Innovative strategies in tissue engineering / editors, Mayuri Prasad, Paolo di Nardo.

Format:

Book

Author/Creator:

Prasad, Mayuri., Editor.

Contributor:

Prasad, Mayuri, editor.

Di Nardo, Paolo, editor.

Series:

River publishers series in research and business chronicles: biotechnology and medicine ; Volume 2.

River Publishers Series in Research and Business Chronicles: Biotechnology and Medicine ; Volume 2

Language:

English

Subjects (All):

Tissue engineering--Congresses.

Tissue engineering.

Nanocomposites (Materials)--Congresses.

Nanocomposites (Materials).

Biomedical materials--Congresses.

Biomedical materials.

Stem cells--Congresses.

Stem cells.

Physical Description:

1 online resource (211 pages) : illustrations (some color), charts, photographs, graphs.

Edition:

1st ed.

Place of Publication:

Taylor & Francis 2015

Aalborg, Denmark : River Publishers, 2015.

Language Note:

English

Summary:

In spite of intensive investments and investigations carried out in the last decade, many aspects of the stem cell physiology, technology and regulation remain to be fully defined. After the enthusiasm that characterized the first decade of the discovery that when given the right cue, stem cells could repair all the different tissues in the body; it is now time to start a serious and coordinated action to define how to govern the stem cell potential and to exploit it for clinical applications. This can be achieved only with shared research programs involving investigators from all over the world and making the results available to all.The Disputationes Workshop series (http://disputationes.info) is an international initiative aimed at disseminating stem cell related cutting edge knowledge among scientists, healthcare workers, students and policy makers. The present book gathers together some of the ideas discussed during the third and fourth Disputationes Workshops held in Florence (Italy) and Aalborg (Denmark), respectively. The aim of this book is to preserve those ideas in order to contribute to the general discussion on organ repair and to bolster a fundamental scientific and technological leap forwards the treatment of otherwise incurable diseases.

Contents:

Cover

Half Title

Title

Copyright

Contents

Preface

List of Figures

List of Abbreviations

1. Bioactive Nanocomposites withApplications in Biomedicine

Abstract

1.1 Introduction

1.2 Factors that Influence the Quality of a Biomaterial

1.3 Layered Silicate Nanocomposites for Biomaterials

1.3.1 Layered Silicate Properties

1.3.2 Layered Silicate Purification

1.3.3 Layered Silicate in Drug Release Systems

1.3.4 Biopolymers Properties

1.4 Routes for Obtaining Bio-Nanocomposites

1.5 Biomaterials Development

1.6 Conclusions

References

2. Cerium Dioxide Nanoparticles ProtectCardiac Progenitor Cells against theOxidative Stress

2.1 Interaction of Cerium Oxide Nanoparticleswith Biological Systems

2.2 Cerium Oxide Nanoparticles Shield Cardiac PrecursorCells against the Oxidative Stress

3. Animals Models and In Vitro Alternativesin Regenerative Medicine: Focus onBiomaterials Development

3.1 Introduction

3.1.1 Animals in Medical Research

3.1.2 Ethical Considerations of Animal Use

3.2 Designing Animal Experiments

3.2.1 Randomization and Blinding

3.2.2 Control Groups

3.2.3 Statistical Analysis

3.2.4 Design Stages

3.3 Limitations of Animal Models

3.3.1 Animal Species

3.3.2 Health and Age Status

3.3.3 Reproducibility

3.4 Examples of Animal Models for Cardiac and CornealRegenerative Medicine Testing

3.4.1 Myocardial Infarct and Other Ischemic Models

3.4.1.1 Myocardial coronary artery ligation

3.4.1.3 Hind-limb ischemia

3.4.1.2 Cryoinjury

3.4.2 Corneal Transplantation Models

3.4.2.1 Animal species

3.4.2.2 Lamellar and penetrating keratoplasty

3.4.2.3 Infectious models

3.5 In Vitro Systems as Alternatives to Animal Testing

3.5.1 In Vitro Corneal Equivalents for Screening Biomaterialsas Potential Implants.

3.5.2 In Vitro Angiogenesis Models

3.6 Conclusion

4. Differentiation Plasticity of Germ line Cell-Derived Pluri potent Stem Cells and Their Potential Application in Regenerative Medic

