Predictive toxicology : from vision to reality / edited by Friedlieb Pfannkuch and Laura Suter-Dick ; Arnd Brandenburg [and forty one others], contributors.

Format:

Book

Contributor:

Pfannkuch, Friedlieb, editor.

Suter-Dick, Laura, editor.

Brandenburg, Arnd, contributor.

Series:

Methods and principles in medicinal chemistry ; 64.

Methods and Principles in Medicinal Chemistry ; 64

Language:

English

Subjects (All):

Toxicology.

Physical Description:

1 online resource (433 p.)

Edition:

1st ed.

Place of Publication:

Weinheim, Germany : Wiley-VCH, 2015.

Language Note:

English

Summary:

Tailored to the needs of drug developers, this one-stop reference for medicinal chemists covers all the latest developments in the field of predictive toxicology and its applications in safety assessment. With a keen emphasis on novel approaches, the topics have been tackled by selected expert scientists, who are familiar with the theoretical scientific background as well as with the practical application of current methods. Emerging technologies in toxicity assessment are introduced and evaluated in terms of their predictive power, with separate sections on computer predictions and simulation

Contents:

Predictive Toxicology: From Vision to Reality; Contents; List of Contributors; Preface; A Personal Foreword; 1 Introduction to Predictive Toxicology Tools and Methods; 1.1 Computational Tools and Bioinformatics; 1.1.1 In Silico Prediction Tools; 1.1.2 Bioinformatics; 1.2 Omics Technologies; 1.2.1 Toxicogenomics (Transcriptomics); 1.2.2 Proteomics; 1.2.3 Metabolomics; 1.3 Data Interpretation and Knowledge Management; 1.4 Biomarker Development; 1.5 Advanced In Vitro Systems and Stem Cell Research; 1.5.1 Advanced In Vitro Testing; 1.5.2 Stem Cell Research; 1.6 Immunogenicity

1.7 Integration and Validation1.7.1 Use of Omics for Toxicology Testing; 1.7.2 Integration of "New" Technologies into Risk Assessment; 1.7.3 Use of Human-Derived Cellular Systems; 1.7.4 "General" Acceptance - Translation into Guidelines; 1.8 Research Initiative/Collaborations; 1.9 Concluding Remarks; References; 2 In Silico Toxicology - Current Approaches and Future Perspectives to Predict Toxic Effects with Computational Tools; 2.1 Introduction; 2.2 Prediction of Hazard; 2.2.1 Definition of Hazard and Its Use; 2.2.2 Prediction of Mutagenicity; 2.2.3 Prediction of Phospholipidosis

2.2.4 Prediction of Carcinogenicity2.2.5 Prediction of Skin Sensitization; 2.2.6 Prediction of Skin and Eye Irritation; 2.2.7 Approaches to Systemic Toxicity Prediction; 2.2.7.1 The Cramer Classes; 2.2.7.2 Predicting Toxic Doses of Drugs; 2.2.7.3 Predicting Organ Toxicity; 2.2.7.4 Adverse Outcome Pathways and Potential for Prediction; 2.3 Prediction of Risk; 2.3.1 Risk Definition and Some Basic Considerations; 2.3.2 Data Availability; 2.3.3 Database Structure and Data Curation; 2.3.4 Approaches to Model and Predict Risk; 2.4 Thoughts on Validation; 2.5 Conclusions and Outlook; References

3 In Silico Approaches: Data Management - Bioinformatics3.1 Introduction; 3.2 Experimental Setup and Statistical Power; 3.3 Properties of Different Omics Data; 3.3.1 Next-Generation Sequencing Data; 3.3.2 DNA Methylation Data; 3.3.3 miRNA Data; 3.3.4 CNV and SNP Data; 3.3.5 ChIP-seq Data; 3.3.6 Gene Expression Microarray Data (Affymetrix); 3.3.7 Mass Spectrometry Data; 3.3.8 Missing Values and Zero Values; 3.3.9 Data Normalization; 3.4 Statistical Methods; 3.4.1 Data Overviews; 3.4.2 Null Hypothesis/Type I and Type II Errors; 3.4.3 Multiple Testing Methods; 3.4.4 Statistical Tests

3.4.5 Linear Models and Linear Mixed Models3.5 Prediction and Classification; 3.5.1 Overview; 3.5.2 Generating a Reference Compendium of Compounds; 3.5.3 Cross-Validation; 3.5.4 Selection Bias; 3.6 Combining Different Omics Data and Biological Interpretations; 3.7 Data Management; References; 4 Role of Modeling and Simulation in Toxicology Prediction; 4.1 Introduction; 4.2 The Need to Bring PK and PD in Predictive Models Together; 4.2.1 Physiologically Based Pharmacokinetic Modeling; 4.2.2 Mathematical (PBPK, PK/PD) Modeling; 4.2.3 Predictive Tools; 4.3 Methodological Aspects and Concepts

4.3.1 "Cascading" Drug Effects

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters and index.

Description based on online resource; title from PDF title page (ebrary, viewed October 30, 2014).

Current copyright fee: GBP28.00 35\0.

ISBN:

9783527674206

3527674209

9783527674190

3527674195

9783527674183

3527674187

OCLC:

893739321