Handbook of Cell Signaling.

Format:

Book

Author/Creator:

Bradshaw, Ralph A., 1941-

Contributor:

Dennis, Edward A. (Biochemist)

Series:

Cell Biology

Language:

English

Subjects (All):

Cell interaction.

Cellular signal transduction.

Local Subjects:

Cell interaction.

Cellular signal transduction.

Physical Description:

1 online resource (3188 p.)

Edition:

2nd ed.

Place of Publication:

Burlington : Elsevier Science, 2009.

Language Note:

English

Summary:

KEY FEATURES:* Contains over 350 chapters of comprehensive coverage on cell signaling * Includes discussion on topics from ligand/receptor interactions to organ/organism responses* Provides user-friendly, well-illustrated, reputable content by experts in the fieldDESCRIPTION:Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an u

Contents:

e9780123741455v1; Front Cover; Handbook of Cell Signaling; Copyright Page; Contents; Contributors; Preface to the Second Edition; Preface to the First Edition; Chapter 1. Cell Signaling: Yesterday, Today, and Tomorrow; ORIGINS OF CELL SIGNALING; ENTER POLYPEPTIDE GROWTH FACTORS; CELL SIGNALING AT THE MOLECULAR LEVEL; LIPID SIGNALING; CELL SIGNALING TOMORROW; REFERENCES; Part I: Initiation: Extracellular and Membrane Events; INTRODUCTION; Section A - Molecular Recognition; Chapter 2. Structural and Energetic Basis of Molecular Recognition; INTRODUCTION; PRINCIPLES OF BINDING

NON-SPECIFIC ASSOCIATION WITH MEMBRANE SURFACESPROTEIN-PROTEIN INTERACTIONS; PROSPECTS; REFERENCES; Chapter 3. Free Energy Landscapes in Protein-Protein Interactions; THERMODYNAMICS OF PROTEIN-PROTEIN INTERACTIONS; INTERACTION KINETICS; DISSOCIATION OF A PROTEIN COMPLEX; THE MODULAR STRUCTURE OF PROTEIN-PROTEIN BINDING SITES; INTERACTION BETWEEN MEMBRANE-ANCHORED PROTEINS; SUMMARY; REFERENCES; Chapter 4. Molecular Sociology; TRANSMEMBRANE SIGNALING PARADIGMS; STRUCTURAL BASIS OF PROTEIN-PROTEIN RECOGNITION; CONCLUSION; REFERENCES

Chapter 5. Antibody-Antigen Recognition and Conformational ChangesINTRODUCTION; ANTIBODY ARCHITECTURE; CONFORMATIONAL CHANGES; UNUSUAL STRUCTURAL MODIFICATIONS; CONCLUSION; ACKNOWLEDGEMENTS; REFERENCES; Chapter 6. Binding Energetics in Antigen-Antibody Interfaces; INTRODUCTION; THERMODYNAMIC MAPPING OF ANTIGEN-ANTIBODY INTERFACES; CONCLUSIONS; REFERENCES; Chapter 7. Immunoglobulin-Fc Receptor Interactions; INTRODUCTION; IMMUNOGLOBULIN STRUCTURE; Fc RECEPTORS AND THEIR STRUCTURES; IgG-RECEPTOR INTERACTIONS; IgE-RECEPTOR INTERACTIONS; IgA-RECEPTOR INTERACTIONS; CONCLUSIONS; REFERENCES

Chapter 8. Ig-Superfold and its Variable Uses in Molecular RecognitionINTRODUCTION; THE IMMUNOGLOBULIN SUPERFAMILY; IG-SUPERFOLD-MEDIATED RECOGNITION; REFERENCES; Chapter 9. T Cell Receptor/pMHC Complexes; TCR GENERATION AND ARCHITECTURE; PEPTIDE BINDING TO MHC CLASS IA AND II; TCR/pMHC INTERACTION; ORIENTATION OF THE TCR IN TCR/PMHC COMPLEXES; PEPTIDE RECOGNITION BY THE TCR CDR LOOPS; DISCREPANCY BETWEEN MAGNITUDE OF STRUCTURAL CHANGES AND BIOLOGICAL OUTCOMES; ROLE OF BOUND WATER IN TCR/pMHC RECOGNITION; CONCLUSIONS AND FUTURE PERSPECTIVES; REFERENCES

Chapter 10. Mechanistic Features of Cell-Surface Adhesion ReceptorsMECHANOSENSORY MECHANISMS; CELL-CELL ADHESIONS/ADHERENS JUNCTIONS; T CELL CO-STIMULATION; AXON GUIDANCE AND NEURAL DEVELOPMENT; CONCLUSIONS; REFERENCES; Chapter 11. The Immunological Synapse; INTRODUCTION; MIGRATION AND THE IS; THE MEMBRANE-CYTOSKELETON COMPLEX AND THE IS; REQUIREMENTS FOR TCR TRIGGERING; INTEGRATION OF ADAPTIVE AND INNATE RESPONSES; ROLE OF IS IN T CELL DIFFERENTION; SUMMARY; ACKNOWLEDGMENTS; REFERENCES; Chapter 12. NK Receptors; IMMUNORECEPTORS; NATURAL KILLER CELLS; IG-TYPE NK RECEPTORS: KIR

OTHER IG-TYPE RECEPTORS ON NK CELLS

Notes:

Description based upon print version of record.

ISBN:

9786612954023

9780123741486

0123741483

9781282954021

1282954024

9780080920917

0080920918

OCLC:

701704029