Microwaves in organic and medicinal chemistry / C. Oliver Kappe, Alexander Stadler and Doris Dallinger.

Format:

Book

Author/Creator:

Kappe, C. Oliver.

Contributor:

Dallinger, Doris.

Stadler, Alexander, 1973-

Series:

Methods and principles in medicinal chemistry ; v. 52.

Methods and principles in medicinal chemistry ; v. 52

Language:

English

Subjects (All):

Microwaves.

Organic compounds--Synthesis.

Organic compounds.

Pharmaceutical chemistry.

Physical Description:

1 online resource (686 p.)

Edition:

2nd ed.

Place of Publication:

Weinheim : Wiley-VCH, c2012.

Language Note:

English

Summary:

Tailored to the needs of medicinal and natural products chemists, the second edition of this unique handbook brings the contents up to speed, almost doubling the amount of chemical information with an additional volume. As in the predecessor, a short introductory section covers the theoretical background and evaluates currently available instrumentation and equipment. The main part of the book then goes on to systematically survey the complete range of published microwave-assisted synthesis methods from their beginnings in the 1990's to mid-2011, drawing on data from more than 5,000 reports

Contents:

Microwaves in Organic and Medicinal Chemistry; Contents; Preface; Personal Foreword to the First Edition; Personal Foreword to the Second Edition; 1 Introduction: Microwave Synthesis in Perspective; 1.1 Microwave Synthesis and Medicinal Chemistry; 1.2 Microwave-Assisted Organic Synthesis (MAOS): A Brief History; 1.3 Scope and Organization of the Book; References; 2 Microwave Theory; 2.1 Microwave Radiation; 2.2 Microwave Dielectric Heating; 2.3 Dielectric Properties; 2.4 Microwave versus Conventional Thermal Heating; 2.5 Microwave Effects; 2.5.1 Temperature Monitoring in Microwave Chemistry

2.5.2 Thermal Effects (Kinetics)2.5.3 Specific Microwave Effects; 2.5.4 Nonthermal (Athermal) Microwave Effects; References; 3 Equipment Review; 3.1 Introduction; 3.2 Domestic Microwave Ovens; 3.3 Dedicated Microwave Reactors for Organic Synthesis; 3.4 Single-Mode Instruments; 3.4.1 Anton Paar GmbH; 3.4.1.1 Monowave 300; 3.4.2 Biotage AB; 3.4.2.1 Initiator Platform; 3.4.2.2 Chemspeed SWAVE; 3.4.2.3 Peptide Synthesizers; 3.4.3 CEM Corporation; 3.4.3.1 Discover Platform; 3.4.3.2 Explorer Systems; 3.4.3.3 Voyager System; 3.4.3.4 Peptide Synthesizers; 3.5 Multimode Instruments

3.5.1 Anton Paar GmbH3.5.1.1 Synthos 3000; 3.5.1.2 Masterwave Benchtop Reactor; 3.5.2 Biotage AB; 3.5.3 CEM Corporation; 3.5.3.1 MARS Scale-Up System Accessories; 3.5.3.2 MARS Parallel System Accessories; 3.5.4 Milestone s.r.l; 3.5.4.1 MultiSYNTH System; 3.5.4.2 MicroSYNTH Labstation; 3.5.4.3 StartSYNTH; 3.5.4.4 Scale-Up Systems; 3.5.4.5 Microwave-Heated Autoclave Systems; References; 4 Microwave Processing Techniques; 4.1 Solvent-Free Reactions; 4.2 Phase-Transfer Catalysis; 4.3 Open- versus Closed-Vessel Conditions; 4.4 Pre-pressurized Reaction Vessels; 4.5 Nonclassical Solvents

4.5.1 Water as Solvent 4.5.2 Ionic Liquids; 4.6 Passive Heating Elements; 4.7 Processing Techniques in Drug Discovery and High-Throughput Synthesis; 4.7.1 Automated Sequential versus Parallel Processing; 4.7.2 High-Throughput Synthesis Methods; 4.7.2.1 Solid-Phase Synthesis; 4.7.2.2 Soluble Polymer-Supported Synthesis; 4.7.2.3 Fluorous-Phase Organic Synthesis; 4.7.2.4 Polymer-Supported Reagents, Catalysts, and Scavengers; 4.8 Scale-Up in Batch and Continuous Flow; 4.8.1 Scale-Up in Batch and Parallel; 4.8.2 Scale-Up Using Continuous Flow Techniques; 4.8.3 Scale-Up Using Stop-Flow Techniques

4.8.4 Microwave Reactor Systems for Production Scale References; 5 Literature Survey Part A: Transition Metal-Catalyzed Reactions; 5.1 General Comments; 5.2 Carbon-Carbon Bond Formations; 5.2.1 Heck Reactions; 5.2.2 Suzuki-Miyaura Reactions; 5.2.3 Sonogashira Reactions; 5.2.4 Stille Reactions; 5.2.5 Negishi, Kumada, and Related Reactions; 5.2.6 Carbonylation Reactions; 5.2.7 Asymmetric Allylic Alkylations; 5.2.8 Miscellaneous Carbon-Carbon Bond-Forming Reactions; 5.3 Carbon-Heteroatom Bond Formations; 5.3.1 Buchwald-Hartwig Reactions; 5.3.2 Ullmann Condensation Reactions

5.3.3 Miscellaneous Carbon-Heteroatom Bond-Forming Reactions

Notes:

Previous ed.: 2005.

Includes bibliographical references and index.

ISBN:

9786613640529

9783527647842

3527647848

9781280663598

1280663596

9783527647828

3527647821

9783527647859

3527647856

OCLC:

784885989