Genomics, proteomics and metabolomics in nutraceuticals and functional foods / editors, Debasis Bagchi, Anand Swaroop, Manashi Bagchi.

Format:

Book

Contributor:

Bagchi, Debasis, 1954- editor.

Swaroop, Anand, editor.

Bagchi, Manashi, editor.

Series:

Hui: Food Science and Technology

Language:

English

Subjects (All):

Functional foods.

Dietary supplements.

Genomics.

Proteomics.

Functional genomics.

Physical Description:

1 online resource (1181 p.)

Edition:

Second edition.

Place of Publication:

Chichester, England : Wiley Blackwell, 2015.

Language Note:

English

Summary:

Functional foods and nutraceuticals have received considerable interest in the past decade largely due to increasing consumer awareness of the health benefits associated with food. Diet in human health is no longer a matter of simple nutrition: consumers are more proactive and increasingly interested in the health benefits of functional foods and their role in the prevention of illness and chronic conditions. This, combined with an aging population that focuses not only on longevity but also quality of life, has created a market for functional foods and nutraceuticals. A fully updated and revised second edition, Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods reflects the recent upsurge in "omics" technologies and features 48 chapters that cover topics including genomics, proteomics, metabolomics, epigenetics, peptidomics, nutrigenomics and human health, transcriptomics, nutriethics and nanotechnology. This cutting-edge volume, written by a panel of experts from around the globe reviews the latest developments in the field with an emphasis on the application of these novel technologies to functional foods and nutraceuticals.

Contents:

