolds for Creating Diversity and as Linkers for Simplifying Screening in Chemical LibrariesSection IV: Microwave-Assisted Synthesis; Chapter 11. Building Dihydropyrimidine Libraries via Microwave-Assisted Biginelli Multicomponent Reactions; Chapter 12. Microwave-Assisted Solid-Phase Organic Synthesis (MA-SPOS) of Oxazolidinone Antimicrobials; Section V: Oligosaccharide Chemistry; Chapter 13. Automated Synthesis of Polysaccharides; Chapter 14. Solid-Phase Oligosaccharide Chemistry and Its Application to Library Synthesis

Section VI: Peptide Synthesis and ScreeningChapter 15. Design, Synthesis, Screening, and Decoding of Encoded One-Bead One-Compound Peptidomimetic and Small Molecule Combinatorial Libraries; Chapter 16. Intelligent Design in Combinatorial Chemistry: Use of Designed Peptide Libraries to Explore Secondary and Tertiary Structures in Peptides and Proteins; Chapter 17. Synthesis and Screening of ''One-Bead One- Compound'' Combinatorial Peptide Libraries; Chapter 18. Synthetic Combinatorial Libraries as an Alternative Strategy for the Development of Novel Treatments for Infectious Diseases

Section VII: Polymer-Assisted ApproachesChapter 19. Advances in the Applications of Polymer- Supported Reagents for Organic Synthesis; Chapter 20. Advanced Polymer Reagents Based on Activated Reactants and Reactive Intermediates: Powerful Novel Tools in Diversity-Oriented Synthesis; Chapter 21. Scavenger Resins in Solution-Phase CombiChem; Section VIII: Small Molecule and Heterocycle Synthesis; Chapter 22. Cyclative Cleavage Strategies for the Solid- Phase Synthesis of Heterocycles and Natural Products

Chapter 23. Derivatization Reactions of Heterocyclic Scaffolds on Solid Phase: Tools for the Synthesis of Drug-Like Molecule Libraries

Notes:

Description based upon print version of record.

Includes bibliographical references and indexes.

ISBN:

9786611011390

9781281011398

1281011398

9780080497105

0080497101

OCLC:

476068118