The functions, disease-related dysfunctions, and therapeutic targeting of neuronal mitochondria / edited by Valentin K. Gribkoff, Elizabeth A. Jonas, J. Marie Hardwick ; contributors, Kambiz N. Alavian [and forty six others].

Format:

Book

Contributor:

Gribkoff, Valentin K., editor.

Jonas, Elizabeth A., editor.

Hardwick, J. Marie, editor.

Alavian, Kambiz N., contributor.

Series:

Wiley Series on Neuropharmacology

Language:

English

Subjects (All):

Mitochondrial pathology.

Mitochondria--Formation.

Mitochondria.

Nervous system--Diseases--Treatment.

Nervous system.

Physical Description:

1 online resource (526 p.)

Edition:

1st ed.

Place of Publication:

[Place of publication not identified] : Wiley, 2015.

Language Note:

English

Summary:

This book presents advances in the field of neuronal mitochondria - functions, relation to therapeutics, and pharmacology. For scientists and researchers in both industry and academia, this book provides detailed discussion, examples, and approaches, to illustrate the potential of mitochondria as therapeutic targets for neuronal diseases. • Helps readers understand the regulation of mitochondrial cellular processes, such as substrate metabolism, energy production, and programmed versus sporadic cell death • Offers insights on the development of strategies for targeted therapeutic approaches and potential personalized treatments • Includes examples of mitochondrial drugs, development, and mitochondria-targeted approaches for more efficient treatment methods and further developments in the field • Covers the model systems and approaches needed for the development of new drugs for the central nervous system to provide potential modern therapeutics for neurodegenerative disorders

Contents:

Mitochondrial permeability transition : look from a different angle / N. Brustovetsky

The mitochondrial permeability transition pore, the c-subunit of the F1Fo ATP synthase, cellular development and synaptic efficiency / E.A. Jonas, G.A. Porter, Jr., G. Beutner, N. Mnatsakanyan and K.A. Alavian

Mitochondrial channels in neurodegeneration / P.M. Peixoto, K.W. Kinnally and Evgeny Pavlov

Mitochondrial Ca2+ transport in the control of neuronal functions : molecular and cellular mechanisms / Y.M. Usachev

AMP-activated protein kinase (AMPK) as a cellular energy sensor and therapeutic target for neuroprotection / P. Weisova, S. Pfeiffer and J.H.M. Prehn

HDAC6 : a molecule with multiple functions in neurodegenerative diseases / Y. Yan and R. Jiao

Neuronal mitochondrial transport / A.L. Knight, Y. Chen, T. Sun and Z.-H. Sheng

Mitochondria in control of hypothalamic metabolic circuits / C.M. Nasrallah and T.L. Horvath

Mitochondria anchored at the synapse / G.A. Spirou, D. Jackson and G.A. Perkins

Neuronal mitochondria are different : relevance to neurodegenerative disease / S.B. Berman and J.M. Hardwick

PINK1 as a sensor for mitochondrial function : dual roles / E.K. Steer, M.K. Dail and C.T. Chu

A get-together to tear it apart : the mitochondrion meets the cellular turnover machinery / G.-L. McLelland and E.A. Fon

Mitochondrial involvement in neurodegenerative dementia / L. Bonanni, V. Frazzini, A. Thomas and M. Onofrj

Neuronal mitochondria as a target for the discovery and development of new therapeutics / V.K. Gribkoff

Mitochondria as a therapeutic target for Alzheimer's disease / C.H.-L. Hung, S.S.-Y. Chung, S.M.-Y. Lee and R.C.-C. Chang

Mitochondria in Parkinson disease / G. Arena and E.M. Valente

Therapeutic targeting of neuronal mitochondria in brain injury / H.M. Yonutas, E.D. Hall and P.G. Sullivan

The use of fibroblasts from patients with inherited mitochondrial disorders for pathomechanistic studies and evaluation of therapies / D. Soiferman and A. Saada.

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters and index.

Description based on print version record.

ISBN:

9781119017103

1119017106

9781119017127

1119017122

9781119016724

111901672X

OCLC:

911200069