Advances in medicine and biology Volume 14 / Leon V. Berhardt, editor.

Format:

Book

Contributor:

Berhardt, Leon V.

Series:

Advances in Medicine and Biology.

Advances in biology and medicine ; vol. 14

Language:

English

Subjects (All):

Medicine.

Biology.

Physical Description:

1 online resource (267 p.)

Edition:

1st ed.

Place of Publication:

New York : Nova Science Publishers, c2011.

Language Note:

English

Summary:

This study focuses on the symptoms, diagnosis and treatment of Pompe disease; insulin resistance and its relation to intra-uterine growth retardation; evidence-based medicine research; and the therapeutic values of Vitamin E supplements.

Contents:

Intro

ADVANCES IN MEDICINE AND BIOLOGY. VOLUME 14

Contents

Preface

Chapter I Methods of Study of Energy Expenditure

Abstract

Introduction

Importance of the Study of the Energy Metabolism

Energy Expenditure and its Components

The Effect of Nutritional Situation in Energy Metabolism

The Effect of Illness in Energy Metabolism

Methods of Study of Energy Expediture

Methods of Estimation of Energy Expenditure

Methods of Estimation of Physical Activity

Indirect Calorimetry

Direct Calorimetry

Doubly-Labeled Water Method

Energy Balance Studies

Movement Sensors

Heart Rate Monitoring

Core Body Temperature

Heat Flow Measurement

Combined Methods

References

Chapter II Pompe Disease: Symptoms, Diagnosis and Treatment

Clinical Presentation

Infantile onset of Disease

Childhood or Juvenile or Adult form of Disease (Late onset or Non Classic form of the Disease)

Diagnosis

Blood Chemistry Study

Electromyography and Electrocardiography

Muscle Biopsy

Measurement of Enzyme Activity (Alpha-1,4-Glucosidase)

Mutation Study

Prenatal Diagnosis

Therapeutic Approaches

Effect of ERT in Infantile Pompe Disease

Effect of ERT in Late onset Pompe Disease

Safety and Limitations of ERT

Future Perspectives and Experimental Therapies

Conclusion

Acknowledgments

Chapter III Review Insulin Resistance: Intra-Uterine Growth Retardation, Life Style, Genetic Susceptibility, Prevention and Treatment

Metabolic Syndrome

1. Intra-Uterine: Growth Retardation, Epigenesis

Reduced Fetal Growth and Low Birth Weight

2. Life Style: Obesity, Sexe Differences, Race, Physical Activity and Psychosocial Stress.

Overweight among Racial/Ethnic Groups, Differences between Races

3. Genetic Susceptibility: "Thrifty Genes and Inflammation

Key Players in Insulin Resistance: PPAR-Gamma

Resistin

4. Prevention and Treatment

Chapter IV Microbial Diversity of Biofilm Technologies used for Water Treatment

Microbial Diversity Methodology

Microbial Community Profiling Methods

Culture Dependent Techniques

Culture Independent Techniques

Functional Diversity within Microbial Communities

Microbial Structure Visualization

Biofilm Diversity in Submerged Biofilter Technologies for Water Treatment

Nitrogen Based Compounds and Wastewaters

Archaea in Industrial and Domestic Wastewaters

Nitrate Removal from Groundwater

Heavy Metal Containing Waters

Current Problems and Future Trends in Microbial Population Assessment

Chapter V Applying Project Management to Evidence-Based Medicine Research

Medical Research

Project Management Applied to EBM

Discussion

Chapter VI Genetic Counseling for Pompe Disease

Confirming a Diagnosis

Testing

Interpretation of Results

Education and Psychosocial Counseling for Pompe Disease

Treatment and Management Options

Administration of Enzyme Replacement Therapy

Assessing Disease Progression

Standard of Care and Multisystem Evaluation

Referring to Ancillary Specialties

Managing Disease Progression and Follow up

Assistive Therapies, Aids and Devices

Pediatric to Adult Transition

Reviewed by

Supported by

Chapter VII Therapeutic Values of Vitamin E Supplements in Clinical Practices

Background

Chemistry

Vitamin E Supplement

Clinical Indications.

