Host - pathogen interaction : microbial metabolism, pathogenicity and antiinfectives / edited by Gottfried Unden, Eckhard Thines, and Anja Schüffler.

Format:

Book

Contributor:

Unden, Gottfried, editor.

Thines, Eckhard, editor.

Schüffler, Anja, editor.

Series:

Drug discovery in infectious diseases.

Drug discovery in infectious diseases

Language:

English

Subjects (All):

Host-parasite relationships.

Communicable diseases.

Infection.

Pathogenic microorganisms.

Anti-infective agents.

Physical Description:

1 online resource (237 pages.)

Edition:

1st ed.

Place of Publication:

Weinheim, Germany : Wiley-VCH Verlag GmbH & Company KGaA, 2016.

Language Note:

English

Summary:

In light of the rapidity increasing incidence rate of bacterial and fungal infections with multi-resistant pathogens, the metabolic changes associated with host-pathogen interactions offer one of the most promising starting points for developing novel antibiotics.. Part one of this comprehensive guide describes the metabolic adaptation of pathogenic microbes in humans, while part two points to routes for the development of novel antibiotics. This is volume six of the book series on drug discovery in infectious diseases by Paul Selzer.

Contents:

Cover; Title Page; Copyright; Contents; Preface; Cover Legend; List of Contributors; Part One Adaptation of Microbial Metabolism in Host/Pathogen Interaction; Chapter 1 Metabolic Adaptation of Human Pathogenic Yersiniae; Introduction; Yersinia Life Cycles and Pathogenesis; Carbon Metabolism and Links to Yersinia Pathogenesis; Food Sources, Nutrient Sequestration, and Utilization; Metabolic Pathways of Yersinia Crucial for Virulence; Nutritional Virulence: Nutritional Adaptation Important for Pathogenesis; Coordinated Control of Carbon Metabolism and Virulence; Importance of Ions

Importance of the Csr SystemImportance of CCR and the cAMP-Crp Complex; Importance of Posttranscriptional Regulation Strategies; Conclusions; Acknowledgments; References; Chapter 2 Crosstalk between Metabolism and Virulence of Legionella pneumophila; Introduction; Key Metabolic Features of L. pneumophila; Serine and Glucose Metabolism of L. pneumophila under In Vitro Conditions; Metabolism of L. pneumophila under Intracellular Conditions; Metabolic Adaptation during the Life Cycle of Intracellular L. pneumophila; Metabolic Host Cell Responses Triggered by Intracellular L. pneumophila

ConclusionReferences; Chapter 3 Metabolism of Intracellular Salmonella enterica; Introduction; S. enterica-A Metabolic Generalist; Metabolism of Glucose by S. enterica; Connection to the TCA Cycle by Oxidative Decarboxylation of Pyruvate; The Important Role of the TCA Cycle and Anaplerotic Reactions; Metabolism of Intracellular S. enterica; The Metabolism of S. enterica Compared to Other Important Intracellular and Gastrointestinal Pathogens; Salmonella Induce Networks of Tubular Structures-Access to Host-Derived Nutrients?; S. enterica Has a Bimodal Lifestyle in Epithelial Cells

Salmonella Metabolism Limits Possibilities for New AntimicrobialsConclusions; References; Chapter 4 The Human Microbiome in Health and Disease; Introduction; Methods for Characterizing the Microbiota; Diet and Geographical Factors; Functional Gastrointestinal Disorders; Manipulation of the Microbiota; Conclusions; Acknowledgments; References; Chapter 5 Mechanisms of Dysbiosis in the Inflamed Gut; Introduction; Dysbiosis during Inflammatory Diseases of the Gastrointestinal Tract; Nutrient Acquisition by Commensal Bacteria in the Normal Gut

Nutritional Mechanisms for Dysbiosis in the Inflamed GutInflammation-Driven Bloom of Enteric Pathogens in the Gut Lumen; How Anaerobic Respiration Enhances Growth in the Inflamed Gut; Conclusions; References; Chapter 6 Strategies for Nutrient Acquisition by Magnaporthe oryzae during the Infection of Rice; Introduction; Adhesion and Germination; Appressorium Formation; Penetration; Growth in Planta: The Biotrophic Growth Phase; Growth in Planta: Necrotrophic Growth Phase; Growth in Planta: Sporulation; Life Outside of the Rice Plant; Conclusion; References

Part Two New Inhibitors and Targets of Infectious Diseases

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on online resource; title from PDF title page (ebrary, viewed March 26, 2016).

ISBN:

9783527682416

3527682414

9783527682386

3527682384

9783527682393

3527682392

OCLC:

945612679