Bioprocess engineering : an introductory engineering and life science approach / Kim Gail Clarke.

Format:

Book

Author/Creator:

Clarke, Kim Gail.

Series:

Gale eBooks

Language:

English

Subjects (All):

Biochemical engineering.

Physical Description:

1 online resource (xix, 245 pages) : illustrations

Edition:

1st edition

Place of Publication:

Cambridge : Woodhead Publishing, 2013.

Language Note:

English

System Details:

text file

Summary:

Biotechnology is an expansive field incorporating expertise in both the life science and engineering disciplines. In biotechnology, the scientist is concerned with developing the most favourable biocatalysts, while the engineer is directed towards process performance, defining conditions and strategies that will maximize the production potential of the biocatalyst. Increasingly, the synergistic effect of the contributions of engineering and life sciences is recognised as key to the translation of new bioproducts from the laboratory bench to commercial bioprocess. Fundamental to the successful

Contents:

Cover; Bioprocess engineering: An introductory engineering and life science approach; Copyright; Dedication; Contents; List of figures; List of plates; Preface; About the author; 1Historical development: from ethanol to biopharmeceuticals; 1.1 Notes; 2Microbiology; 2.1 Microorganisms: the core of cellular bioprocesses; 2.2 Cellular structure and sites of metabolic reactions; 2.3 Classification according to carbon and energy requirements; 2.4 Nutrient requirements; 2.5 Notes; 3Metabolic macromolecules; 3.1 Carbohydrates; 3.2 Lipids; 3.3 Proteins; 3.4 Nucleosides, nucleotides and nucleic acids

3.5 Notes4Molecular biology; 4.1 Replication, transcription and translation; 4.2 Genetic regulation; 4.3 Genetic modification; 4.4 Notes; 5Carbon metabolism; 5.1 Energy generation, storage and transfer; 5.2 Catabolic pathways: energy generation; 5.3 Anabolic pathways: energy utilisation; 5.4 Notes; 6Enzymes as biocatalysts; 6.1 Enzyme kinetics with no inhibition; 6.2 Enzyme kinetics with inhibition; 6.3 Enzyme reactors with soluble enzymes; 6.4 Enzyme reactors with immobilised enzymes; 6.5 Notes; 7 Microbial kinetics during batch, continuous and fed-batch processes; 7.1 The nutrient medium

7.2 Batch process design equations7.3 Continuous process design equations; 7.4 Fed-batch bioprocess design equations; 7.5 Notes; 8 The oxygen transfer rate and overall volumetric oxygen transfer coefficient; 8.1 Oxygen transfer design equations; 8.2 Measurement of the oxygen transfer rate; 8.3 Notes; 9Bioprocess scale up; 9.1 Scale up with constant oxygen transfer rate; 9.2 Scale up with constant mixing; 9.3 Scale up with constant shear stress; 9.4 Scale up with constant flow regime; 9.5 Notes; 10Bioprocess asepsis and sterility; 10.1 Heat sterilisation of media and equipment

10.2 Filter sterilisation of air10.3 Notes; 11Downstream processing; 11.1 Overview of potential recovery operations; 11.2 Separation of cells and extracellular fluid; 11.3 Cell rupture and separation of cell extract; 11.4 Concentration and purification of soluble products; 11.5 Notes; Index

Notes:

Includes bibliographical references and index.

Description based on print version record.

Includes index.

ISBN:

9781628703696

1628703695

9781782421689

1782421688

OCLC:

864361336