Intro

Title Page

Table of Contents

Contributors

Preface

Part I: Introduction

1 Novel Omics Technologies in Food Nutrition

1.1 Introduction

1.2 Transcriptomics in Nutritional Research

1.3 Proteomics in Nutritional Research

1.4 Metabolomics in Nutritional Research

1.5 Systems Biology in Nutritional Research

1.6 Conclusions

References

2 Seafood Authentication using Foodomics: Proteomics, Metabolomics, and Genomics

2.1 Introduction

2.2 Proteomic Approaches

2.3 Metabolomic Approaches

2.4 Genomic Approaches

2.5 Conclusions

3 A Foodomics Approach Reveals Hypocholesterolemic Activity of Red Microalgae

3.1 Introduction

3.2 Marine Functional Foods and Supplements

3.3 Microalgae

3.4 Summary

Part II: Genomics

4 Gene-Diet Interaction and Weight Management

4.1 Introduction

4.2 Diet and Lifestyle Modifications in Weight Management

4.3 The Role of Genetic Factors in Determining Body Weight and Weight Loss

4.4 Gene-Diet Interactions on Body Weight and Risk of Obesity

4.5 Gene-Diet Interactions on Weight Loss in Randomized Clinical Trials

4.6 Gene-Diet Interactions on Weight Maintenance

4.7 Personalized Weight Management through Diet and Lifestyle Modifications

4.8 Summary and Concluding Remarks

Acknowledgments

5 NutrimiRomics: The Promise of a New Discipline in Nutrigenomics

5.1 Introduction

5.2 miRomics: A New Cornerstone

5.3 Nutrigenomics and miR

6 Genomics as a Tool to Characterize Anti-inflammatory Nutraceuticals

6.1 Chronic Inflammation in Disease

6.2 Nutraceuticals in the Management of Chronic Inflammation

6.3 GeneChipTM as a Tool to Characterize the Anti-Inflammatory Properties of Nutraceuticals

7 Nutrigenomics, Inflammaging, and Osteoarthritis: A Review.

7.1 Introduction

7.2 Osteoarthritis (OA)

7.3 Antioxidants and the Inflammatory Microenvironment

7.4 Inflammaging

7.5 Nutrigenomics

7.6 Muscle Inflammation in OA

7.7 Conclusions

Acknowledgments, Competing Interests, and Disclosures

8 Genetic Basis of Anti-Inflammatory Properties of Boswellia Extracts

8.1 Introduction

8.2 Boswellia serrata

8.3 Mechanism of Action

8.4 Development of 5-Loxin® (BE-30)

8.5 Gene Chip Probe Array Analysis

8.6 Proteomics

8.7 Molecular Basis of Anti-Inflammatory Properties of 5-LOXIN ®

8.8 In vivo Studies

8.9 Safety of 5-LOXIN ®

8.10 Clinical Efficacy of 5-LOXIN ® in the Management of Osteoarthritis

8.11 An Advanced 5-LOXIN®: Aflapin®

8.12 Conclusion

9 Cancer Chemopreventive Phytochemicals Targeting NF-κB and Nrf2 Signaling Pathways

9.1 Introduction

9.2 Molecular-Based Cancer Chemoprevention

9.3 Nuclear Factor-Kappa B (NF-κB)

9.4 Nrf2

9.5 Interplay/Crosstalk between Nrf2 and NF-κB Signaling Pathways

9.6 Conclusion

Acknowledgment

10 The Beneficial Health Effects of Fucoxanthin

10.1 Introduction

10.2 The Beneficial Health Effects of Carotenoids as Antioxidants

10.3 Anticancer Activity of Fucoxanthin

10.4 Anti-Obesity Effects of Fucoxanthin

10.5 Anti-Diabetic Effects of Fucoxanthin

10.6 Conclusion

11 Nutrition, Genomics, and Human Health: A Complex Mechanism for Wellness

11.1 Introduction

11.2 Nutrition Sciences and Clinical Applications in Nutritional Genomics

12 Application of Genomics and Bioinformatics Analysis in Exploratory Study of Functional Foods

12.1 Introduction

12.2 Analysis Tools

12.3 Interpretation Tools

12.4 Application Example of Kale (Brassica oleracea L. Var Acephala DC)

12.5 Conclusion

References.

13 Omics Analysis and Databases for Plant Science

13.1 Introduction

13.2 NGS Technologies and Data Processing

13.3 De novo Plant Genome Assembly by NGS

13.4 Plant Genome Resequencing by NGS

13.5 Plant Transcriptome Analysis by NGS

13.6 Plant Genome and Annotation Databases

13.7 Plant Omics Databases

13.8 Conclusion

14 Synergistic Plant Genomics and Molecular Breeding Approaches for Ensuring Food Security

14.1 Introduction

14.2 Plant Genomics, Transcriptomics, Proteomics, and Metabolomics Resources

14.3 Molecular Markers in Plant Genome Analysis

14.4 Identification of Functionally Relevant Molecular Tags Governing Agronomic Traits

14.5 Genomics-Assisted Crop Improvement

15 Combinatorial Approaches Utilizing Nutraceuticals in Cancer Chemoprevention and Therapy

15.1 Introduction

15.2 Nutraceuticals

15.3 Nutraceuticals and Key Events in Cancer Development

15.4 Nutraceuticals in Combinatorial Therapy of Human Cancer: A Pledge of the Future

15.5 Curcumin: Potential for Combination Therapy

15.6 Resveratrol: Potential for Combination Therapy

15.7 Lycopene (a Carotenoid): Potential for Combinations Therapy

15.8 Soy Nutraceuticals: Potential for Combination Therapy

15.9 Tea Polyphenols Potential for Combinatorial Therapy

15.10 D-Limonene: Potential for Combination Therapy

15.11 Miscellaneous: Novel Nutraceuticals Formulation

15.12 Conclusion

16 Nutrigenomic Approaches to Understanding the Transcriptional and Metabolic Responses of Phytochemicals to Diet-Induced Obesity and its Complications

16.1 Introduction

16.2 Nutrigenomics

16.3 Obesity and Cardiometabolic Syndrome

16.4 Anti-Obesity Action of Luteolin

16.5 Conclusion

17 Going Beyond the Current Native Nutritional Food Through the Integration of the Omic Data in the Post-Genomic Era

17.1 Introduction

17.2 Starch and its Yield Improvement in Plants

17.3 An Extension of the (Resistant) Starch Yield Improvement Research on the Systems Biology Regime: Integration of the Omic Data from the Post-Genomic Technology

