Physiologically-based pharmacokinetic (PBPK) modeling and simulations : principles, methods, and applications in the pharmaceutical industry / Sheila Annie Peters.

Format:

Book

Author/Creator:

Peters, Sheila Annie.

Language:

English

Subjects (All):

Pharmacokinetics--Mathematical models.

Pharmacokinetics.

Drugs--Design--Mathematical models.

Drugs.

Physical Description:

1 online resource (450 p.)

Edition:

1st ed.

Place of Publication:

Hoboken, N.J. : Wiley, c2011.

Language Note:

English

Summary:

The only book dedicated to physiologically-based pharmacokinetic modeling in pharmaceutical science Physiologically-based pharmacokinetic (PBPK) modeling has become increasingly widespread within the pharmaceutical industry over the last decade, but without one dedicated book that provides the information researchers need to learn these new techniques, its applications are severely limited. Describing the principles, methods, and applications of PBPK modeling as used in pharmaceutics, Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations fills this void. Connecting

Contents:

Modelling in the pharmaceutical industry

Physiologically-based modelling

A review of pharmacokinetic principles

Physiological model for absorption

Physiological model for distribution

Physiological models for drug metabolism and excretion

Generic whole-body physiologically-based pharmacokinetic modelling

Variability, uncertainty and sensitivity analysis

Evaluation of drug-drug interaction risk with pbpk models

PBPK of biotherapeutics

Data integration and sensitivity analysis

Hypothesis generation and pharmacokinetic predictions

Integration of PBPK and pharmacodynamics

PBPK modelling of populations

PBPK models along the drug discovery and development value chain.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-280-58863-2

9786613618467

1-118-14030-3

1-118-14029-X

1-118-14038-9

OCLC:

784136896