Natural products : structure, bioactivity and applications / Ramiro E. Goncalves and Marcos Cunha Pinto, editors.

Format:

Book

Contributor:

Goncalves, Ramiro E.

Pinto, Marcos Cunha.

Series:

Biochemistry research trends series.

Biochemistry research trend

Language:

English

Subjects (All):

Natural products.

Physical Description:

1 online resource (231 p.)

Edition:

1st ed.

Place of Publication:

New York : Nova Biomedical, c2012.

Language Note:

English

Summary:

A natural product is a chemical compound or substance produced by a living organism - found in nature that usually has a pharmacological or biological activity for use in pharmaceutical drug discovery and drug design. A natural product can be considered as such even if it can be prepared by total synthesis. In this book, the authors present current research in the study of the structure, bioactivity and applications of natural products. Topics discussed include the in-vitro assessment of chromones and alkaloids from Caribbean plants as potential anti-tuberculars and chemopreventors; natural products as inhibitors of ubiquitin and ubiquitin-like protein-proteasome pathways; the biological activities of red propolis; nanoencapsulation of natural products; and natural products as a source of potential drugs for the treatment of fungal infections.

Contents:

Intro

NATURAL PRODUCTS: STRUCTURE, BIOACTIVITY AND APPLICATIONS

Library of Congress Cataloging-in-Publication Data

CONTENTS

PREFACE

Chapter 1: PTERIDOPHYTES: ETHNOBOTANY AND PHARMACOLOGIC BIOACTIVITIES

ABSTRACT

1. INTRODUCTION

2. PTERIDOPHYTES: CHARACTERIZATION AND ECOLOGICAL ASPECTS

3. ETHNOBOTANICAL ASPECTS: SOCIO-ECONOMIC IMPORTANCE OF SECOND LARGEST GROUP OF VASCULAR PLANTS

4. ETHNOMEDICINE OF PTERIDOPHYTES: POPULAR WISDOM AND HEALTH

5. PROVING BIOACTIVITIES: ELUCIDATION OF ETHNOMEDICINE MYSTERIES

Antibacterial Activity

Antifungal Activity

Anticancer Activity

Antiviral Activity

Antiparasitic Activity

Antioxidant Activity

6. A CASE STUDY: ASSESSMENT OF ANTIOXIDANT ACTIVITY AND CHARACTERIZATION OF PHENOLIC COMPOUNDS OF LYGODIUM VENUSTUM SW. AND PITYROGRAMMACALOMELANOS (L.) LINK

Introduction

Material and Methods

RESULTS AND DISCUSSION

CONCLUSION

ACKNOWLEDGEMENTS

REFERENCES

Chapter 2: IN-VITRO ASSESSMENT OF CHROMONES, ALKALOIDS AND OTHER NATURAL PRODUCTS FROM CARIBBEAN PLANTS AS POTENTIAL ANTI-TUBERCULARS AND CHEMOPREVENTORS

INTRODUCTION

Status of Tuberculosis

Arylamine N-acetyltransferase in M. tuberculosis

Cytochrome P450s as a Drug Target

Natural Products as Drug Leads and Caribbean Biodiversity

Evaluation of Biological Activity

METHODS AND MATERIALS

Chemicals

Plant Material: Extraction and Isolation

Expression and Enzymatic Assay for Pure Recombinant NAT fromMycobacterium Smegmatis

CYP Microsomes and Inhibition Assays

Data Analysis

Results

DISCUSSION

Chapter 3: NATURAL PRODUCTS AS INHIBITORS OF THE UBIQUITIN-/UBIQUITIN-LIKE PROTEIN-PROTEASOME PATHWAY

INTRODUCTION.

THE UBIQUITIN-PROTEASOME PATHWAY AND ITS HOMOLOGOUS SYSTEMS

STRUCTURE OF THE PROTEASOME

NATURAL PRODUCTS TARGETING THE PROTEASOME

1. β-Lactones

2. Macrocyclic Compounds

3. Phenolic Compounds

4. Steroid-Like Compounds

5. Triterpenes

NATURAL PRODUCTS TARGETING ENZYMES OF UBIQUITIN ORUBIQUITIN-LIKE PATHWAYS

Natural Products Targeting the E1 Ubiquitin-Activating Enzyme

Natural Products Targeting E1 Ubiquitin-Like Protein-Activating Enzymes

Natural Product Targeting E3 Ubiquitin Ligases

Natural Products Targeting Deubiquitinating Enzymes

BIOSKETCH

Chapter 4: A REVIEW OF THE PLANT ORIGINS,COMPOSITION AND BIOLOGICAL ACTIVITYOF RED PROPOLIS

GEOGRAPHIC AND PLANT ORIGINS OF RED PROPOLIS

COMPOSITION OF RED PROPOLIS

BIOLOGICAL ACTIVITY OF RED PROPOLIS

Chapter 5: NANOENCAPSULATION OF NATURAL PRODUCTS WITH MULTIFUNCTIONAL PROPERTIES IN SILICAAND HYBRID ORGANIC - SILICA HOST MATRICES

1. FUNDAMENTAL ASPECTS OF THE SOL-GEL PROCESS

1.1. Why Sol-Gel Process for Nanomaterial Synthesis?

1.2. Silica and Organo-Silica Matrices Characteristics

1.3. Advances in the Sol-Gel Encapsulation Process

1.3.1. General Aspects

1.3.2. Recent Developments of Sol-Gel Nanomaterials

2. TEMPLATING OF SOL-GEL MICROENVIRONMENT FORSYNTHESIS OF NOVEL FLUORESCENT NANOMATERIALS

2.1. Self-Organisation Approach for the Sol-Gel Microenvironment withTemplate Agents

2.2. The Template Effect on Evolution of Colloidal Sol in Sol-GelEncapsulation

2.3. Synthesis and Fluorescence Properties of Hybrid Nanomaterials withActive Principles

2.3.1. Natural Products with Multifunctional Properties

2.3.2. Sol-Gel Entrapment of Flavonoids and Mixtures of Flavonoids with DifferentKinds of Templates.

3. METHODS FOR PHYSICO-CHEMICAL CHARACTERISATION OFNANOSTRUCTURED MATERIALS OBTAINED BY SOL GEL PROCEDURE

3.1. IR Spectroscopy

3.2. Fluorescence Analysis

3.3. Chemiluminescence Method

3.4. Dynamic Light Scattering

3.5. Transmission Electronic Microscopy Analysis

3.6. Atomic Force Microscopy

CONCLUSION AND PERSPECTIVES

Chapter 6: NATURAL PRODUCTS AS A SOURCE OF POTENTIAL DRUGS FOR THE TREATMENT OF FUNGAL INFECTIONS

2. NATURAL PRODUCTS FROM MICROORGANISMAS ANTIFUNGAL AGENTS

2.1. Natural Products Require More-advanced Studies for the Treatmentof Fungal Infections

2.2. Novel Natural Products with Antifungal Activities

3. BIOLOGICAL ACTIVITY AND THERAPEUTICAPPLICATIONS OF BIOSURFACTANTS

3.1. Glycolipids

3.2. Lipopeptides

3.3. Anti-adhesive Activities of Biosurfactants

4. ANTIFUNGAL ACTIVITY OF PLANTS

4.1. Medicinal Plants with Antifungal Activity

4.2. Compounds from Plants with Antifungal Activity

ACKNOWLEDGMENT

INDEX.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on print version record.

ISBN:

1-62081-737-3

OCLC:

835137793