Drug discovery handbook / edited by Shayne Cox Gad.

Format:

Book

Contributor:

Gad, Shayne C., 1948-

Series:

Pharmaceutical Development Series

Pharmaceutical Development Series ; v.1

Language:

English

Subjects (All):

Drugs--Research--Handbooks, manuals, etc.

Drugs.

Drug development--Handbooks, manuals, etc.

Drug development.

Drugs--Design--Handbooks, manuals, etc.

Pharmaceutical chemistry--Handbooks, manuals, etc.

Pharmaceutical chemistry.

Physical Description:

1 online resource (1493 p.)

Edition:

1st ed.

Place of Publication:

Hoboken, N.J. : Wiley-Interscience, c2005.

Language Note:

English

Summary:

The Drug Discovery Handbook gives professionals a tool to facilitate drug discovery by bringing together, for the first time in one resource, a compendium of methods and techniques that need to be considered when developing new drugs.This comprehensive, practical guide presents an explanation of the latest techniques and methods in drug discovery, including: Genomics, proteomics, high-throughput screening, and systems biology Summaries of how these techniques and methods are used to discover new central nervous system agents, antiviral agents, respiratory drugs, oncolo

Contents:

Drug discovery in the 21st century: an introduction / Shayne C. Gad

Natural products / Charles B. Spainhour

Cancer cell proteomics using molecular aptamers / Weihong Tan, Zehui Cao, Dihua Shangguang

Molecular similarity methods and QSAR models as tools for virtual screening / Jurgen Bajorath

Systems biology: applications in drug discovery / Sean Ekins ...[et al.]

High throughput flow cytometry / Larry A. Sklar ... [et al.]

Combining NMR spectral information with associated structural features to form computationally non-intensive, rugged, and objective models of biological activity / Richard Beger, Dan A. Buzatu, Jon G. Wilkes

Using Microsoft Excel as a laboratory data management tool / A. Erik Rubin, Mark F. Russo, William Neil

The age of regulation / Sandy Weinberg, Gerald J. Whartenby

Simultaneous screening of multiple cell lines using the CellCardtm system / Oren E. Beske

Protein x-ray crystallography in drug discovery / Peter Nollert ...[et al.]

Biological and chemistry assays available during drug discovery and developability assessment / Duane B. Lakings

Strategies and methods in monitoring and targeting protein-protein interactions / Arianna Loregian, Giorgio Palu

High throughput screening: evolution of technology and methods

Martyn N. Banks ... [et al.]

Metal-enhanced fluorescence: application to high-throughput screening and drug discovery / Kadir Aslan .. [et al,]

Methods for the design and analysis of replicate-experiment studies to establish assay reproducibility and the equivalence of two potency assays / Brian J. Eastwood ... [et al.]

Coupled luminescent methods in drug discovery: three-minute assays for cytotoxicity and phosphatase activity / Michael J. Corey, Robert J. Kinders

Design and pharmaceutical applications of prodrugs / Tomi Jarvinen ... [et al.]

GABA and glutamate receptor ligands and their therapeutic potential in CNS disorders / Ulf Madsen ... [et al.]

Cardiac sarcolemmal ATP-sensitive potassium channel antagonists: novel ischemia-selective antiarrhythmic agents / George E. Billman

Factors influencing the efficacy of mediator-specific anti-inflammatory, glucocorticoid and anti-coagulant therapies for sepsis / Peter C. Minneci ... [et al.]

Combinatorial chemistry in the drug discovery process / Nathan T. Ross, Brian R. McNaughton, Benjamin L. Miller

Herbal medicines and animal models of gastrointestinal diseases / C.H. Cho, J.K.S. Ko

Endocrine and metabolic agents / Brian L. Furman

Respiratory viruses / Paul D. Olivo

Strategies in the design of antiviral drugs / Erik De Clercq, Piet Herdewijn

Protein kinase inhibitors in drug discovery / Keykavous Parang, Gongqin Sun

RNA-based therapies / Ingmar Hoerr, Steve Pascolo

Novel imaging agents for molecular MR imaging of cancer / Dmitri Artemov, Zaver M. Bhujwalla

Genomics-based drug discovery / Spyro Mousses

Cancer drug discovery / Susan Mooberry.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-280-27707-6

9786610277070

0-470-30589-4

0-471-72877-2

0-471-72878-0

OCLC:

475938707