Septic shock : symptoms, management and risk factors / Melvin C. Johnston and Jerome E. Knight, editors.

Format:

Book

Contributor:

Johnston, Melvin C.

Knight, Jerome E.

Series:

Emergency and Intensive Care Medicine

Emergency and intensive care medicine

Language:

English

Subjects (All):

Septic shock.

Physical Description:

1 online resource (177 p.)

Edition:

1st ed.

Place of Publication:

New York : Nova Science Publishers, Inc., 2012.

Language Note:

English

Summary:

Septic shock is a common and lethal condition that remains one of the leading causes of death in the hospital. Greater awareness, understanding of the condition and knowledge of effective management may decrease the mortality rate. In this book, the authors discuss the symptoms, management and risk factors of septic shock.

Contents:

Intro

SEPTIC SHOCK: SYMPTOMS, MANAGEMENT AND RISK FACTORS

Library of Congress Cataloging-in-Publication Data

Contents

Preface

Chapter 1: Pathophysiology of Cardiovascular Failure in Septic Shock

Abstract

Introduction

1. Molecular Mechanisms in the Pathophysiology of Septic Shock

1.1. Changes of Myocyte ion Transport by Inflammatory Mediators

Calcium Channels

Potassium Channels

1.3. Changes in Cytoskeletal Proteins

1.3. Mitochondrial Dysfunction in Septic Shock

1.4. The Role of Endotoxins and Bacterial Virulence Factors in Septic Shock

Endotoxin

Effects of other Bacterial Toxins

2. Microcirculation in Septic Shock

3. Myocardial Dysfunction in Septic Shock

3.1. The role of Cytokines in Myocardial Dysfunction

3.2. Myocardial Cell Death

3.2.1. The Role of Poly(Adenosine 5'-diphosphate-ribose)

Polymerase Activation

3.2.2. The Role of Nitric Oxide

4. Pathophysiology of Inotrope Refractory Cardiovascular Failure

Conclusion

References

Chapter 2: Sepsis and Septic Shock: Risk Factors, Symptoms and Management

Risk Factors

Definitions

Pathogenesis

Symptoms

Management

Early Management

Ongoing Management

Recommendations

Chapter 3: Septic Shock: Clinical Diagnosis and Risk Factors

Abbreviations

1. Introduction

1.1. Basic Concepts

1.2. Epidemiological Impact of Sepsis and Septic Shock

2. Clinical Approach to the Septic Patient

2.1. Suspected Sepsis in the ER

2.2. Patients at Risk of Septic Shock

2.3. Confirming the Diagnosis

2.3.1. Laboratory Analyses and Work-Up

2.3.2. Imaging Studies

2.3.3. New Diagnostic Tools and Future Research

2.3.3.1. Inflammatory Biomarkers

2.3.3.2. Oxidative Stress Biomarkers.

Conclusion

Chapter 4: Diagnosis and Management of Life-Threatening Infections and Septic Shock During Idiopathic Drug-Induced Agranulocytosis

Criteria for the Definition of Idiopathic Drug-Induced Agranulocytosis

Epidemiology of Agranulocytosis

Incriminated Drugs in Idiopathic Agranulocytosis

Clinical Manifestations of Drug-Induced Neutropenia and Agranulocytosis

Differential Diagnosis of Acute Neutropenia

Prognosis and Mortality Rate of Drug Induced Agranulocytosis, Frailty Patients

Management of Drug-Induced Severe Neutropenia or Agranulocytosis

Prevention

General Measures

Indications of Antimicrobial Agents

Indications of Hematopoietic Growth Factors

Chapter 5: Sepsis: A Disease of the Microcirculation

Microcirculation

The Shunting Theory of Sepsis

Monitoring the Microcirculation

Nailfold videocapillaroscopy

Laser Doppler

Orthogonal Polarization Spectral

and Sidestream Dark Field Imaging

Near-Infrared Spectroscopy

The Microcirculation in Sepsis

Sepsis and Outcome

Vasopressors and Inotropes

Norepinephrine

Dobutamine

Levosimendan

Vasodilators

Red Blood Cell Transfusion

Fluids

Steroids

Sedatives

Chapter 6: The Role of HMGB1 in Cardiac Dysfunction During Septic Shock

Mechanism of Sepsis-Related

Cardiac Dysfunction

The Role of HMGB1 in Sepsis

and as a Potential Therapeutic Target

Chapter 7: Pathophysiology of Sepsis and Septic Shock

2. Introduction

3. Pathophysiology of Sepsis

3.1. Basic Molecular Mechanisms of Inflammation in Sepsis

3.1.1. Pathogen-Host Interaction

3.1.2. Neutrophils

3.1.3. Cytokines.

3.1.4. Coagulation Disorders in Sepsis

3.1.5. Endothelial Cells

3.1.6. Complement Activation

3.2. Immunoparalysis

4. Pathophysiology of Septic Shock

Conclusion and Future Goals

Index.

Notes:

"Nova biomedical."

Includes bibliographical references and index.

ISBN:

1-62257-499-0

OCLC:

846979612