4.1 Introduction

4.2 Hepatocytes Derived from GPSCs

4.3 Cardiac Cells Derived from GPSCs

4.4 Neuronal Cells Derived from GPSCs

4.5 Hematopoietic Cells from GPSCs

4.6 Vascular Cells Derived from GPSCs

5. Mechanical Stimulation in Tissue Engineering

5.1 Background and Introduction

5.1.1 Mechanical Theories of Material Damage

5.1.2 Damage of Living Tissue

5.2 Mechanical Loading in Two Dimensions

5.2.1 Hertz-inspired Tissue Deformation

5.2.2 Preliminary Results of Cell Straining

5.3 Conclusions and Outlook

6. Immune Properties of Mesenchymal Stem Cells in the Translation of Neural Disorders

6.1 Introduction

6.2 MSC Immunology

6.3 MSCs and Cancer

6.3.1 Role in Tumor Growth

6.3.2 MSCs in Tumor Suppression

6.3.3 MSC and Brain Cancer

6.4 Regenerative Potential

6.5 Safety

6.6 Conclusion

7. Novel Design of Manufacturing Bioreactor and Facility of Cell-Based Health Care Products for Regenerative Medicine

7.1 Introduction

7.2 Bioreactor Design for Cell Processing

7.3 Facility Design for Cell Processing

7.4 Flexible Modular Platform Technology

7.5 Acknowledgments

8. Insight into Melanoma Stem Cells:The Role of the Hedgehog Signaling in Regulating Self-Renewal and Tumorigenicity

8.1 Introduction

8.2 Evidence for the Existence of Melanoma Stem Cells with Self-Renewing and Tumorigenic Properties

8.3 The Hedgehog Signaling Pathway

8.4 Role of the Hedgehog Signaling in Regulating Self-Renewal and Tumorigenicity of Melanoma Stem Cells

8.5 Conclusions

8.6 Acknowledgement.

References

9. A Quest for Refocussing Stem CellInduction Strategies: How to Deal with Ethical Objections and Patenting Problems

9.1 Introduction

9.2 Potential for Autonomous Pattern Formation:Embryoid Bodies

9.3 Potential for Assisted Development:Tetraploid Complementation

9.4 Pluripotency, an Obstacle for Patenting

9.5 Alternative Approaches

9.6 Conclusions

9.7 Acknowledgments

10. Constitutive Equations in FiniteViscoplasticity of Nanocomposite Hydrogels

10.1 Introduction

10.2 Constitutive Model

10.2.1 Kinematic Relations

10.2.2 Free Energy Density of a Hydrogel

10.2.3 Derivation of Constitutive Equations

10.3 Simplification of the Constitutive Equations

10.4 Fitting of Observations

10.4.1 Nanocomposite Hydrogels Subjected to Dryingand Swelling

10.4.2 As-Prepared Poly(Dimethylacrylamide)-Silica Hydrogels

10.4.3 As-Prepared Polyacrylamide-Clay Hydrogels

10.4.4 Discussion

10.5 Concluding Remarks

10.6 Acknowledgement

11. Regulatory Issues in Developing Advanced Therapy Medicinal Products with Stem Cells in Europe

11.1 Introduction

11.2 European Regulatory Frame for ATMP

11.3 Stem Cell-Based ATMP

11.4 Quality Issues for Stem Cell-Based Product Development

11.5 Non Clinical Issues for Stem Cell-Based Product Development

11.6 Clinical Issues for Stem Cell-Based Product Development

11.7 Conclusion

Index

Editor's Biographies.

Notes:

Includes bibliographical references at the end of each chapters and index.

CC BY-NC-ND

Description based on print version record.

ISBN:

9781000792737

1000792730

9781003338574

1003338577

9788793237100

8793237103

OCLC:

957125869