Bioreactors : design, operation and novel applications / edited by Carl-Fredrik Mandenius.

Format:

Book

Contributor:

Mandenius, Carl-Fredrik, editor.

Language:

English

Subjects (All):

Bioreactors--Design and construction.

Bioreactors.

Physical Description:

1 online resource (603 p.)

Edition:

1st ed.

Place of Publication:

Weinheim, Germany : Wiley-VCH Verlag GmbH & Company KGaA, [2016]

Summary:

In this expert handbook both the topics and contributors are selected so as to provide an authoritative view of possible applications for this new technology. The result is an up-to-date survey of current challenges and opportunities in the design and operation of bioreactors for high-value products in the biomedical and chemical industries. Combining theory and practice, the authors explain such leading-edge technologies as single-use bioreactors, bioreactor simulators, and soft sensor monitoring, and discuss novel applications, such as stem cell production, process development, and multi-product reactors, using case studies from academia as well as from industry. A final section addresses the latest trends, including culture media design and systems biotechnology, which are expected to have an increasing impact on bioreactor design. With its focus on cutting-edge technologies and discussions of future developments, this handbook will remain an invaluable reference for many years to come.

Contents:

Title Page; Copyright; Table of Contents; Preface; List of Contributors; Chapter 1: Challenges for Bioreactor Design and Operation; 1.1 Introduction; 1.2 Biotechnology Milestones with Implications on Bioreactor Design; 1.3 General Features of Bioreactor Design; 1.4 Recent Trends in Designing and Operating Bioreactors; 1.5 The Systems Biology Approach; 1.6 Using Conceptual Design Methodology; 1.7 An Outlook on Challenges for Bioreactor Design and Operation; References; Chapter 2: Design and Operation of Microbioreactor Systems for Screening and Process Development; 2.1 Introduction

2.2 Key Engineering Parameters and Properties in Microbioreactor Design and Operation2.3 Design of Novel Stirred and Bubble Aerated Microbioreactors; 2.4 Robotics for Microbioreactors; 2.5 Fed-Batch and Continuous Operation of Microbioreactors; 2.6 Monitoring and Control of Microbioreactors; 2.7 Conclusion; References; Chapter 3: Bioreactors on a Chip; 3.1 Introduction; 3.2 Advantages of Microsystems; 3.3 Scaling Down the Bioreactor to the Microfluidic Format; 3.4 Microfabrication Methods for Bioreactors-On-A-Chip; 3.5 Fabrication Materials

3.6 Integrated Sensors for Key Bioreactor Parameters3.7 Model Organisms Applied to BRoCs; 3.8 Applications of Microfluidic Bioreactor Chip; 3.9 Scale Up; 3.10 Conclusion; References; Chapter 4: Scalable Manufacture for Cell Therapy Needs; 4.1 Introduction; 4.2 Requirements for Cell Therapy; 4.3 Stem Cell Types and Products; 4.4 Paradigms in Cell Therapy Manufacture; 4.5 Cell Therapy Manufacturing Platforms; 4.6 Microcarriers and Stirred-Tank Bioreactors; 4.7 Future Trends for Microcarrier Culture; 4.8 Preservation of Cell Therapy Products; 4.9 Conclusions; References

Chapter 5: Artificial Liver Bioreactor Design5.1 Need for Innovative Liver Therapies; 5.2 Requirements to Liver Support Systems; 5.3 Bioreactor Technologies Used in Clinical Trials; 5.4 Optimization of Bioartificial Liver Bioreactor Designs; 5.5 Improvement of Cell Biology in Bioartificial Livers; 5.6 Bioreactors Enabling Cell Production for Transplantation; 5.7 Cell Sources for Bioartificial Liver Bioreactors; 5.8 Outlook; References; Chapter 6: Bioreactors for Expansion of Pluripotent Stem Cells and Their Differentiation to Cardiac Cells; 6.1 Introduction

6.2 Culture Technologies for Pluripotent Stem Cell Expansion6.3 3D Suspension Culture; 6.4 Autologous Versus Allogeneic Cell Therapies: Practical and Economic Considerations for hPSC Processing; 6.5 Upscaling hPSC Cardiomyogenic Differentiation in Bioreactors; 6.6 Conclusion; References; Chapter 7: Culturing Entrapped Stem Cells in Continuous Bioreactors; 7.1 Introduction; 7.2 Materials Used in Stem Cell Entrapment; 7.3 Synthetic Materials; 7.4 Natural Materials; 7.5 Manufacturing and Regulatory Constraints; 7.6 Mass Transfer in the Entrapment Material

7.7 Continuous Bioreactors for Entrapped Stem Cell Culture

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on online resource; title from PDF title page (ebrary, viewed April 7, 2016).

ISBN:

9783527683383

3527683380

9781523115198

152311519X

9783527683369

3527683364

9783527683376

3527683372

OCLC:

945873904