Fast liquid chromatography-mass spectrometry methods in food and environmental analysis / editors, Oscar Núñez [and three others].

Format:

Book

Contributor:

Núñez Burcio, Oscar, editor.

Language:

English

Subjects (All):

High performance liquid chromatography.

Mass spectrometry.

Food--Analysis.

Food.

Environmental protection.

Physical Description:

1 online resource (625 p.)

Distribution:

Singapore ; Hackensack, New Jersey ; London, [England] : World Scientific Publishing Co. Pte. Ltd., [date of distribution not identified]

Place of Publication:

London, [England] : Imperial College Press, 2015.

Language Note:

English

Summary:

There is a growing need for high-throughput separations in food and environmental research that are able to cope with the analysis of a large number of compounds in very complex matrices. Whereas the most common approach for solving many analytical problems has often been high-performance liquid chromatography (HPLC), the recent use of fast or ultra-fast chromatographic methods for environmental and food analysis has increased the overall sample throughput and laboratory efficiency without loss (and even with an improvement) in the resolution obtained by conventional HPLC systems. This book brings together researchers at the top of their field from across the world to discuss and analyze recent advances in fast liquid chromatography–mass spectrometry (LC-MS) methods in food and environmental analysis. First, the most novel approaches to achieve fast and ultra-fast methods as well as the use of alternative and complementary stationary phases are described. Then, recent advances in fast LC–MS methods are addressed, focusing on novel treatment procedures coupled with LC–MS, new ionization sources, high-resolution mass spectrometry, and the problematic confirmation and quantification aspects in mass spectrometry. Finally, relevant LC–MS applications in food and environmental analysis such as the analysis of pesticides, mycotoxins, food packaging contaminants, perfluorinated compounds and polyphenolic compounds are described. The scope of the book is intentionally broad and is aimed at worldwide analytical laboratories working in food and environmental applications as well as researchers in universities worldwide.

Contents:

Contents; Preface; Part 1 Fast Liquid Chromatography Advances; Chapter 1. UHPLC Separations Using Sub-2 μm Particle Size Columns; 1.1. General Introduction to Ultrahigh Performance Liquid Chromatography (UHPLC); 1.2. Proof-of-Concept of Ultrahigh-Pressure Liquid Chromatography (UHPLC) During the 1990s; 1.3. Benefits of UHPLC Technique: Speed, Resolution, Solvent Consumption and Sensitivity; 1.4. Method Transfer between HPLC and UHPLC; 1.4.1. Rules and examples in the isocratic mode; 1.4.2. Rules and examples in the gradient mode; 1.5. The Importance of Instrumentation in UHPLC

1.5.1. Extra-column band broadening1.5.2. System dwell volume; 1.5.3. System upper pressure limit; 1.5.4. Detector data acquisition rate for UHPLC operation; 1.5.5. Overview of UHPLC instruments and columns on the market; 1.6. The Importance of Frictional Heating under Very High Pressure Conditions; 1.7. Comparison of UHPLC Performance with Other Modern LC Strategies; 1.8. Conclusions and Perspectives; References; Chapter 2. Core-Shell Column Technology in Fast Liquid Chromatography; 2.1. Introduction; 2.2. Fused-Core Technology: Benefits and New Possibilities

2.3. Overview of Columns on the Market2.4. Core-Shell Column Technology in Food and Environmental Analysis; 2.5. Concluding Remarks; References; Chapter 3. Monolithic Columns in Fast Liquid Chromatography; 3.1. Features of Monolithic Silica Columns: Rapid Separation Using Monolithic Silica Columns in Rod and Capillary Formats; 3.1.1. Fabrication of columns; 3.1.2. The support structure regarding through-pores, skeletons, and amount of silica in a column; 3.1.3. Column permeability, column efficiency, and improvement of preparation method; 3.1.3.2. Second-generation monolithic silica columns

3.1.4. Current performance of monolithic silica columns3.1.5. Kinetic performance; 3.1.6. Functionalization of monolithic silica columns; 3.1.7. Advantages and disadvantages: roles of monolithic silica columns; 3.1.7.1. Advantages associated with monolithic silica columns; 3.1.7.2. Disadvantages associated with monolithic silica columns; 3.1.7.3. Role of monolithic silica columns; 3.2. Features of Organic Polymer Monolithic Columns; 3.3. Food and Environmental Applications; 3.4. Summary and Conclusions; References; Chapter 4. High-Temperature Liquid Chromatography

4.1. A Brief Definition of High-Temperature Liquid Chromatography4.1.1. Using high eluent temperatures for increasing the separation speed; 4.1.2. Using high eluent temperatures for modulation of solvent strength; 4.2. Instrumental Requirements; 4.3. Suitable Stationary Phases; 4.3.1. Silica-based stationary phases; 4.3.2. Porous graphitic carbon; 4.3.3. Metal oxide stationary phases; 4.3.4. Polymeric stationary phases; 4.4. Retention Time Modeling; 4.4.1. Van't Hoff equation; 4.4.2. Isothermal separations; 4.4.3. Temperature programmed separations; 4.4.4. Multi-gradient separations

4.5. Special Hyphenation Techniques

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters and index.

Description based on print version record.

ISBN:

1-68015-861-9

1-78326-494-2

OCLC:

903675868