Theories of population variation in genes and genomes / Freddy Bugge Christiansen.

Format:

Book

Author/Creator:

Christiansen, Freddy B., 1946- author.

Series:

Princeton series in theoretical and computational biology.

Princeton series in theoretical and computational biology

Language:

English

Subjects (All):

Population genetics--Textbooks.

Population genetics.

Physical Description:

1 online resource (496 p.)

Edition:

1st ed.

Place of Publication:

Princeton : Princeton University Press, [2008]

Language Note:

English

Summary:

This textbook provides an authoritative introduction to both classical and coalescent approaches to population genetics. Written for graduate students and advanced undergraduates by one of the world's leading authorities in the field, the book focuses on the theoretical background of population genetics, while emphasizing the close interplay between theory and empiricism. Traditional topics such as genetic and phenotypic variation, mutation, migration, and linkage are covered and advanced by contemporary coalescent theory, which describes the genealogy of genes in a population, ultimately connecting them to a single common ancestor. Effects of selection, particularly genomic effects, are discussed with reference to molecular genetic variation. The book is designed for students of population genetics, bioinformatics, evolutionary biology, molecular evolution, and theoretical biology--as well as biologists, molecular biologists, breeders, biomathematicians, and biostatisticians. Contains up-to-date treatment of key areas in classical and modern theoretical population genetics Provides in-depth coverage of coalescent theory Discusses genomic effects of selection Gives examples from empirical population genetics Incorporates figures, diagrams, and boxed features throughout Includes end-of-chapter exercises Speaks to a wide range of students in biology, bioinformatics, and biostatistics

Contents:

Front matter

Contents

Preface and Acknowledgments

Introduction

Part I. Genetic Variation

1. Genetics

2. Conservation of Variation

3. Diploid Populations

4. Mutation and Variation

5. Migration

6. Linkage

7. Phenotypic Variation

Part II. Variation and Selection

8. Effects of Selection

9. Genomic Effects of Selection

10. Population Structure

A. Probability Theory and Statistics

B. Solutions to Exercises

Bibliography

Index

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on print version record.

ISBN:

9780691165899

0691165890

9781400866656

1400866650

OCLC:

897069884