Type I collagen : biological functions, synthesis and medicinal applications / Maria Eduarda Henriques and Marcio Pinto, editors.

Format:

Book

Contributor:

Henriques, Maria Eduarda.

Pinto, Marcio.

Series:

Biomaterials--properties, production, and devices series.

Biomaterials--properties, production and devices

Stem cells and regenerative medicine

Language:

English

Subjects (All):

Collagen.

Physical Description:

1 online resource (200 p.)

Edition:

1st ed.

Place of Publication:

New York : Nova Science Publishers, Inc., 2012.

Language Note:

English

Summary:

Type I collagen is a popular biomaterial for use in tissue engineering and regenerative medicine applications owing to its abundance in natural tissues and its natural functions within the body as a scaffold material with favorable cell- interactive properties. In this book, the authors present current research in the study of the biological functions, synthesis and medicinal applications of Type I collagen. Topics discussed include collagen type I as a candidate for in vivo delivery systems for cells, proteins, and drugs; degradation of type I collagen and the pathogenesis of infectious diseases; Type I collagen's synthesis, biological functions and medical applications during systemic inflammation; using collagen-based scaffolds in tissue engineering and repair; type I collagens from marine sources; and the role of extracellular matrix in the wound repair process.

Contents:

Intro

TYPE I COLLAGEN: BIOLOGICAL FUNCTIONS, SYNTHESIS AND MEDICINAL APPLICATIONS

Library of Congress Cataloging-in-Publication Data

CONTENTS

PREFACE

Chapter I: COLLAGEN TYPE I: A PROMISING SCAFFOLD MATERIAL FOR TISSUE ENGINEERING AND REGENERATIVE MEDICINE

ABSTRACT

INTRODUCTION

COLLAGENS AS RAW MATERIALS

Extracted Collagens

Collagen Biosynthesis

Recombinantly Produced Collagen

COLLAGEN AS A BIOMATERIAL

COLLAGEN CROSSLINKING

TISSUE ENGINEERING APPLICATIONS

Hemostasis

Bone

Cartilage

Cornea

Cardiovascular

Nerve Tissue

Therapeutic Agents Delivery

CONCLUSION

REFERENCES

Chapter II: DEGRADATION OF TYPE I COLLAGEN AND PATHOGENESIS OF INFECTIOUS DISEASES

METALLOPROTEASE COLLAGENASES

Matrix Metalloproteases

M9 Bacterial Collagenases

NON-METALLOPROTEASE COLLAGENASES

Serine Proteases

Cysteine Proteases

HUMAN PATHOGENS VERSUS COLLAGEN DEGRADATION

Chapter III: TYPE I COLLAGEN AND ITS UTILITYAS SPECIFIC BONE MARKER

BACKGROUND

TYPE I COLLAGEN

Clinical Use of C- and N-Propeptides

AGEING MOLECULAR CHANGES IN THE STRUCTURAL COMPONENTS TYPE I COLLAGEN

1. Lysyl Oxidase-Derived Cross-Links

2. Non-Enzymic Glycosylation-Derived Cross-Links (Glycation)

COLLAGEN BREAKDOWN

Chapter IV: DEVELOPMENT OF 3-D COLLAGEN GEL VASCULARIZED TISSUE-ENGINEERED CONSTRUCTS FOR BONE REPLACEMENT AND REGENERATION USING EMBRYONIC AND POSTNATAL PROGENITORS

1. INTRODUCTION

2. SIGNIFICANCE AND ROLE OF ECM MATERIALS DURING TISSUE REGENERATION AND DEVELOPMENT

3. EXPERIMENTAL APPROACH

4. RESEARCH METHODS

4.1. Fabrication of Tubular Scaffold.

4.2. BMSCs isolation, Expansion and Maintenance (Nonclonal BMSC Culture)

4.3. Immunophenotyping of BMSCs by Flow Cytometry and Confocal Microscopy

4.4. Purification and Enrichment of CD90+ BMSCs by Magnetic-activated Cell Sorting (MACS)

4.5. BMSCs Osteoblastic Differentiation

4.6. Quail PE Isolation and BMSCs/PEs Co-culture

5. BMSCS AND BMSCS/PES BASED VASCULARIED BONE REGENERATION

ACKNOWLEDGMENTS

Chapter V: COLLAGEN I SYNTHESIS, BIOLOGICAL FUNCTIONS AND MEDICAL APPLICATIONS DURING SYSTEMIC INFLAMMATION

ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS)

RENAL FIBROSIS

HEART FIBROSIS

GASTROINTESTINAL DYSFUNCTIONS

MEDICAL APPLICATION OF TYPE I COLLAGENIN SYSTEMIC INFLAMMATION

Chapter VI: COLLAGEN SCAFFOLDS: TISSUE ENGINEERING AND REPAIR

TISSUE ENGINEERING AND CONNECTIVE TISSUE REPAIR

SCAFFOLDS FOR TISSUE ENGINEERING

COLLAGEN-BASED SCAFFOLDS FOR ORAL-MAXILLOFACIAL,BONE, CARTILAGE, SKIN, AND VASCULAR TISSUE ENGINEERING

ACKNOWLEDGMENT

Chapter VII: BIOMEDICAL IMPLICATIONS OF TYPE I COLLAGEN: A MARINE PERSPECTIVE

STRUCTURAL AND FUNCTIONAL ASPECTS OF TYPE I COLLAGEN

BIOMEDICAL APPLICATIONS OF TYPE I COLLAGEN

MARINE DERIVED TYPE I COLLAGEN AND ITS BIOMEDICAL SIGNIFICANCE

Chapter VIII: ROLE OF EXTRACELLULAR MATRIXIN THE WOUND REPAIR PROCESS

THE EXTRACELLULAR MATRIX

CELL-MATRIX INTERACTIONS

ADVANCED WOUND HEALING THERAPIES

CONCLUSIONS AND PERSPECTIVES

INDEX.

Notes:

"Nova biomedical."

Includes bibliographical references and index.

Description based on print version record.

ISBN:

1-62257-626-8

OCLC:

846980055