Other Applications

Clinical Pharmacology

Dosage

Metabolism and Mechanisms

Clinical Trials

Chapter VIII The Influence of the Nutrient Load on the Formation of Escherichia Coli Biofilms

1. Introduction

1.1 Biofilm Formation Process

1.2 Microbial Biofilms in Food Industry

1.3 Nutrient-Load Effect on Biofilm

2. Experiental Set-up

2.1 Biofilm System and Sampling

2.2 Bacterial Growth and Culture Conditions

2.3 Analytical Methods

3. Results and Discussion

Chapter IX Physiology and Pathophysiology of Megalin-Mediated Endocytosis in Renal Proximal Tubule Cells

Megalin, a Major Endocytic Receptor in PTC

Molecules Associated with Megalin's Functions in PTC

Regulation of Megalin Expression

Intracellular Adaptor Proteins and Motors that Interact with Megalin

Handling of Albumin in PTC, Related to Mechanisms of Albuminuria

Overloaded Endocytosis-Induced PTC Injury

Megalin-Mediated Signal Transduction

Clinical Application of Detection of Megalin Shed in Urine

Chapter X In Vitro Expanded CD8+ NKT-Like Cells Possess Potent Cytotoxic and Immunosuppressive Activities

Abbreviations

Materials and Methods

Mice

In Vitro Culture of CD8+ and CD4+ T Cells

In Vitro Suppression Assays

Flow Cytometry

RT-PCR Analysis

Cytotoxicity Assay

Results

Phenotypes of CD8+ NKT-Like Cells

CD8+ NKT-Like Cells Suppress Proliferation of Both CD4+ and CD8+ T Cells

In Vitro Cultured CD8+ NKT-Like Cells Possess Potent Cytotoxic Activity

The Suppression Activity of CD8+ NKT-Like Cells Involves Direct Interaction with Naïve T Cells

Suppression Function of CD8+ NKT-Like Cells Requires Proper Activation.

Suppressive Activity of CD8+ NKT-Like Cells is Mostly Cell Contact-Dependent

CD8+ NKT-Like Cells Inhibit Activation and Il-2 Production of Responder T Cells

Acknowledgment

Chapter XI Severe Late Onset Pompe Disease: Management and Treatments

Epidemiology and Clinical Presentation of Late onset Forms

Clinical Presentation and Prevalence of Patients with Severe Motor Deficit

Muscular Assessment in LOPD

Proposed Motor and Functional Evaluation in LOPD

Respiratory Management

Respiratory and Sleep Exploration

Respiratory Exploration

Sleep Exploration

Prevalence of Patients Needing Invasive or Non-Invasive Ventilation

Criteria for Starting Ventilation

Relationship between Respiratory Impairment and Muscular Impairment (Figures 1 And 2)

Effect of Enzymotherapy

Chapter XII Biofilm Development Kinetics

2. Growth Kinetics of Microorganisms and Biofilm

3. Population of Microorganisms

4. Structure of Biofilm

5. Case Studies

5.1 Mean Density of Microorganisms

5.2 Maximum Thickness of Biofilms

5.3 Development of Biofilm

Appendix A: Integral of Equation (7)

Appendix B: Properties of Coefficient P

Chapter XIII Definition of Empirical Physical Parameter of Food Texture for Infants and that for Dysphagic Patients and People Having Difficulty in Swallowing Using Official Puncture Tests in Japan

Materials

1) 1% apple pectin solution

2) Pumpkin paste

Methods

Results and Discussion

1. Ft-L curve

2. Contributions of Ft at the curved and base surfaces to the total of Ft on the plunger

Nomenclature

Index.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-61122-285-0

OCLC:

923669296