Part III: Proteomics

18 Proteomics and Nutrition Research

18.1 Introduction

18.2 Proteomics

18.3 Nutrition and Proteins

18.4 Nutritional Biomarkers

18.5 Nutritional Bioactives

18.6 Diet-Based Proteomics Application to Animal Products (Livestock Applications)

18.7 Proteomics and Food Safety

18.8 Conclusion

18.9 Significance

Conflict of Interests

19 Proteomics Analysis for the Functionality of Toona sinensis

19.1 Introduction

19.2 Toona sinensis

19.3 TSLs Regulate Functions of Testes/Spermatozoa

19.4 TSLs Regulate Liver Metabolism

19.5 TSL as a Novel Antioxidant

19.6 Possible Active Compounds in TSL Extracts

19.7 Conclusion

20 Proteomic Approaches to Identify Novel Therapeutics and Nutraceuticals from Filamentous Fungi: Prospects and Challenges

20.1 Introduction

20.2 Mushroom Derived Immunomodulators and their Target Cells in the Immune System

20.3 Mushroom Derived Metabolites in Treating Cancer

20.4 Mushroom Derived Metabolites in Infectious Diseases

20.5 Fungal Enzymes as Therapeutics and Dietary Supplements

20.6 Identification and Characterization of Mushroom Derived Bioactive Therapeutics

20.7 Challenges in Intracellular Proteome Preparation

20.8 Challenges in Extracellular Proteome Preparation

20.9 New Generation MS Technologies to Track the Dynamic Proteome

20.10 Glycoproteomics: A New Arsenal in the Proteomic Toolbox

20.11 Glycoproteomics of Filamentous Fungi.

20.12 High-Throughput Approaches to Decipher Fungal Glycan Structures

20.13 Challenges in MS Studies of Glycans/Glycopeptides

20.14 Optimized MS Instrumentation for Glycan Analysis

20.15 Tandem Mass Spectrometry

20.16 Bioinformatics for Glycoproteomics: Hitting Databases with MS Peaks

20.17 Predicting Glycan Structures with Computational Tools

20.18 Concluding Remarks: The Road Ahead

21 Proteomics and Metaproteomics for Studying Probiotic Activity

21.1 Introduction

21.2 Molecular Mechanisms of Probiotic Action as Studied by Proteomics

21.3 Probiotics and Prebiotics

21.4 Investigation on Human Microbiota Dynamics by Proteomics

21.5 Concluding Remarks and Future Directions

22 Proteomics Approach to Assess the Potency of Dietary Grape Seed Proanthocyanidins and Dimeric Procyanidin B2

22.1 Chemoprotective Properties of GSPs

22.2 Proteomic Platform

22.3 Proteomics Analysis of the Actions of GSPs

22.4 Functional Confirmation of Proteins

22.5 Future Perspectives

23 Genomic and Proteomic Approaches to Lung Transplantation: Identifying Relevant Biomarkers to Improve Surgical Outcome

23.1 Introduction

23.2 Lung Transplantation

23.3 Challenges of Lung Transplantation

23.4 Inflammatory Biomarkers with Lung Rejection: Markers of Inflammation Signaling such as CAMs, Chemokines, and Cytokines and their Status with Transplants

23.5 Microarray Technology to Identify Transplant Rejection Biomarkers

23.6 Challenges and Future Directions

24 Proteomics in Understanding the Molecular Basis of Phytochemicals for Health

24.1 Introduction

24.2 Proteomics in Phytochemical Research in Cancer Prevention

24.3 Perspectives

24.4 Proteomics in Phytochemical Research for Metabolic Diseases.

24.5 Proteomics for Neuroprotective Phytochemicals.

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters and index.

Description based on print version record.

ISBN:

9781118930434

1118930436

9781118930465

1118930460

9781118930458

1118930452

OCLC:

908699068