Handbook of pharmaceutical analysis by HPLC / edited by Satinder Ahuja, Michael W. Dong.

Format:

Book

Contributor:

Ahuja, Satinder, 1933-

Dong, M. W.

Series:

Separation science and technology (San Diego, Calif.) ; v. 6.

Separation science and technology ; v. 6

Language:

English

Subjects (All):

High performance liquid chromatography--Handbooks, manuals, etc.

High performance liquid chromatography.

Drugs--Analysis.

Drugs.

Physical Description:

1 online resource (679 pages)

Edition:

1st ed.

Other Title:

Pharmaceutical analysis by HPLC

Place of Publication:

Amsterdam ; San Diago : Elsevier Academic Press, 2005.

Language Note:

English

Summary:

High pressure liquid chromatography-frequently called high performance liquid chromatography (HPLC or, LC) is the premier analytical technique in pharmaceutical analysis and is predominantly used in the pharmaceutical industry. Written by selected experts in their respective fields, the Handbook of Pharmaceutical Analysis by HPLC Volume 6, provides a complete yet concise reference guide for utilizing the versatility of HPLC in drug development and quality control. Highlighting novel approaches in HPLC and the latest developments in hyphenated techniques, the book captures the essence of

Contents:

Front Cover; Handbook of Pharmaceutical Analysis by HPLC; Copyright Page; Contents; Preface; Contributors; Chapter 1. Overview: Handbook of Pharmaceutical Analysis by HPLC; I. Introduction; II. Key Concepts in HPLC; III. HPLC Instrumentation in Pharmaceutical Analysis; IV. HPLC Columns in Pharmaceutical Analysis; V. Sample Preparation; VI. Method Development; VII. Method Validation; VIII. Ion Chromatography; IX. How to be More Successful with HPLC Analysis; X. Regulatory Practices; XI. HPLC System Calibration; XII. System Validation; XIII. Assay and Stability Testing

XIV. Impurity Evaluations; XV. Dissolution Testing; XVI. Cleaning Validation; XVII. High-throughput Screening; XVIII. Chiral Separations; XIX. LC-MS; XX. LC-NMR; XXI. Chromatography Data Processing; XXII. New Developments in HPLC; References; Chapter 2. Key Concepts of HPLC in Pharmaceutical Analysis; Abstract; I. Introduction; II. Fundamental Concepts; Ill. Mobile Phase Parameters; IV. Isocratic Vs. Gradient Analysis; V. Limit of Quantitation; VI. Glossary of HPLC Terms; VII. Summary and Conclusion; Acknowledgments; References

Chapter 3. HPLC Instrumentation in Pharmaceutical Analysis: Status, Advances, and Trends; Abstract; I. Introduction; II. HPLC Solvent Delivery Systems; III. Manual Injectors; IV. Autosamplers; V. Detectors; VI. UV/VIS Absorbance Detectors; VII. Photodiode Array (PDA) Detectors; VIII. Other Detectors; IX. Data Handling; X. Instrumental Bandwidth (IBW); XI. Instrumentation Trends in Pharmaceutical Analysis; XII. Manufacturers; XIII. Summary and Conclusion; Acknowledgments; References; Chapter 4. HPLC Columns for Pharmaceutical Analysis; Abstract; I. Introduction; II. Column Physics

III. Column Chemistry; IV. Summary; References; Chapter 5. Sample Preparation for HPLC Analysis of Drug Products; Abstract; I. Introduction; II. Sample Preparation Overview; III. Primary SP Concerns for Types of Analysis; IV. Sample Preparation Trends in Pharmaceutical Analysis; V. Case Studies; VI. Summary and Conclusion; Acknowledgments; References; Chapter 6. HPLC Method Development; Abstract; I. Introduction; II. Phase-Appropriate Method Development; III. Proactive Method Development; IV. Development, Validation, and Use of Early Phase Methods; V. Final Method Development and Validation

VI. Conclusions; Acknowledgments; References; Chapter 7. Validation of HPLC Methods in Pharmaceutical Analysis; Abstract; I. Introduction; II. Validation Requirements for Method Type; III. Procedures and Protocols; IV. Validation Parameters; V. Method Validation by Phase of Development; VI. Reference Standards; VII. Method Transfer; VIII. Documentation; IX. Method Revalidation; X. Method-Validation Software; XI. Summary; Acknowledgments; References; Chapter 8. Ion Chromatography; Abstract; I. Introduction; II. Ion Chromatography Instrumentation; III. Chromatographic Components; IV. Pharmaceutical Ion Chromatography Applications

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-280-63057-4

9786610630578

0-08-045518-2

OCLC:

476000053